Potential antitumor agents. 55. 6-Phenylphenanthridine-4-carboxamides: a new class of DNA-intercalating antitumor agents

1988 ◽  
Vol 31 (4) ◽  
pp. 774-779 ◽  
Author(s):  
Graham J. Atwell ◽  
Bruce C. Baguley ◽  
William A. Denny
Keyword(s):  
Antitumor Agents ◽  
New Class ◽  
Potential Antitumor

Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

1984 ◽  
Vol 27 (11) ◽  
pp. 1481-1485 ◽  
Author(s):  
Graham J. Atwell ◽  
Bruce F. Cain ◽  
Bruce C. Baguley ◽  
Graeme J. Finlay ◽  
William A. Denny
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Antitumor Agent ◽  
New Class ◽  
Potential Antitumor

Design, synthesis and biological evaluation of C(6)-indole celastrol derivatives as potential antitumor agents

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19620-19623 ◽  
Author(s):  
Kaiyong Tang ◽  
Jinwen Huang ◽  
Junfang Pan ◽  
Xuan Zhang ◽  
Wei Lu
Keyword(s):  
Cancer Cells ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
New Class ◽  
Synthesis And Biological Evaluation ◽  
Antiproliferative Activities ◽  
Potential Antitumor

A new class of C(6)-indole substituted celastrol derivatives were designed and synthesized. Among all these synthesized molecules, compound 4f and 4h displayed excellent in vitro antiproliferative activities against Bel7402 cancer cells.

Thiopyridyl triazine derivatives and their platinum complexes: A new class of potential antitumor agents

1994 ◽  
Vol 227 (1) ◽  
pp. 175-179 ◽  
Author(s):  
Soma Ray ◽  
Frank R. Smith ◽  
John N. Bridson ◽  
Quain Hong ◽  
Vernon J. Richardson ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Platinum Complexes ◽  
New Class ◽  
Triazine Derivatives ◽  
Potential Antitumor

scholarly journals Rhenium(I) Complexes with Pincer Ligands as a New Class of Potential Antitumor Agents

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 43
Author(s):  
Diana V. Aleksanyan ◽  
Svetlana G. Churusova ◽  
Ekaterina Yu. Rybalkina ◽  
Vladimir A. Kozlov
Keyword(s):  
Metal Complexes ◽  
Antitumor Agents ◽  
Solid Phase ◽  
Organometallic Compounds ◽  
Chemotherapeutic Agents ◽  
Palladium Complexes ◽  
Pincer Ligands ◽  
New Class ◽  
Solvent Free Conditions ◽  
Potential Antitumor

Transition metal complexes attract continuous research interest as potential antitumor agents. The most popular compounds are ruthenium, gold, titanium, osmium, iridium, zinc, and palladium complexes, which have already displayed cytotoxic features that are not typical for classical platinum-containing chemotherapeutic agents. Substantially lower attention is drawn to organometallic compounds of rhenium. However, the known examples of cytotoxic organometallic rhenium derivatives with bidentate heterocyclic, organophosphorus, labile alkoxide, and hydroxide ligands render further studies in this field very promising. As for their analogs with multidentate ligands, a literature survey has revealed only a few examples of cytotoxic rhenium complexes, whereas the antitumor activity of cyclometallated derivatives has not been studied at all. At the same time, it is known that the use of pincer-type ligands having specific tridentate monoanionic frameworks, which offer multiple options for directed structural modifications, allows one to finely tune the thermodynamic and kinetic stability of the resulting metal complexes. Therefore, we synthesized and studied the cytotoxic properties of a series of rhenium(I) complexes with tridentate pincer-type ligands based on functionalized carboxamides bearing ancillary donor groups both in the acid and amine components. It was shown that the target complexes can be obtained not only by the conventional solution-based method, but also under solvent-free conditions according to the solid-phase methodology recently developed in our group. The results obtained were used to define the main structure–activity relationships for a principally new class of potential antitumor agents and to choose the most promising compounds for further studies in order to create new pharmaceuticals.

Synthesis and antiproliferative activity of Benzocyclobutacarbazol derivatives. A new class of potential antitumor agents

2000 ◽  
Vol 10 (23) ◽  
pp. 2589-2591 ◽  
Author(s):  
S Graf-Christophe ◽  
C Kuehm-Caubère ◽  
P Renard ◽  
B Pfeiffer ◽  
A Pierré ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Antitumor Agents ◽  
New Class ◽  
Potential Antitumor
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