Structure−Activity Relationships of Dimethindene Derivatives as New M2-Selective Muscarinic Receptor Antagonists

Thomas M. Böhme; Christine Keim; Kai Kreutzmann; Matthias Linder; Theo Dingermann; Gerd Dannhardt; Ernst Mutschler; Günter Lambrecht

doi:10.1021/jm020895l

Structure−Activity Relationships of Dimethindene Derivatives as New M2-Selective Muscarinic Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm020895l ◽

2003 ◽

Vol 46 (5) ◽

pp. 856-867 ◽

Cited By ~ 23

Author(s):

Thomas M. Böhme ◽

Christine Keim ◽

Kai Kreutzmann ◽

Matthias Linder ◽

Theo Dingermann ◽

...

Keyword(s):

Muscarinic Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Muscarinic Receptor Antagonists

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Quantitative Structure—Activity Relationship (QSAR) Studies on Sulfide Analogues as Potent M2 Muscarinic Receptor Antagonists.

ChemInform ◽

10.1002/chin.200622145 ◽

2006 ◽

Vol 37 (22) ◽

Author(s):

A. K. Srivastava ◽

A. A. Khan ◽

Abha Tripathi ◽

Archana Archana

Keyword(s):

Muscarinic Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Qsar Studies ◽

Structure Activity ◽

Muscarinic Receptor Antagonists ◽

M2 Muscarinic Receptor

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Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(99)00101-8 ◽

1999 ◽

Vol 9 (6) ◽

pp. 901-906 ◽

Cited By ~ 46

Author(s):

Darío Doller ◽

Samuel Chackalamannil ◽

Michael Czarniecki ◽

Robert McQuade ◽

Vilma Ruperto

Keyword(s):

Muscarinic Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity ◽

Muscarinic Receptor Antagonists

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ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationship Studies of Himbacine Derived Muscarinic Receptor Antagonists.

ChemInform ◽

10.1002/chin.199927234 ◽

2010 ◽

Vol 30 (27) ◽

pp. no-no

Author(s):

Dario Doller ◽

Samuel Chackalamannil ◽

Michael Czarniecki ◽

Robert McQuade ◽

Vilma Ruperto

Keyword(s):

Muscarinic Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity ◽

Muscarinic Receptor Antagonists

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Synthesis, Molecular Pharmacology, and Structure–Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00442 ◽

2021 ◽

Author(s):

Harvey F. Fulo ◽

Amal Shoeib ◽

Christian V. Cabanlong ◽

Alexander H. Williams ◽

Chang-Guo Zhan ◽

...

Keyword(s):

Molecular Pharmacology ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure−Activity Relationships of 2-Substitutedd-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of thed-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm9600914 ◽

1996 ◽

Vol 39 (12) ◽

pp. 2313-2330 ◽

Cited By ~ 14

Author(s):

Takehiro Fukami ◽

Takeru Yamakawa ◽

Kenji Niiyama ◽

Hisaki Kojima ◽

Yuuka Amano ◽

...

Keyword(s):

Tryptophan Residue ◽

Receptor Subtype ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Subtype Selectivity ◽

Structure Activity ◽

Endothelin A

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Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)84014-7 ◽

1997 ◽

Vol 32 (6) ◽

pp. 515-522 ◽

Cited By ~ 8

Author(s):

P.C. Astles ◽

T.J. Brown ◽

N.V. Harris ◽

M.F. Harper ◽

C McCarthy ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Synthesis and structure–activity relationships of ( R )-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.02.004 ◽

2004 ◽

Vol 14 (9) ◽

pp. 2269-2274 ◽

Cited By ~ 14

Author(s):

Martin W Rowbottom ◽

Fabio C Tucci ◽

Yun-Fei Zhu ◽

Zhiqiang Guo ◽

Timothy D Gross ◽

...

Keyword(s):

Gnrh Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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In vitrofunctional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/1440-1681.12191 ◽

2014 ◽

Vol 41 (2) ◽

pp. 139-146 ◽

Cited By ~ 3

Author(s):

Uday K Killi ◽

Vladimir Wsol ◽

Ondrej Soukup ◽

Kamil Kuca ◽

Michael Winder ◽

...

Keyword(s):

Urinary Bladder ◽

Muscarinic Receptor ◽

Acetylcholine Esterase ◽

Receptor Antagonists ◽

Acetylcholine Esterase Inhibitors ◽

Esterase Inhibitors ◽

Muscarinic Receptor Antagonists

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00742-4 ◽

2002 ◽

Vol 12 (23) ◽

pp. 3479-3482 ◽

Cited By ~ 6

Author(s):

Craig D. Boyle ◽

Susan F. Vice ◽

Jennifer Campion ◽

Samuel Chackalamannil ◽

Claire M. Lankin ◽

...

Keyword(s):

Muscarinic Receptor ◽

Receptor Antagonists ◽

In Vivo Efficacy ◽

Muscarinic Receptor Antagonists ◽

M2 Muscarinic Receptor ◽

Pharmacokinetic Properties

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EEG dissociation induced by muscarinic receptor antagonists: Coherent 40 Hz oscillations in a background of slow waves and spindles

Behavioural Brain Research ◽

10.1016/j.bbr.2018.10.016 ◽

2019 ◽

Vol 359 ◽

pp. 28-37 ◽

Cited By ~ 3

Author(s):

Santiago Castro-Zaballa ◽

Matías Cavelli ◽

Joaquín González ◽

Jaime Monti ◽

Atilio Falconi ◽

...

Keyword(s):

Muscarinic Receptor ◽

Slow Waves ◽

Receptor Antagonists ◽

Muscarinic Receptor Antagonists ◽

40 Hz

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