Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

Shrenik K. Shah; Conrad P. Dorn; Paul E. Finke; Jeffrey J. Hale; William K. Hagmann; Karen A. Brause; Gilbert O. Chandler; Amy L. Kissinger; Bonnie M. Ashe

doi:10.1021/jm00099a003

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

Journal of Medicinal Chemistry ◽

10.1021/jm00099a003 ◽

1992 ◽

Vol 35 (21) ◽

pp. 3745-3754 ◽

Cited By ~ 50

Author(s):

Shrenik K. Shah ◽

Conrad P. Dorn ◽

Paul E. Finke ◽

Jeffrey J. Hale ◽

William K. Hagmann ◽

...

Keyword(s):

Human Leukocyte ◽

Beta Lactam ◽

Leukocyte Elastase ◽

Elastase 1 ◽

Human Leukocyte Elastase ◽

Orally Active

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Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

Journal of Medicinal Chemistry ◽

10.1021/jm00058a015 ◽

1993 ◽

Vol 36 (6) ◽

pp. 771-777 ◽

Cited By ~ 17

Author(s):

William K. Hagmann ◽

Amy L. Kissinger ◽

Shrenik K. Shah ◽

Paul E. Finke ◽

Conrad P. Dorn ◽

...

Keyword(s):

Human Leukocyte ◽

Beta Lactam ◽

Leukocyte Elastase ◽

Human Leukocyte Elastase ◽

Orally Active

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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

Journal of Medicinal Chemistry ◽

10.1021/jm00013a021 ◽

1995 ◽

Vol 38 (13) ◽

pp. 2449-2462 ◽

Cited By ~ 61

Author(s):

Paul E. Finke ◽

Shrenik K. Shah ◽

Daniel S. Fletcher ◽

Bonnie M. Ashe ◽

Karen A. Brause ◽

...

Keyword(s):

Human Leukocyte ◽

Stereospecific Synthesis ◽

Beta Lactam ◽

Leukocyte Elastase ◽

Structure Activity Relationships ◽

Structure Activity ◽

Human Leukocyte Elastase ◽

Orally Active

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ChemInform Abstract: Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase-1. Activity of 3,3-Diethyl-2-azetidinones.

ChemInform ◽

10.1002/chin.199320171 ◽

2010 ◽

Vol 24 (20) ◽

pp. no-no

Author(s):

S. K. SHAH ◽

C. P. JUN. DORN ◽

P. E. FINKE ◽

J. J. HALE ◽

W. K. HAGMANN ◽

...

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Elastase 1 ◽

Human Leukocyte Elastase ◽

Orally Active

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Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Biochemistry ◽

10.1021/bi00150a007 ◽

1992 ◽

Vol 31 (35) ◽

pp. 8160-8170 ◽

Cited By ~ 33

Author(s):

W. B. Knight ◽

B. G. Green ◽

R. M. Chabin ◽

P. Gale ◽

A. L. Maycock ◽

...

Keyword(s):

Human Leukocyte ◽

Beta Lactam ◽

Leukocyte Elastase ◽

Human Leukocyte Elastase

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Mechanism of Inhibition of Human Leukocyte Elastase by .beta.-Lactams. 2. Stability, Reactivation Kinetics, and Products of .beta.-Lactam-Derived E-I Complexes

Biochemistry ◽

10.1021/bi00044a010 ◽

1995 ◽

Vol 34 (44) ◽

pp. 14331-14343 ◽

Cited By ~ 14

Author(s):

B. G. Green ◽

R. Chabin ◽

S. Mills ◽

D. J. Underwood ◽

S. K. Shah ◽

...

Keyword(s):

Human Leukocyte ◽

Beta Lactam ◽

Beta Lactams ◽

Leukocyte Elastase ◽

Mechanism Of Inhibition ◽

Human Leukocyte Elastase

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Synthetic Macromolecular Inhibitors of Human Leukocyte Elastase. 1. Synthesis of Peptidyl Carbamates Bound to Water-Soluble Polymers: Poly-.alpha.,.beta.-[N-(2-hydroxyethyl)-D,L-aspartamide] and Poly-.alpha.-[N5-(2-hydroxyethyl)-L-glutamine]

Journal of Medicinal Chemistry ◽

10.1021/jm00038a014 ◽

1994 ◽

Vol 37 (12) ◽

pp. 1850-1856 ◽

Cited By ~ 5

Author(s):

Frantisek Rypacek ◽

William R. Banks ◽

Dagmar Noskova ◽

George A. Digenis

Keyword(s):

Human Leukocyte ◽

Water Soluble ◽

Leukocyte Elastase ◽

Water Soluble Polymers ◽

Soluble Polymers ◽

Elastase 1 ◽

Human Leukocyte Elastase ◽

Alpha Beta

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Electrospray ionization mass spectrometry as a mechanistic tool: Mass of human leukocyte elastase and a .beta.-lactam-derived E-I complex

Biochemistry ◽

10.1021/bi00059a020 ◽

1993 ◽

Vol 32 (8) ◽

pp. 2031-2035 ◽

Cited By ~ 32

Author(s):

W. B. Knight ◽

K. M. Swiderek ◽

T. Sakuma ◽

J. Calaycay ◽

J. E. Shively ◽

...

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Electrospray Ionization Mass Spectrometry ◽

Human Leukocyte ◽

Ionization Mass Spectrometry ◽

Ionization Mass ◽

Beta Lactam ◽

Leukocyte Elastase ◽

Human Leukocyte Elastase

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Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase

Journal of Medicinal Chemistry ◽

10.1021/jm00035a004 ◽

1994 ◽

Vol 37 (9) ◽

pp. 1259-1261 ◽

Cited By ~ 40

Author(s):

Frederick J. Brown ◽

Donald W. Andisik ◽

Peter R. Bernstein ◽

Craig B. Bryant ◽

Chris Ceccarelli ◽

...

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Human Leukocyte Elastase ◽

Peptidic Inhibitors ◽

Orally Active

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Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase

Journal of Medicinal Chemistry ◽

10.1021/jm970250z ◽

1997 ◽

Vol 40 (20) ◽

pp. 3173-3181 ◽

Cited By ~ 36

Author(s):

Chris A. Veale ◽

Peter R. Bernstein ◽

Claudia M. Bohnert ◽

Frederick J. Brown ◽

Craig Bryant ◽

...

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Human Leukocyte Elastase ◽

Orally Active

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ChemInform Abstract: Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase. Part 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones.

ChemInform ◽

10.1002/chin.199542123 ◽

2010 ◽

Vol 26 (42) ◽

pp. no-no

Author(s):

P. E. FINKE ◽

S. K. SHAH ◽

D. S. FLETCHER ◽

B. M. ASHE ◽

K. A. BRAUSE ◽

...

Keyword(s):

Human Leukocyte ◽

Stereospecific Synthesis ◽

Leukocyte Elastase ◽

Structure Activity Relationships ◽

Structure Activity ◽

Human Leukocyte Elastase ◽

Orally Active

Download Full-text