Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

Graham J. Atwell; Bruce F. Cain; Bruce C. Baguley; Graeme J. Finlay; William A. Denny

doi:10.1021/jm00377a017

Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

Journal of Medicinal Chemistry ◽

10.1021/jm00377a017 ◽

1984 ◽

Vol 27 (11) ◽

pp. 1481-1485 ◽

Cited By ~ 74

Author(s):

Graham J. Atwell ◽

Bruce F. Cain ◽

Bruce C. Baguley ◽

Graeme J. Finlay ◽

William A. Denny

Keyword(s):

Biological Activity ◽

Antitumor Agents ◽

Antitumor Agent ◽

New Class ◽

Potential Antitumor

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ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. PART 43. SYNTHESIS AND BIOLOGICAL ACTIVITY OF DIBASIC 9-AMINOACRIDINE-4-CARBOXAMIDES, A NEW CLASS OF ANTITUMOR AGENT

Chemischer Informationsdienst ◽

10.1002/chin.198512225 ◽

1985 ◽

Vol 16 (12) ◽

Author(s):

G. J. ATWELL ◽

B. F. CAIN ◽

B. C. BAGULEY ◽

G. J. FINLAY ◽

W. A. DENNY

Keyword(s):

Biological Activity ◽

Antitumor Agents ◽

Antitumor Agent ◽

New Class ◽

Potential Antitumor

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ChemInform Abstract: Potential Antitumor Agents. Part 45. Synthesis, DNA-Bindung Interaction and Biological Activity of Triacridine Derivatives.

Chemischer Informationsdienst ◽

10.1002/chin.198620209 ◽

1986 ◽

Vol 17 (20) ◽

Author(s):

G. J. ATWELL ◽

B. C. BAGULEY ◽

D. WILMANSKA ◽

W. A. DENNY

Keyword(s):

Biological Activity ◽

Antitumor Agents ◽

Potential Antitumor

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ChemInform Abstract: Potential Antitumor Agents. Part 44. Synthesis and Antitumor Activity of New Classes of Diacridines: Importance of Linker Chain Rigidity for DNA Binding Kinetics and Biological Activity.

Chemischer Informationsdienst ◽

10.1002/chin.198609180 ◽

1986 ◽

Vol 17 (9) ◽

Author(s):

W. A. DENNY ◽

G. J. ATWELL ◽

B. C. BAGULEY ◽

L. P. G. WAKELIN

Keyword(s):

Biological Activity ◽

Dna Binding ◽

Antitumor Activity ◽

Antitumor Agents ◽

Binding Kinetics ◽

Chain Rigidity ◽

Linker Chain ◽

Potential Antitumor

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Potential antitumor agents. 55. 6-Phenylphenanthridine-4-carboxamides: a new class of DNA-intercalating antitumor agents

Journal of Medicinal Chemistry ◽

10.1021/jm00399a015 ◽

1988 ◽

Vol 31 (4) ◽

pp. 774-779 ◽

Cited By ~ 46

Author(s):

Graham J. Atwell ◽

Bruce C. Baguley ◽

William A. Denny

Keyword(s):

Antitumor Agents ◽

New Class ◽

Potential Antitumor

Download Full-text

Synthesis and Biological Activity of Anthrapyrazoles Derivatives as Potential Antitumor Agents

Medicinal Chemistry ◽

10.2174/1573406410666140428152227 ◽

2014 ◽

Vol 10 (8) ◽

pp. 772-777

Author(s):

Jianhong Wang ◽

Huijun Zhao ◽

Zhaoyang Luo ◽

Zhaoyi Wang ◽

Yahong Zhang ◽

...

Keyword(s):

Biological Activity ◽

Antitumor Agents ◽

Potential Antitumor

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ChemInform Abstract: NUCLEOSIDE CONJUGATES AS POTENTIAL ANTITUMOR AGENTS. 2. SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-β-D-ARABINOFURANOSYLCYTOSINE CONJUGATES OF PREDNISOLONE AND PREDNISONE

Chemischer Informationsdienst ◽

10.1002/chin.198012362 ◽

1980 ◽

Vol 11 (12) ◽

Author(s):

C. I. HONG ◽

A. NECHAEV ◽

C. R. WEST

Keyword(s):

Biological Activity ◽

Antitumor Agents ◽

Potential Antitumor

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Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity

Journal of Medicinal Chemistry ◽

10.1021/jm00149a005 ◽

1985 ◽

Vol 28 (11) ◽

pp. 1568-1574 ◽

Cited By ~ 75

Author(s):

William A. Denny ◽

Graham J. Atwell ◽

Bruce C. Baguley ◽

Laurence P. G. Wakelin

Keyword(s):

Biological Activity ◽

Dna Binding ◽

Antitumor Activity ◽

Antitumor Agents ◽

Binding Kinetics ◽

Chain Rigidity ◽

Linker Chain ◽

Potential Antitumor

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Rational Design, Synthesis and Biological Evaluation of 3H-Naphtho[1,2,3-de]quinoline-2,7-diones: A New Class of Potential Antitumor Agents.

ChemInform ◽

10.1002/chin.200451116 ◽

2004 ◽

Vol 35 (51) ◽

Author(s):

I. Antonini ◽

P. Polucci ◽

A. Magnano ◽

S. Sparapani ◽

S. Martinelli

Keyword(s):

Rational Design ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

New Class ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

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Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of minimal DNA-intercalating agents which may not act via topoisomerase II

Journal of Medicinal Chemistry ◽

10.1021/jm00164a054 ◽

1990 ◽

Vol 33 (2) ◽

pp. 814-819 ◽

Cited By ~ 229

Author(s):

William A. Denny ◽

Gordon W. Rewcastle ◽

Bruce C. Baguley

Keyword(s):

Topoisomerase Ii ◽

Antitumor Agents ◽

Structure Activity Relationships ◽

New Class ◽

Structure Activity ◽

Intercalating Agents ◽

Potential Antitumor

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Potential antitumor agents. 45. Synthesis, DNA-binding interaction, and biological activity of triacridine derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00151a011 ◽

1986 ◽

Vol 29 (1) ◽

pp. 69-74 ◽

Cited By ~ 20

Author(s):

Graham J. Atwell ◽

Bruce C. Baguley ◽

Dorota Wilmanska ◽

William A. Denny

Keyword(s):

Biological Activity ◽

Dna Binding ◽

Antitumor Agents ◽

Binding Interaction ◽

Potential Antitumor

Download Full-text