Irreversible enzyme inhibitors. CLXX. Inhibition of FUDR [5-fluoro-2'-deoxyuridine] phosphorylase from Walker 256 rat tumor by 1-substituted uracils

1970 ◽  
Vol 13 (3) ◽  
pp. 458-461 ◽  
Author(s):  
Bernard Randall Baker ◽  
James L. Kelley
Keyword(s):  
Enzyme Inhibitors ◽  
Walker 256 ◽  
Substituted Uracils ◽  
Rat Tumor

STUDIES ON THE TRANSPLANTATION OF A RAT TUMOR TO MICE

1957 ◽  
Vol 35 (1) ◽  
pp. 923-928
Author(s):  
A. Cameron Wallace ◽  
Susan Davis
Keyword(s):  
Tissue Culture ◽  
Mouse Brain ◽  
Serial Passage ◽  
Selective Adaptation ◽  
Growth And Survival ◽  
Heterologous Transplantation ◽  
Walker 256 ◽  
Foreign Species ◽  
Rat Tumor

The growth and survival of Walker 256 rat tumor grafted direct from rat into mouse thigh was compared with that of the same tumor after long continued residence in mouse brain, and also with that of tumors cultivated for a prolonged period in vitro. It was found that the pattern of growth and regression with tumor grown for 8 months in tissue culture was identical with that produced with tumor direct from rats. Tumor previously grown for 30 generations in mouse brain showed poorer growth and earlier regression. Since both prolonged growth in vitro and serial passage in mouse brain should have removed all the original rat stroma, it is concluded that loss of foreign stroma does not appreciably affect heterologous transplantation. Similarly, prolonged growth of this tumor in a foreign species under the conditions outlined apparently fails to produce any selective adaptation of the tumor to the host.

Response of intramuscular walker 256 rat tumor to sustained-release cyclophosphamide and ara-c capsules

1978 ◽  
Vol 10 (2) ◽  
pp. 133-140 ◽  
Author(s):  
J. C. Fu ◽  
D. L. Moyer ◽  
J. Cuevas ◽  
L. Cummings ◽  
A. Eaton ◽  
...  
Keyword(s):  
Sustained Release ◽  
Walker 256 ◽  
Rat Tumor

STUDIES ON THE TRANSPLANTATION OF A RAT TUMOR TO MICE

1957 ◽  
Vol 35 (11) ◽  
pp. 923-928
Author(s):  
A. Cameron Wallace ◽  
Susan Davis
Keyword(s):  
Tissue Culture ◽  
Mouse Brain ◽  
Serial Passage ◽  
Selective Adaptation ◽  
Growth And Survival ◽  
Heterologous Transplantation ◽  
Walker 256 ◽  
Foreign Species ◽  
Rat Tumor

The growth and survival of Walker 256 rat tumor grafted direct from rat into mouse thigh was compared with that of the same tumor after long continued residence in mouse brain, and also with that of tumors cultivated for a prolonged period in vitro. It was found that the pattern of growth and regression with tumor grown for 8 months in tissue culture was identical with that produced with tumor direct from rats. Tumor previously grown for 30 generations in mouse brain showed poorer growth and earlier regression. Since both prolonged growth in vitro and serial passage in mouse brain should have removed all the original rat stroma, it is concluded that loss of foreign stroma does not appreciably affect heterologous transplantation. Similarly, prolonged growth of this tumor in a foreign species under the conditions outlined apparently fails to produce any selective adaptation of the tumor to the host.

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