KARAKTERISTIK DINAMIK COMPUTER NUMERICAL CONTROL MILLING ROUTER 4 AXIS

Penelitian ini dilakukan untuk mengetahui karakteristik dinamik Computer Numerical Control Router 4 Axis dengan menggunakan metode Bump Test. Pengujian dilakukan dengan cara menempatkan sensor Accelerometer Khoctek 107b pada Mesin CNC Router 4 Axis pada sumbu x, y, z dikerangka atas, kerangka bawah, dan spindle. Hasil eksperimen pengujian getaran Mesin CNC dibagi kedalam dua proses pengujian yaitu kondisi normal dan kondisi rusak pada masing-masing sumbu. Diperoleh bahwa pengujian ini menghasilkan frekuensi global dimana frekuensi 8 Hz, 24 Hz, dan 40 Hz muncul disetiap sumbu x, y, dan z pada kerangka atas, kerangka bawah dan spindle. Pada mesin dengan kondisi rusak muncul frekuensi lokal pada sumbu y kerangka atas sebesar 5 Hz. Kemudian pada sumbu y spindle muncul frekuensi lokal sebesar 10 Hz, 56 Hz, dan 88 Hz. Munculnya frekuensi lokal menandakan adanya kerusakan pada CNC oleh sumbu tertentu selain frekuensi global.

Source Level of Antarctic Blue and Fin Whale Sounds Recorded on Sonobuoys Deployed in the Deep-Ocean Off Antarctica

The source levels, SL, of Antarctic blue and fin whale calls were estimated using acoustic recordings collected from directional sonobuoys deployed during an Antarctic voyage in 2019. Antarctic blue whale call types included stereotyped song and downswept frequency-modulated calls, often, respectively, referred to as Z-calls (comprising song units-A, B, and C) and D-calls. Fin whale calls included 20 Hz pulses and 40 Hz downswept calls. Source levels were obtained by measuring received levels (RL) and modelling transmission losses (TL) for each detection. Estimates of SL were sensitive to the parameters used in TL models, particularly the seafloor geoacoustic properties and depth of the calling whale. For our best estimate of TL and whale-depth, mean SL in dB re 1 μPa ± 1 standard deviation ranged between 188–191 ± 6–8 dB for blue whale call types and 189–192 ± 6 dB for fin whale call types. These estimates of SL are the first from the Southern Hemisphere for D-calls and 40 Hz downsweeps, and the largest sample size to-date for Antarctic blue whale song. Knowledge of source levels is essential for estimating the detection range and communication space of these calls and will enable more accurate comparisons of detections of these sounds from sonobuoy surveys and across international long-term monitoring networks.

Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series

Background: Alzheimer’s disease (AD) is characterized by diffuse amyloid-β (Aβ) and phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced 40 Hz gamma oscillations have been showing to reduce Aβ and p-Tau deposition presumably via microglia activation in AD mouse models. Objective: We aimed to translate preclinical data on gamma-induction in AD patients by means of transcranial alternating current stimulation (tACS). Methods: Four participants with mild-to-moderate AD received 1 h of daily 40 Hz (gamma) tACS for 4 weeks (Monday to Friday) targeting the bitemporal lobes (20 h treatment duration). Participant underwent Aβ, p-Tau, and microglia PET imaging with [11C]-PiB, [18F]-FTP, and [11C]-PBR28 respectively, before and after the intervention along with electrophysiological assessment. Results: No adverse events were reported, and an increase in gamma spectral power on EEG was observed after the treatment. [18F]-FTP PET revealed a significant decrease over 2% of p-Tau burden in 3/4 patients following the tACS treatment, primarily involving the temporal lobe regions targeted by tACS and especially mesial regions (e.g., entorhinal cortex). The amount of intracerebral Aβ as measured by [11C]-PiB was not significantly influenced by tACS, whereas 1/4 reported a significant decrease of microglia activation as measured by [11C]-PBR28. Conclusion: tACS seems to represent a safe and feasible option for gamma induction in AD patients, with preliminary evidence of a possible effect on protein clearance partially mimicking what is observed in animal models. Longer interventions and placebo control conditions are needed to fully evaluate the potential for tACS to slow disease progression.

Features of time variations of microseismic noise at seismic stations in Tajikistan

The spectral structure of microseismic noise in the frequency range of 0.01-40 Hz at different times of the day and year, recorded by broadband equipment at eight IRIS group seismic stations in Tajikistan in 2005-2020, was analyzed. Two disjoint frequency ranges are distinguished, which we conditionally call "high-frequency" (2-40 Hz) and "low-frequency" (0.01-0.75 Hz) noise, separated by a natural drop in the noise amplitude to 20-30 Db. It is assumed that the high-frequency range of noise has a local nature, due to exogenous sources of natural origin in the form of wind gusts, concussions from powerful watercourses and fluctuations in the level of large reservoirs, as well as man-made in-terference due to road and quarry explosions, the work of large industrial enterprises and concussions from road traffic. Low-frequency noise is most likely caused by global storm microseisms. High-frequency noise has a well-defined daily frequency, which is completely absent in low-frequency noise. At the same time, in both frequency ranges, the existence of a clearly pronounced seasonal peri-odicity has been established, the amplitude of which reaches 6-7 Db for high-frequency noise and about half as much for low-frequency noise. However, at the same time, the seasonal frequency of high frequency and low-frequency noise turns out to be antiphase, which indicates in favor of the different genesis of these two components of microseismic noise. The amplitude of the diurnal periodicity in variations of the high-frequency noise level is maximal during the daytime, remaining approximately constant for 8-10 hours. At the same time, the decline in the noise amplitude in the evening lasts longer than the steeper morning growth. The time intervals of a sharp increase and decrease in the intensity of the discussed daily extreme are quite well correlated, respectively, with morning and evening twilight at different times of the year. This is reflected in the wider flat part of the maximum noise level in summer compared to winter and the differences in its level up to 6 Db in favor of summer time. This observation can be considered as a manifestation of the deep influence of the Sun on the oscillatory processes that generate high-frequency microseismic noise.

40-Hz Blue Light Changes Hippocampal Activation and Functional Connectivity Underlying Recognition Memory

Research on light modulation has typically examined the wavelength, intensity, and exposure time of light, and measured rhythm, sleep, and cognitive ability to evaluate the regulatory effects of light variables on physiological and cognitive functions. Although the frequency of light is one of the main dimensions of light, few studies have attempted to manipulate it to test the effect on brain activation and performance. Recently, 40-Hz light stimulation has been proven to significantly alleviate deficits in gamma oscillation of the hippocampus caused by Alzheimer’s disease. Although this oscillation is one of the key functional characteristics of performing memory tasks in healthy people, there is no evidence that 40-Hz blue light exposure can effectively regulate brain activities related to complex cognitive tasks. In the current study, we examined the difference in the effects of 40-Hz light or 0-Hz light exposure on brain activation and functional connectivity during a recognition memory task. Through joint augmentation of visual area activation, 40-Hz light enhanced brain areas mostly in the limbic system that are related to memory, such as the hippocampus and thalamus. Conversely, 0-Hz light enhanced brain areas mostly in the prefrontal cortex. Additionally, functional connection analysis, with the hippocampus as the seed point, showed that 40-Hz light enhanced connection with the superior parietal lobe and reduced the connection with the default network. These results indicate that light at a frequency of 40 Hz can change the activity and functional connection of memory-related core brain areas. They also indicate that in the use of light to regulate cognitive functions, its frequency characteristics merit attention.

40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases

Previous studies showed that entrainment of light flicker at low gamma frequencies provided neuroprotection in mouse models of Alzheimer’s disease (AD) and stroke. The current study was set to explore the feasibility of using 40 Hz light flicker for human brain stimulation for future development as a tool for brain disease treatment. The effect of 40 Hz low gamma frequency light on a cohort of healthy human brains was examined using 64 channel electroencephalography (EEG), followed by microstate analyses. A random frequency light flicker was used as a negative control treatment. Light flicker at 40 Hz significantly increased the corresponding band power in the O1, Oz, and O3 electrodes covering the occipital areas of both sides of the brain, indicating potent entrainment with 40 Hz light flicker in the visual cortex area. Importantly, the 40 Hz light flicker significantly altered microstate coverage, transition duration, and the Lempel-Ziv complexity (LZC) compared to the rest state. Microstate metrics are known to change in the brains of Alzheimer’s disease, schizophrenia, and stroke patients. The current study laid the foundation for the future development of 40 Hz light flicker as therapeutics for brain diseases.

Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβ plaques and brain rhythms in 5×FAD mice

Background Alzheimer’s disease (AD) is the most common cause of dementia, and is characterized by amyloid-β (Aβ) plaques and tauopathy. Reducing Aβ has been considered a major AD treatment strategy in pharmacological and non-pharmacological approaches. Impairment of gamma oscillations, which play an important role in perception and cognitive function, has been shown in mouse AD models and human patients. Recently, the therapeutic effect of gamma entrainment in AD mouse models has been reported. Given that ultrasound is an emerging neuromodulation modality, we investigated the effect of ultrasound stimulation pulsed at gamma frequency (40 Hz) in an AD mouse model. Methods We implanted electroencephalogram (EEG) electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice (n = 12 and 6, respectively). Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks, and the other six mice received sham treatment. Soluble and insoluble Aβ levels in the brain were measured by enzyme-linked immunosorbent assay. Spontaneous EEG gamma power was computed by wavelet analysis, and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude coupling. Results We found that the total Aβ42 levels, especially insoluble Aβ42, in the treatment group decreased in pre- and infra-limbic cortex (PIL) compared to that of the sham treatment group. A reduction in the number of Aβ plaques was also observed in the hippocampus. There was no increase in microbleeding in the transcranial ultrasound stimulation (tUS) group. In addition, the length and number of microglial processes decreased in PIL and hippocampus. Encelphalographic spontaneous gamma power was increased, and cross-frequency coupling was normalized, implying functional improvement after tUS stimulation. Conclusion These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by reducing the Aβ load and improving brain connectivity.

Snake, rattle ‘n’ run

Researchers have found that rattlesnakes use an aural trick to increase their rattling frequency from about 40 Hz to 60–100 Hz if an object approaches them.

Rhythmic auditory stimulation rescues cognitive flexibility in mutant mice with impaired gamma synchrony

Neural synchronization at gamma (~40 Hz) frequencies is believed to contribute to brain function and be deficient in disorders including Alzheimer's disease and schizophrenia. Gamma-frequency sensory stimulation has been proposed as a non-invasive treatment for deficient gamma synchrony and associated cognitive deficits, and has been shown to be effective in mouse models of Alzheimer's disease. However, both the mechanism and applicability of this approach remain unclear. Here we tested this approach using mutant (Dlx5/6+/-) mice which have deficits in gamma synchrony and the ability to learn to shift between rules which use different types of cues to indicate reward locations. 40 Hz auditory stimulation rescues rule shifting in Dlx5/6+/- mice. However, this improvement does not outlast the period of stimulation, and is not associated with normalized gamma synchrony, measured using genetically encoded voltage indicators. These results show how gamma-frequency sensory stimulation may improve behavior without fully restoring normal circuit function.

Is 20 Hz Whole-Body Vibration Training Better for Older Individuals than 40 Hz?

In recent years, whole-body vibration (WBV) training has been used as a training method in health promotion. This study attempted to use WBV at three different frequencies (20, 30, and 40 Hz) with subjects from different age groups to analyze the activation of the rectus femoris muscle. The subjects included 47 females and 51 males with an average age of 45.1 ± 15.2 years. Results indicated significant differences in subjects from different age groups at 20 Hz WBV. Muscle contraction was greater in the subjects who were older (F(4,93) = 82.448, p < 0.001). However, at 30 Hz WBV, the difference was not significant (F(4,93) = 2.373, p = 0.058). At 40 Hz WBV, muscle contraction was less in the older subjects than in the younger subjects (F(4,93) = 18.025, p < 0.001). The spectrum analysis also indicated that at 40 Hz there was less muscle activity during WBV in the older subjects than in the younger ones. Therefore, age was found to have a significant effect on muscle activation during WBV at different frequencies. If the training is offered to elderly subjects, their neuromuscular responses to 20 Hz WBV will be more suitable than to 40 Hz WBV.