Design, Synthesis, and Biological Evaluation of 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 Reverse Transcriptase

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Rita Meleddu ◽  
Valeria Cannas ◽  
Simona Distinto ◽  
Giorgia Sarais ◽  
Claudia Del Vecchio ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Design, synthesis and biological evaluation of caffeoyl benzanilides as dual inhibitors of HIV integrase and CCR5

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 2028-2032 ◽  
Author(s):  
Xuefeng Sun ◽  
Ningning Fan ◽  
Weisi Xu ◽  
Yixing Sun ◽  
Xin Xie ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Hiv Integrase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Novel series of caffeoyl benzanilides have been synthesized and evaluated as dual inhibitors of HIV-1 CCR5/IN. Compound 9a exhibited the possibility of being a dual inhibitor of HIV-1.

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