Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Antonello Mai; Gianluca Sbardella; Marino Artico; Rino Ragno; Silvio Massa; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Chiara Musiu; Massimiliano La Colla; Chiara Murgioni; Paolo La Colla; Roberta Loddo

doi:10.1021/jm010853h

Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Journal of Medicinal Chemistry ◽

10.1021/jm010853h ◽

2001 ◽

Vol 44 (16) ◽

pp. 2544-2554 ◽

Cited By ~ 57

Author(s):

Antonello Mai ◽

Gianluca Sbardella ◽

Marino Artico ◽

Rino Ragno ◽

Silvio Massa ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Design Synthesis ◽

Conformationally Restricted ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00144-9 ◽

2000 ◽

Vol 8 (9) ◽

pp. 2305-2309 ◽

Cited By ~ 12

Author(s):

Romano Silvestri ◽

Marino Artico ◽

Gabriella De Martino ◽

Ettore Novellino ◽

Giovanni Greco ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Computer Assisted ◽

Design Synthesis ◽

Computer Assisted Design ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

MedChemComm ◽

10.1039/c3md00247k ◽

2014 ◽

Vol 5 (4) ◽

pp. 468 ◽

Cited By ~ 4

Author(s):

Hai-Qiu Wu ◽

Christophe Pannecouque ◽

Zi-Hong Yan ◽

Wen-Xue Chen ◽

Qiu-Qin He ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Conformationally Restricted ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation

Il Farmaco ◽

10.1016/j.farmac.2005.03.005 ◽

2005 ◽

Vol 60 (5) ◽

pp. 377-384 ◽

Cited By ~ 27

Author(s):

D. Sriram ◽

T.R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

Journal of Medicinal Chemistry ◽

10.1021/jm201506e ◽

2012 ◽

Vol 55 (5) ◽

pp. 2242-2250 ◽

Cited By ~ 26

Author(s):

Xiaowei Wang ◽

Jianfang Zhang ◽

Yang Huang ◽

Ruiping Wang ◽

Liang Zhang ◽

...

Keyword(s):

Drug Resistance ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Resistance Profile ◽

Drug Resistance Profile ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer Aminopyrimidinimino Isatin Analogues as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors for HIV and Other Opportunistic Infections of AIDS: Design, Synthesis and Biological Evaluation.

ChemInform ◽

10.1002/chin.200539145 ◽

2005 ◽

Vol 36 (39) ◽

Author(s):

D. Sriram ◽

T. R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 Reverse Transcriptase

ChemMedChem ◽

10.1002/cmdc.201402015 ◽

2014 ◽

pp. n/a-n/a ◽

Cited By ~ 2

Author(s):

Rita Meleddu ◽

Valeria Cannas ◽

Simona Distinto ◽

Giorgia Sarais ◽

Claudia Del Vecchio ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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ChemInform Abstract: Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones (I): HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations.

ChemInform ◽

10.1002/chin.200030099 ◽

2010 ◽

Vol 31 (30) ◽

pp. no-no

Author(s):

Marino Artico ◽

et al. et al.

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Abstract Structure ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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