Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

1990 ◽  
Vol 33 (9) ◽  
pp. 2513-2521 ◽  
Author(s):  
James B. Doherty ◽  
Bonnie M. Ashe ◽  
Peter L. Barker ◽  
Thomas J. Blacklock ◽  
John W. Butcher ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Tert Butyl ◽  
Butyl Esters ◽  
Elastase 1 ◽  
Human Leukocyte Elastase

ChemInform Abstract: Inhibition of Human Leukocyte Elastase. Part 1. Inhibition by C-7-Substituted Cephalosporin tert-Butyl Esters.

ChemInform ◽  
2010 ◽  
Vol 22 (8) ◽  
pp. no-no
Author(s):  
J. B. DOHERTY ◽  
B. M. ASHE ◽  
P. L. BARKER ◽  
T. J. BLACKLOCK ◽  
J. W. BUTCHER ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Tert Butyl ◽  
Butyl Esters ◽  
Human Leukocyte Elastase

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

1992 ◽  
Vol 35 (21) ◽  
pp. 3745-3754 ◽  
Author(s):  
Shrenik K. Shah ◽  
Conrad P. Dorn ◽  
Paul E. Finke ◽  
Jeffrey J. Hale ◽  
William K. Hagmann ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active

ChemInform Abstract: Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase-1. Activity of 3,3-Diethyl-2-azetidinones.

ChemInform ◽  
2010 ◽  
Vol 24 (20) ◽  
pp. no-no
Author(s):  
S. K. SHAH ◽  
C. P. JUN. DORN ◽  
P. E. FINKE ◽  
J. J. HALE ◽  
W. K. HAGMANN ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active

A versatile synthesis of 1,1-dioxo 7-substituted cephems: preparation of the human leukocyte elastase (HLE) inhibitor 1,1-dioxo-trans-7-methoxycephalosporanic acid tert-butyl ester

1989 ◽  
Vol 54 (16) ◽  
pp. 3907-3913 ◽  
Author(s):  
Thomas J. Blacklock ◽  
John W. Butcher ◽  
Paul Sohar ◽  
Theresa Rothauser Lamanec ◽  
Edward J. J. Grabowski
Keyword(s):  
Butyl Ester ◽  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Tert Butyl ◽  
Human Leukocyte Elastase

Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

ChemInform Abstract: FR901451, a Novel Inhibitor of Human Leukocyte Elastase from Flexibacter sp. Part 2. Pharmacological Effect of FR901451.

ChemInform ◽  
2010 ◽  
Vol 26 (23) ◽  
pp. no-no
Author(s):  
T. FUJITA ◽  
Y. SHINGUH ◽  
A. YAMAZAKI ◽  
K. NAKAHARA ◽  
M. OKAMOTO ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Pharmacological Effect ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase
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