Synthesis and Structure−Activity Relationships of 2-Substitutedd-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists:  Importance of the C-2 Substituent of thed-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

Takehiro Fukami; Takeru Yamakawa; Kenji Niiyama; Hisaki Kojima; Yuuka Amano; Fuyuko Kanda; Satoshi Ozaki; Takahiro Fukuroda; Masaki Ihara; Mitsuo Yano; Kiyofumi Ishikawa

doi:10.1021/jm9600914

Synthesis and Structure−Activity Relationships of 2-Substitutedd-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of thed-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm9600914 ◽

1996 ◽

Vol 39 (12) ◽

pp. 2313-2330 ◽

Cited By ~ 14

Author(s):

Takehiro Fukami ◽

Takeru Yamakawa ◽

Kenji Niiyama ◽

Hisaki Kojima ◽

Yuuka Amano ◽

...

Keyword(s):

Tryptophan Residue ◽

Receptor Subtype ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Subtype Selectivity ◽

Structure Activity ◽

Endothelin A

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Structure–Activity relationships of 2-substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids as a novel class of endothelin receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00663-7 ◽

2002 ◽

Vol 12 (21) ◽

pp. 3041-3045 ◽

Cited By ~ 7

Author(s):

Kenji Niiyama ◽

Hirobumi Takahashi ◽

Toshio Nagase ◽

Hisaki Kojima ◽

Yuka Amano ◽

...

Keyword(s):

Carboxylic Acids ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure-Activity Relationships in a Series of Ethenesulfonamide Derivatives, a Novel Class of Endothelin Receptor Antagonists.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.49.1593 ◽

2001 ◽

Vol 49 (12) ◽

pp. 1593-1603 ◽

Cited By ~ 7

Author(s):

Hironori HARADA ◽

Jun-ichi KAZAMI ◽

Susumu WATANUKI ◽

Ryuji TSUZUKI ◽

Katsumi SUDOH ◽

...

Keyword(s):

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Structure—Activity Relationships of 2-Substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic Acids as a Novel Class of Endothelin Receptor Antagonists.

ChemInform ◽

10.1002/chin.200309133 ◽

2003 ◽

Vol 34 (9) ◽

Author(s):

Kenji Niiyama ◽

et al. et al.

Keyword(s):

Carboxylic Acids ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Endothelin receptor antagonists: synthesis and structure–activity relationships of substituted benzothiazine-1,1-dioxides

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(98)00080-7 ◽

1998 ◽

Vol 6 (9) ◽

pp. 1447-1456 ◽

Cited By ~ 10

Author(s):

K.A. Berryman ◽

J.J. Edmunds ◽

A.M. Bunker ◽

S. Haleen ◽

J. Bryant ◽

...

Keyword(s):

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Synthesis and Structure-Activity Relationships in a Series of Ethenesulfonamide Derivatives, a Novel Class of Endothelin Receptor Antagonists.

ChemInform ◽

10.1002/chin.200217147 ◽

2010 ◽

Vol 33 (17) ◽

pp. no-no

Author(s):

Hironori Harada ◽

Jun-ichi Kazami ◽

Susumu Watanuki ◽

Ryuji Tsuzuki ◽

Katsumi Sudoh ◽

...

Keyword(s):

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)84014-7 ◽

1997 ◽

Vol 32 (6) ◽

pp. 515-522 ◽

Cited By ~ 8

Author(s):

P.C. Astles ◽

T.J. Brown ◽

N.V. Harris ◽

M.F. Harper ◽

C McCarthy ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Importance of Subtype Selectivity for Endothelin Receptor Antagonists in the Human Vasculature

Translational Vascular Medicine ◽

10.1007/978-0-85729-920-8_10 ◽

2011 ◽

pp. 151-172

Author(s):

Janet J. Maguire ◽

Anthony P. Davenport

Keyword(s):

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Subtype Selectivity

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Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ETAAntagonism

Journal of Medicinal Chemistry ◽

10.1021/jm010382z ◽

2002 ◽

Vol 45 (10) ◽

pp. 2041-2055 ◽

Cited By ~ 60

Author(s):

Natsuki Ishizuka ◽

Ken-ichi Matsumura ◽

Katsunori Sakai ◽

Masafumi Fujimoto ◽

Shin-ichi Mihara ◽

...

Keyword(s):

Carboxylic Acid ◽

Receptor Antagonist ◽

Basic Structure ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00551-3 ◽

1996 ◽

Vol 6 (24) ◽

pp. 2999-3002 ◽

Cited By ~ 14

Author(s):

X.-M. Cheng ◽

C. Lee ◽

S. Klutchko ◽

T. Winters ◽

E.E. Reynolds ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Selective Endothelin A Receptor Antagonists. 4. Discovery and Structure−Activity Relationships of Stilbene Acid and Alcohol Derivatives1-3

Journal of Medicinal Chemistry ◽

10.1021/jm970847e ◽

1998 ◽

Vol 41 (15) ◽

pp. 2745-2753 ◽

Cited By ~ 10

Author(s):

Peter C. Astles ◽

Thomas J. Brown ◽

Frank Halley ◽

Caroline M. Handscombe ◽

Neil V. Harris ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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