Broad-spectrum intestinal anthelmintic activity of dithiazanine

1961 ◽  
Vol 6 (11) ◽  
pp. 1061-1068
Author(s):  
J. C. Swartzwelder ◽  
W. W. Frye ◽  
A. Pena Chavarria ◽  
R. Lampert ◽  
J. P. Muhleisen ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity

Isothiourea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole with broad-spectrum anthelmintic activity

1987 ◽  
Vol 30 (10) ◽  
pp. 1848-1853 ◽  
Author(s):  
Malcolm D. Brewer ◽  
Roderick J. J. Dorgan ◽  
Brian R. Manger ◽  
Patrick Mamalis ◽  
Richard A. B. Webster
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity ◽  
Isothiourea Derivatives ◽  
Derivatives Of

ChemInform Abstract: Isothiourea Derivatives of 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole with Broad-Spectrum Anthelmintic Activity.

ChemInform ◽  
1988 ◽  
Vol 19 (10) ◽  
Author(s):  
M. D. BREWER ◽  
R. J. J. DORGAN ◽  
B. R. MANGER ◽  
P. MAMALIS ◽  
R. A. B. WEBSTER
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity ◽  
Isothiourea Derivatives ◽  
Derivatives Of

Phytochemical Screening, Antibacterial, antifungal, and anthelmintic activity against plant pathogens of two Algerian plants: Pergularia tomentosa L. and Forsskaolea tenacissima L. from Oued Mzab (Northern Algerian Sahara)

2021 ◽  
Vol 18 ◽  
Author(s):  
Abdallah Aissa ◽  
Sujogya Kumar Panda ◽  
Haibo hu ◽  
Abdelkrim Kameli ◽  
Walter Luyten
Keyword(s):  
Antimicrobial Activity ◽  
Plant Extracts ◽  
Broad Spectrum ◽  
Plant Pathogens ◽  
Anthelmintic Activity ◽  
Diffusion Method ◽  
Good Activity ◽  
Phytochemical Screening ◽  
C Elegans ◽  
Starting Point

Background: Plants are an abundant natural source of potential chemical compounds; they have been widely used in various industries, such as pharmaceuticals, cosmetics and food. This work aims to study two Saharan medicinal plants by evaluating the activity of plant extract against bacterial and fungal plant pathogens as well as against the model nematode Caenorhabditis (C.) elegans. Methods: The antimicrobial activity of plant extracts against plants pathogen is assessed in a 96-well plate assay by calculating the percentage of inhibition of bacteria. The antifungal activity against plant pathogenic fungi was evaluated by the agar diffusion method, inhibition was calculated by measuring the diameter of the inhibition zone. Anthelmintic activity was evaluated by calculating the average movement of C. elegans worms. Preliminary Phytochemical Screening is realized with HPTLC. Results: Hexane and ethyl acetate extract of Pergularia tomentosa showed broad-spectrum antimicrobial activity; this plant has the potential to act as a broad-spectrum antibacterial biopesticide. Hexane extract of Forsskaolea tenacissima exhibited good activity against one fungus. The extracts of Pergularia tomentosa showed good activity against Caenorhabditis elegans, the extracts of Forsskaolea tenacissima exhibited a low activity. Preliminary phytochemical screening with HPTLC shows that both plants are rich in steroids and flavonoids. Conclusion: Our study shows that the studied plants may possess a broad-spectrum antibacterial effect with a narrow-spectrum antifungal properties which can offer a more sustainable crop protection with a much safer environmental and human health impact. Plant extracts that inhibited C. elegans could provide a starting point for the development of new anthelmintic drugs.

Evaluation of broad-spectrum anthelmintic activity in a novel assay against Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis in the gerbil Meriones unguiculatus

2006 ◽  
Vol 80 (4) ◽  
pp. 393-396 ◽  
Author(s):  
D.A. Ostlind ◽  
S. Cifelli ◽  
W.G. Mickle ◽  
S.K. Smith ◽  
D.V. Ewanciw ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Natural Product ◽  
Broad Spectrum ◽  
Haemonchus Contortus ◽  
Macrocyclic Lactone ◽  
Anthelmintic Activity ◽  
Meriones Unguiculatus ◽  
Trichostrongylus Colubriformis ◽  
Separate Part ◽  
Laboratory Assay

AbstractThe gerbil Meriones unguiculatus, infected with three species of nematodes, each located in a separate part of the gastrointestinal tract, provided a reliable laboratory assay for the evaluation of broad-spectrum anthelmintic activity. Gerbils harbouring 6-day-old infections of Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis were given selected broad-spectrum anthelmintics by gavage. Three benzimidazoles, thiabendazole, oxfendazole and albendazole, a tetrahydropyrimidine, morantel, an imidazothiazole, levamisole hydrochloride, a macrocyclic lactone, ivermectin and an experimental natural product, paraherquamide, were active against all three nematodes at various dosages. Trichostrongylus colubriformis was most sensitive to levamisole hydrochloride, morantel, thiabendazole and paraherquamide whereas ivermectin, oxfendazole and albendazole were more effective against H. contortus. All compounds were active against the caecal nematode T. sigmodontis although it was less sensitive than T. colubriformis. Haemonchus contortus was more sensitive than T. sigmodontis to all anthelmintics tested except thiabendazole.

A Strengths-Based Approach to Autism: Neurodiversity and Partnering With the Autism Community

2017 ◽  
Vol 2 (1) ◽  
pp. 56-68 ◽  
Author(s):  
Amy L. Donaldson ◽  
Karen Krejcha ◽  
Andy McMillin
Keyword(s):  
Broad Spectrum ◽  
First Language ◽  
Family Members ◽  
Community Identity ◽  
Speech Language Pathologists

The autism community represents a broad spectrum of individuals, including those experiencing autism, their parents and/or caregivers, friends and family members, professionals serving these individuals, and other allies and advocates. Beliefs, experiences, and values across the community can be quite varied. As such, it is important for the professionals serving the autism community to be well-informed about current discussions occurring within the community related to neurodiversity, a strengths-based approach to partnering with autism community, identity-first language, and concepts such as presumed competence. Given the frequency with which speech-language pathologists (SLPs) serve the autism community, the aim of this article is to introduce and briefly discuss these topics.

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