Isothiourea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole with broad-spectrum anthelmintic activity

1987 ◽  
Vol 30 (10) ◽  
pp. 1848-1853 ◽  
Author(s):  
Malcolm D. Brewer ◽  
Roderick J. J. Dorgan ◽  
Brian R. Manger ◽  
Patrick Mamalis ◽  
Richard A. B. Webster
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity ◽  
Isothiourea Derivatives ◽  
Derivatives Of

ChemInform Abstract: Isothiourea Derivatives of 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole with Broad-Spectrum Anthelmintic Activity.

ChemInform ◽  
1988 ◽  
Vol 19 (10) ◽  
Author(s):  
M. D. BREWER ◽  
R. J. J. DORGAN ◽  
B. R. MANGER ◽  
P. MAMALIS ◽  
R. A. B. WEBSTER
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity ◽  
Isothiourea Derivatives ◽  
Derivatives Of

Multiple types of hydroxyl-rich cationic derivatives of PGMA for broad-spectrum antibacterial and antifouling coatings

2016 ◽  
Vol 7 (36) ◽  
pp. 5709-5718 ◽  
Author(s):  
Huimin Yuan ◽  
Bingran Yu ◽  
Li-Hai Fan ◽  
Meng Wang ◽  
Yiwen Zhu ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifouling Coatings ◽  
Derivatives Of

A series of hydroxyl-rich quaternized polymers with Ag ions have been proposed for broad-spectrum antibacterial and antifouling coatings.

Novel Broad-Spectrum Anthelmintics. Tetramisole1and Related Derivatives of 6-Arylimidazo[2,1-b]thiazole

1966 ◽  
Vol 9 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Alfons H. M. Raeymaekers ◽  
Fernand T. N. Allewijn ◽  
Jan Vandenberk ◽  
Paul J. A. Demoen ◽  
Theo T. T. Van Offenwert ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Derivatives Of

scholarly journals Overproduction of Wild-Type and Bioengineered Derivatives of the Lantibiotic Lacticin 3147

2006 ◽  
Vol 72 (6) ◽  
pp. 4492-4496 ◽  
Author(s):  
Paul D. Cotter ◽  
Lorraine A. Draper ◽  
Elaine M. Lawton ◽  
Olivia McAuliffe ◽  
Colin Hill ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Structural Genes ◽  
Wild Type ◽  
Genetic Determinants ◽  
Lacticin 3147 ◽  
Genes Encoding ◽  
High Level ◽  
Derivatives Of

ABSTRACT Lacticin 3147 is a broad-spectrum two-peptide lantibiotic whose genetic determinants are located on two divergent operons on the lactococcal plasmid pMRC01. Here we introduce each of 14 subclones, containing different combinations of lacticin 3147 genes, into MG1363 (pMRC01) and determine that a number of them can facilitate overproduction of the lantibiotic. Based on these studies it is apparent that while the provision of additional copies of genes encoding the biosynthetic/production machinery and the regulator LtnR is a requirement for high-level overproduction, the presence of additional copies of the structural genes (i.e., ltnA1A2) is not.

scholarly journals Influence of the type of salt-forming acids on the antiradiation activity of T1023 analogs – salts of N-isobutanoyl-S-isopropylisothiourea

2021 ◽  
Vol 14 (1) ◽  
pp. 68-74
Author(s):  
M. V. Filimonova ◽  
A. S. Saburova ◽  
L. I. Shevchenko ◽  
V. M. Makarchuk ◽  
A. A. Lychagin ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Initial Compound ◽  
Radioprotective Activity ◽  
Nos Inhibitors ◽  
Isothiourea Derivatives ◽  
Antiradiation Activity ◽  
Nos Inhibitor ◽  
New Compounds ◽  
Further Development ◽  
Derivatives Of

According to leading experts, the vast arsenal of radioprotective agents available in the world today does not fully meet modern practical needs, both in the field of radiation protection, and in the prevention and treatment of complications of radiotherapy. The purpose of the study was to evaluate the effect of the salt-forming acids type on the radioprotective activity of NOS inhibitor T1023. The chemical part of this study included methods of chemical synthesis, physicochemical and elemental analysis. Pharmacological part – assessment of acute toxicity using V.B. Prozorovsky express method and the study of radioprotective activity using Till and McCulloch method based on the ability of mice hematopoietic cells to form spleen colonies after irradiation. The number of endogenous hematopoietic spleen colonies were assessed on the 8th day after total exposure to gamma-irradiation at a dose of 6 Gy in six independent experiments. As a result of directed chemical synthesis, six new derivatives of T1023 – salts of N-isobutanoyl-S-isopropylisothiourea have been developed, identified and characterized. The results of studying the safety and radioprotective activity of the synthesized compounds showed that changes in the salt-forming acid don’t significantly influence the toxicity: all studied compounds are in the 3rd class of toxicity and hazard. At the same time, it was found that the replacement of the salt-forming acid significantly influenced the severity of the radioprotective effect. For some of these compounds radioprotective efficacy is comparable to or exceeds the efficacy of the initial compound T1023. It is important to note that these new compounds were used in lower, more save doses than T1023. The results suggest promising further development of NOS inhibitors – isothiourea derivatives as radioprotective agents.

Thiocyanate and Isothiourea Derivatives of Barbituric Acid

1952 ◽  
Vol 74 (2) ◽  
pp. 498-499 ◽  
Author(s):  
Glenn S. Skinner ◽  
William H. Waitz
Keyword(s):  
Barbituric Acid ◽  
Isothiourea Derivatives ◽  
Derivatives Of

Tissue distribution of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rats by a RP-HPLC method with fluorescence detection/UV detection

2015 ◽  
Vol 7 (18) ◽  
pp. 7690-7696 ◽  
Author(s):  
Changmin Shao ◽  
Jian Zheng ◽  
Bo Fan ◽  
Shaman Luo ◽  
Jixiang Lin ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tissue Distribution ◽  
Fluorescence Detection ◽  
Broad Spectrum ◽  
Hplc Method ◽  
Uv Detection ◽  
Camptotheca Acuminata ◽  
Rp Hplc ◽  
Derivatives Of

Both 10-methoxycamptothecin (MCPT) and 10-hydroxycamptothecin (HCPT) are natural derivatives of camptothecin (CPT) isolated from Camptotheca acuminata, possessing broad-spectrum antitumor activity.

Broad-spectrum intestinal anthelmintic activity of dithiazanine

1961 ◽  
Vol 6 (11) ◽  
pp. 1061-1068
Author(s):  
J. C. Swartzwelder ◽  
W. W. Frye ◽  
A. Pena Chavarria ◽  
R. Lampert ◽  
J. P. Muhleisen ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity
Sign in / Sign up

Export Citation Format

Share Document