Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond

1987 ◽  
Vol 30 (10) ◽  
pp. 1729-1737 ◽  
Author(s):  
Giorgio Bolis ◽  
Anthony K. L. Fung ◽  
Jonathan Greer ◽  
Hollis D. Kleinert ◽  
Patrick A. Marcotte ◽  
...  
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Scissile Bond

Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

1989 ◽  
Vol 32 (7) ◽  
pp. 1652-1661 ◽  
Author(s):  
Mark C. Allen ◽  
Walter Fuhrer ◽  
Brian Tuck ◽  
Roy Wade ◽  
Jeanette M. Wood
Keyword(s):  
Transition State ◽  
Phosphorus Acid ◽  
Transition State Analog ◽  
Renin Inhibitors ◽  
Scissile Bond

Renin inhibitors. Dipeptide analogs of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency

1988 ◽  
Vol 31 (12) ◽  
pp. 2264-2276 ◽  
Author(s):  
Jay R. Luly ◽  
Nwe BaMaung ◽  
Jeff Soderquist ◽  
Anthony K. L. Fung ◽  
Herman Stein ◽  
...  
Keyword(s):  
Transition State ◽  
Inhibitory Potency ◽  
Renin Inhibitors ◽  
Scissile Bond

scholarly journals Synthesis and structure-activity relationships of human renin inhibitors designed from angiotensinogen transition state.

1990 ◽  
Vol 38 (9) ◽  
pp. 2487-2493 ◽  
Author(s):  
Kinji IIZUKA ◽  
Tetsuhide KAMIJO ◽  
Hiromu HARADA ◽  
Kenji AKAHANE ◽  
Tetsuhiro KUBOTA ◽  
...  
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Human Renin

Renin inhibitors based on novel dipeptide analogs. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond

1987 ◽  
Vol 30 (11) ◽  
pp. 1978-1983 ◽  
Author(s):  
Dale J. Kempf ◽  
Ed De Lara ◽  
Herman H. Stein ◽  
Jerome Cohen ◽  
Jacob J. Plattner
Keyword(s):  
Renin Inhibitors ◽  
Scissile Bond

ChemInform Abstract: Renin Inhibitors. Fluorine-Containing Transition-State Analogue Inserts

ChemInform ◽  
2010 ◽  
Vol 22 (38) ◽  
pp. no-no
Author(s):  
S. THAISRIVONGS ◽  
D. T. PALS ◽  
S. R. TURNER
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Transition State Analogue

Renin inhibitors. Design of angiotensinogen transition-state analogs containing novel (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid

1987 ◽  
Vol 30 (6) ◽  
pp. 976-982 ◽  
Author(s):  
Suvit Thaisrivongs ◽  
Donald T. Pals ◽  
Lisa T. Kroll ◽  
Steve R. Turner ◽  
Fu Son Han
Keyword(s):  
Transition State ◽  
Renin Inhibitors ◽  
Transition State Analogs
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