Irreversible Enzyme Inhibitors. LXXVII.1,2Inhibitors of Thymidine Phosphorylase. III.2Hydrophobic Bonding by 1-Substituted Uracils Containing Additional Substituents at the 5 and 6 Positions

B. R. Baker; Mitsutaka. Kawazu; Daniel V. Santi; Thomas J. Schwan

doi:10.1021/jm00315a003

Irreversible Enzyme Inhibitors. LXXVII.1,2Inhibitors of Thymidine Phosphorylase. III.2Hydrophobic Bonding by 1-Substituted Uracils Containing Additional Substituents at the 5 and 6 Positions

Journal of Medicinal Chemistry ◽

10.1021/jm00315a003 ◽

1967 ◽

Vol 10 (3) ◽

pp. 304-311 ◽

Cited By ~ 20

Author(s):

B. R. Baker ◽

Mitsutaka. Kawazu ◽

Daniel V. Santi ◽

Thomas J. Schwan

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Substituted Uracils

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Irreversible Enzyme Inhibitors. CIV. Inhibitors of Thymidine Phosphorylase. VIII. Further Studies on Hydrophobic Bonding with 6-Substituted Uracils

Journal of Medicinal Chemistry ◽

10.1021/jm00318a028 ◽

1967 ◽

Vol 10 (6) ◽

pp. 1109-1113 ◽

Cited By ~ 12

Author(s):

B. R. Baker ◽

Waclaw. Rzeszotarski

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Substituted Uracils ◽

Hydrophobic Bonding

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Irreversible Enzyme Inhibitors. LXXVI.1,2Inhibitors of Thymidine Phosphorylase. II.2Hydrophobic Bonding by 1-Substituted Uracils

Journal of Medicinal Chemistry ◽

10.1021/jm00315a002 ◽

1967 ◽

Vol 10 (3) ◽

pp. 302-304 ◽

Cited By ~ 8

Author(s):

B. R. Baker ◽

Mitsutaka. Kawazu

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Substituted Uracils

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Irreversible enzyme inhibitors 100 Inhibitors of thymidine phosphorylase 8. 6-(p-bromoacetamido-benzyl)uracil, an active-site-directed irreversible inhibitor

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600560907 ◽

1967 ◽

Vol 56 (9) ◽

pp. 1086-1092 ◽

Cited By ~ 4

Author(s):

B.R. Baker ◽

Mitsutaka Kawazu

Keyword(s):

Active Site ◽

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CLXXI. Inhibition of FUDR [5-fluoro-2'-deoxyuridine] phosphorylase from Walker 256 rat tumor by 5-substituted uracils

Journal of Medicinal Chemistry ◽

10.1021/jm00297a029 ◽

1970 ◽

Vol 13 (3) ◽

pp. 461-467 ◽

Cited By ~ 29

Author(s):

Bernard Randall Baker ◽

James L. Kelley

Keyword(s):

Enzyme Inhibitors ◽

Walker 256 ◽

Substituted Uracils ◽

Rat Tumor

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Irreversible Enzyme Inhibitors. LXXV.1,2Inhibitors of Thymidine Phosphorylase. I. Mode of Ribofuranose Binding

Journal of Medicinal Chemistry ◽

10.1021/jm00315a001 ◽

1967 ◽

Vol 10 (3) ◽

pp. 297-301 ◽

Cited By ~ 11

Author(s):

B. R. Baker

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors

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Irreversible Enzyme Inhibitors. LXXX.1,2Inhibitors of Thymidine Phosphorylase. VI.2Hydrophobic Bonding with 6 Substituents on the Acidic 5-Nitro- and 5-Bromouracils

Journal of Medicinal Chemistry ◽

10.1021/jm00315a006 ◽

1967 ◽

Vol 10 (3) ◽

pp. 316-320 ◽

Cited By ~ 13

Author(s):

B. R. Baker ◽

Mitsutaka. Kawazu

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors

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Irreversible enzyme inhibitors. CLXIX. Inhibition of FUDR [5-fluoro-2'-deoxyuridine] phosphorylase from Walker 256 rat tumor by 6-substituted uracils

Journal of Medicinal Chemistry ◽

10.1021/jm00297a027 ◽

1970 ◽

Vol 13 (3) ◽

pp. 456-458 ◽

Cited By ~ 8

Author(s):

Bernard Randall Baker ◽

James L. Kelley

Keyword(s):

Enzyme Inhibitors ◽

Walker 256 ◽

Substituted Uracils ◽

Rat Tumor

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Irreversible enzyme inhibitors. CXXI. Thymidine phosphorylase. 9. Nature and dimensions of the hydrophobic bonding region

Journal of Medicinal Chemistry ◽

10.1021/jm00310a001 ◽

1968 ◽

Vol 11 (4) ◽

pp. 639-644 ◽

Cited By ~ 15

Author(s):

B. R. Baker ◽

Waclaw Rzeszotarski

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Hydrophobic Bonding

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Irreversible enzyme inhibitors. 188. Inhibition of mammalian thymidine phosphorylase

Journal of Medicinal Chemistry ◽

10.1021/jm00291a009 ◽

1971 ◽

Vol 14 (9) ◽

pp. 812-816 ◽

Cited By ~ 15

Author(s):

B. R. Baker ◽

James L. Kelley

Keyword(s):

Thymidine Phosphorylase ◽

Enzyme Inhibitors

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Irreversible enzyme inhibitors. CLXX. Inhibition of FUDR [5-fluoro-2'-deoxyuridine] phosphorylase from Walker 256 rat tumor by 1-substituted uracils

Journal of Medicinal Chemistry ◽

10.1021/jm00297a028 ◽

1970 ◽

Vol 13 (3) ◽

pp. 458-461 ◽

Cited By ~ 6

Author(s):

Bernard Randall Baker ◽

James L. Kelley

Keyword(s):

Enzyme Inhibitors ◽

Walker 256 ◽

Substituted Uracils ◽

Rat Tumor

Download Full-text