Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Hai-Qiu Wu; Christophe Pannecouque; Zi-Hong Yan; Wen-Xue Chen; Qiu-Qin He; Fen-Er Chen; Jan Balzarini; Dirk Daelemans; Erik De Clercq

doi:10.1039/c3md00247k

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

MedChemComm ◽

10.1039/c3md00247k ◽

2014 ◽

Vol 5 (4) ◽

pp. 468 ◽

Cited By ~ 4

Author(s):

Hai-Qiu Wu ◽

Christophe Pannecouque ◽

Zi-Hong Yan ◽

Wen-Xue Chen ◽

Qiu-Qin He ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Conformationally Restricted ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Journal of Medicinal Chemistry ◽

10.1021/jm010853h ◽

2001 ◽

Vol 44 (16) ◽

pp. 2544-2554 ◽

Cited By ~ 57

Author(s):

Antonello Mai ◽

Gianluca Sbardella ◽

Marino Artico ◽

Rino Ragno ◽

Silvio Massa ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Design Synthesis ◽

Conformationally Restricted ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00144-9 ◽

2000 ◽

Vol 8 (9) ◽

pp. 2305-2309 ◽

Cited By ~ 12

Author(s):

Romano Silvestri ◽

Marino Artico ◽

Gabriella De Martino ◽

Ettore Novellino ◽

Giovanni Greco ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Computer Assisted ◽

Design Synthesis ◽

Computer Assisted Design ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of DAPY–DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.11.032 ◽

2015 ◽

Vol 23 (3) ◽

pp. 624-631 ◽

Cited By ~ 7

Author(s):

Hai-Qiu Wu ◽

Jin Yao ◽

Qiu-Qin He ◽

Wen-Xue Chen ◽

Fen-Er Chen ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Nucleoside Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.02.039 ◽

2009 ◽

Vol 17 (7) ◽

pp. 2767-2774 ◽

Cited By ~ 23

Author(s):

Bailing Xu ◽

Yan Sun ◽

Ying Guo ◽

Yingli Cao ◽

Tao Yu

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Possess Increased Hydrolytic Stability

Journal of Medicinal Chemistry ◽

10.1021/jm070382k ◽

2007 ◽

Vol 50 (20) ◽

pp. 4854-4867 ◽

Cited By ~ 17

Author(s):

Matthew D. Cullen ◽

Bo-Liang Deng ◽

Tracy L. Hartman ◽

Karen M. Watson ◽

Robert W. Buckheit, ◽

...

Keyword(s):

Reverse Transcriptase ◽

Hydrolytic Stability ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.04.018 ◽

2016 ◽

Vol 24 (11) ◽

pp. 2519-2529 ◽

Cited By ~ 13

Author(s):

Birgit Viira ◽

Anastasia Selyutina ◽

Alfonso T. García-Sosa ◽

Maarit Karonen ◽

Jari Sinkkonen ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Triazine Derivatives ◽

Low Toxicity ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.07.028 ◽

2009 ◽

Vol 17 (16) ◽

pp. 5775-5781 ◽

Cited By ~ 35

Author(s):

Peng Zhan ◽

Xinyong Liu ◽

Junjie Zhu ◽

Zengjun Fang ◽

Zhenyu Li ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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