Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters

1978 ◽  
Vol 21 (2) ◽  
pp. 215-217 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Dennis A. Dougherty ◽  
Tz-Hong Lin ◽  
Archie Khentigan ◽  
James F. Lamb ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Labeled Compounds ◽  
Relationship Of

Relationship of molecular structure to in vivo distribution of carbon-11-labeled compounds

1980 ◽  
Vol 5 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Douglas D. Dischino ◽  
Nancy A. Munder ◽  
Christopher Walsh ◽  
H. Saul Winchell
Keyword(s):  
Molecular Structure ◽  
Labeled Compounds ◽  
In Vivo Distribution ◽  
Relationship Of

Relation of molecular structure to in vivo scintigraphic distribution patterns of carbon-11-labeled compounds. 3. Carbon-11-labeled hydantoins

1976 ◽  
Vol 19 (2) ◽  
pp. 279-286 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Shelley J. Parr ◽  
Michael J. Rogal ◽  
Paul S. Brockman ◽  
Ronald Lubcher ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Distribution Patterns ◽  
Labeled Compounds

Relationship of Molecular Structure to the in Vivo- Distribution of Carbon-11-Labeled Compounds V. Carbon-11-Labeled N-Alkyl-p-Iodobenzenesulfon- amides

1979 ◽  
Vol 18 (03) ◽  
pp. 142-146
Author(s):  
D. Dischino ◽  
H. Winchell ◽  
M. Winstead
Keyword(s):  
Molecular Structure ◽  
Urinary Excretion ◽  
Tissue Concentration ◽  
In Vivo Distribution ◽  
Aliphatic Nitrile ◽  
Radiochemical Yields ◽  
Relationship Of ◽  
The Relationship ◽  
Aliphatic Chains

SummaryCarboni 1-labeled HCN was collected in methanol containing carrier NaCN following bombardment of 99% N2 - 1 % H2 with 22 MeV protons. Ten new N-alkyl-p-iodobenzenesulfonamides were synthesized and labeled with 11C in radiochemical yields averaging 27 % by condensation of p-iodobenzenesulfonyl chloride with the 11C-labeled aliphatic amine obtained by reduction of the intermediate 11C-labeled aliphatic nitrile prepared from Na 11CN and the corresponding alkyl bromide. They were chemically characterized and for nine of them the relationship between their molecular structure and their in vivo-distribution in rats was studied. As the length of the alkyl chain was increased from 2 to 8 carbon atoms, the early concentration of activity in most viscera decreased and the urinary excretion increased. Within this range, chains containing an even number of carbon atoms showed greater early tissue concentration of activity than did chains containing an odd number of carbon atoms. For alkyl chains containing greater than 8 carbon atoms the concentration of activity in some tissues increased and urinary excretion decreased. A possible explanation for the results is offered which postulates that early tissue concentration of activity is related to both total lipophilicity of the sulfonamide as well as to the presence of tissue sulfonamide binding sites whose preferred conformation results in hindered binding of sulfonamides with odd-numbered aliphatic chains to a greater extent than with even-numbered aliphatic chains.

scholarly journals Actin and Microtubules Differently Contribute to Vacuolar Targeting Specificity during the Export from the ER

Membranes ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 299
Author(s):  
Monica De Caroli ◽  
Fabrizio Barozzi ◽  
Luciana Renna ◽  
Gabriella Piro ◽  
Gian-Pietro Di Sansebastiano
Keyword(s):  
Spatial Targeting ◽  
Traffic Regulation ◽  
Emergent Features ◽  
Vacuolar Sorting ◽  
Er Export ◽  
Golgi Network ◽  
Relationship Of ◽  
The Relationship ◽  
Fine Tune

Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation. Considerable advances have been made in recent years in the comprehension of the relationship between the trans-Golgi network/early endosome (TGN/EE) and cytoskeletons, but studies have mainly focused on the transport to and from the plasma membrane. We address here the relationship of the cytoskeleton with different endoplasmic reticulum (ER) export mechanisms toward vacuoles. These emergent features of the plant endomembrane traffic are explored with an in vivo approach, providing clues on the traffic regulation at different levels beyond known proteins’ functions and interactions. We show how traffic of vacuolar markers, characterized by different vacuolar sorting determinants, diverges at the export from the ER, clearly involving different components of the cytoskeleton.

scholarly journals Model compounds-based study on adsorption and dispersion properties of lignin-based superplasticizer

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042098062
Author(s):  
Shuangping Ma ◽  
Qingjun Ding ◽  
Fen Zhou ◽  
Huaxiong Zhu
Keyword(s):  
Molecular Structure ◽  
Zeta Potential ◽  
Model Compound ◽  
Research Work ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Lignin Model Compound ◽  
Structure Activity ◽  
Lignin Model ◽  
Relationship Of

The chemical modifications of lignin-based superplasticizers have attracted extensive attentions during recent years. The comprehending of the structure-activity relationship of lignin-based superplasticizer is important to promote the modification and application research of lignin resources. However, lignin features complex and variable molecular structure, which is not conducive to study on structure-activity relationship of lignin-based superplasticizer as well as development and application of new lignin-based superplasticizer. However, the related research work can be simplified by selecting small molecular compound with appropriate molecular structure as the lignin model compound. This article intends to study the structure-activity relationship of lignin-based superplasticizer by using dihydroeugenol as the lignin model compound. Through the substitution of lignin by dihydroeugenol during the synthesis process, a model compound lignin-based superplasticizer (DAFS) was synthesized. The adsorption and dispersion properties of this superplasticizer and reference sample (LAFS) were investigated by fluidity test, Zeta-potential measurement, Total organic carbon analysis and others. The results suggest that the adsorption behavior of both DAFS and LAFS conformed to the Langmuir isotherms and Pseudo-second order kinetic. In cement paste, added with 1 g/L of LAFS and DAFS, Zeta potential were reduced from +3.5 to −15.2 mV and −18.7 mV, respectively. The substitution of lignin by dihydroeugenol has no significantly influence on the dispersive property, but differences on rheological properties which need to be optimized in the future. All the tests confirmed that dihydroeugenol is suitable to replace lignin on exploring the structure-activity relationship of lignin-based superplasticizer. This research work provides new insight on model study of lignin-based superplasticizer.

In vitro and in vivo evaluation of structure-stability relationship of 111In- and 67Ga-labeled antibody via 1B4M or C-NOTA chelates

1997 ◽  
Vol 24 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Jaetae Lee ◽  
Kayhan Garmestani ◽  
Chuanchu Wu ◽  
Martin W. Brechbiel ◽  
Hye K. Chang ◽  
...  
Keyword(s):  
Structure Stability ◽  
In Vivo Evaluation ◽  
Relationship Of
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