Relation of molecular structure to in vivo scintigraphic distribution patterns of carbon-11-labeled compounds. 3. Carbon-11-labeled hydantoins

1976 ◽  
Vol 19 (2) ◽  
pp. 279-286 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Shelley J. Parr ◽  
Michael J. Rogal ◽  
Paul S. Brockman ◽  
Ronald Lubcher ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Distribution Patterns ◽  
Labeled Compounds

Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters

1978 ◽  
Vol 21 (2) ◽  
pp. 215-217 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Dennis A. Dougherty ◽  
Tz-Hong Lin ◽  
Archie Khentigan ◽  
James F. Lamb ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Labeled Compounds ◽  
Relationship Of

Relationship of molecular structure to in vivo distribution of carbon-11-labeled compounds

1980 ◽  
Vol 5 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Meldrum B. Winstead ◽  
Douglas D. Dischino ◽  
Nancy A. Munder ◽  
Christopher Walsh ◽  
H. Saul Winchell
Keyword(s):  
Molecular Structure ◽  
Labeled Compounds ◽  
In Vivo Distribution ◽  
Relationship Of

β-eye: A benchtop system for in vivo molecular screening of labeled compounds

2021 ◽  
pp. 110034
Author(s):  
E. Fysikopoulos ◽  
M. Rouchota ◽  
M. Georgiou ◽  
C. Sfyris ◽  
N. Cheimarios ◽  
...  
Keyword(s):  
Labeled Compounds ◽  
Molecular Screening

scholarly journals SPECT/CT Assessment of In-Vivo Loading of the Knee Correlates with Polyethylene Deformation in Retrieved Total Knee Arthroplasty

Tomography ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 180-188
Author(s):  
Harry Hothi ◽  
Arianna Cerquiglini ◽  
Lukas Büel ◽  
Johann Henckel ◽  
Lukas B. Moser ◽  
...  
Keyword(s):  
Distribution Patterns ◽  
Tracer Uptake ◽  
Medial Compartment ◽  
Lateral Side ◽  
Imaging Data ◽  
Total Knee Replacements ◽  
Knee Replacements ◽  
Total Knee ◽  
In Vivo Loading

Background: SPECT/CT distribution patterns in patients with total knee replacements have previously been correlated with factors such as time of implantation, implant type and alignment. It is unknown, however, if an increased and more extended bone tracer uptake (BTU) in SPECT/CT, representing loading of the joint, correlates with findings from retrieval studies. The aim of this study was to further understand this subject. Materials and Methods: 62 retrieved TKA were included. SPECT/CT was performed prior to revision. Quantitative and qualitative medio-lateral comparisons of BTU intensity and distribution in the tibia were performed. Retrieval analysis was performed with a micro-CT method to assess the thickness differences between medial and lateral sides of polyethylene inserts with symmetrical designs. Results: In the subgroup of TKA with asymmetrical SPECT/CT distribution, there was a significant correlation between retrieval and medical imaging data (p = 0.0355): patients showing a more extended BTU in the medial compartment also had a significantly thinner insert in the medial compartment, and vice versa in the lateral side. Conclusion: This is the first study comparing BTU distribution patterns and retrieval findings. Our results support the hypothesis that SPECT/CT is able to identify bone activity due to implant position and loading.

scholarly journals Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

2018 ◽  
Vol 217 (9) ◽  
pp. 3127-3139 ◽  
Author(s):  
Xiu-Tang Cheng ◽  
Yu-Xiang Xie ◽  
Bing Zhou ◽  
Ning Huang ◽  
Tamar Farfel-Becker ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Distribution Patterns ◽  
Confocal Imaging ◽  
Lysosomal Hydrolases ◽  
Differential Distribution ◽  
Gradient Fractionation ◽  
Endocytic Compartments ◽  
Lateral Sclerosis

Despite widespread distribution of LAMP1 and the heterogeneous nature of LAMP1-labeled compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive organelles are often referred to as lysosomes. In this study, we use immunoelectron microscopy and confocal imaging to provide quantitative analysis of LAMP1 distribution in various autophagic and endolysosomal organelles in neurons. Our study demonstrates that a significant portion of LAMP1-labeled organelles do not contain detectable lysosomal hydrolases including cathepsins D and B and glucocerebrosidase. A bovine serum albumin–gold pulse–chase assay followed by ultrastructural analysis suggests a heterogeneity of degradative capacity in LAMP1-labeled endolysosomal organelles. Gradient fractionation displays differential distribution patterns of LAMP1/2 and cathepsins D/B in neurons. We further reveal that LAMP1 intensity in familial amyotrophic lateral sclerosis–linked motor neurons does not necessarily reflect lysosomal deficits in vivo. Our study suggests that labeling a set of lysosomal hydrolases combined with various endolysosomal markers would be more accurate than simply relying on LAMP1/2 staining to assess neuronal lysosome distribution, trafficking, and functionality under physiological and pathological conditions.

Engineering highly swellable dual-responsive protein-based injectable hydrogels: the effects of molecular structure and composition in vivo

2017 ◽  
Vol 5 (11) ◽  
pp. 2285-2294 ◽  
Author(s):  
V. H. Giang Phan ◽  
Thavasyappan Thambi ◽  
Bong Sup Kim ◽  
Dai Phu Huynh ◽  
Doo Sung Lee
Keyword(s):  
Molecular Structure ◽  
Phase Transitions ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Injectable Hydrogels ◽  
Dual Responsive ◽  
Gel Phase

Highly swellable, dual-responsive bovine serum albumin (BSA)-based injectable hydrogels that exhibit sol-to-gel phase transitions in response to the physiological pH and temperature have been developed.

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