(.+-.)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a new high affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship

John L. Neumeyer; Nandkishore Baindur; Hyman B. Niznik; H. C. Guan; Philip Seeman

doi:10.1021/jm00116a004

(.+-.)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a new high affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship

Journal of Medicinal Chemistry ◽

10.1021/jm00116a004 ◽

1991 ◽

Vol 34 (12) ◽

pp. 3366-3371 ◽

Cited By ~ 18

Author(s):

John L. Neumeyer ◽

Nandkishore Baindur ◽

Hyman B. Niznik ◽

H. C. Guan ◽

Philip Seeman

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Ligand ◽

High Affinity ◽

Structure Activity ◽

D1 Dopamine Receptor ◽

Ligand Synthesis

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(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

Journal of Medicinal Chemistry ◽

10.1021/jm00079a008 ◽

1992 ◽

Vol 35 (1) ◽

pp. 67-72 ◽

Cited By ~ 17

Author(s):

Nandkishore Baindur ◽

Mai Tran ◽

Hyman B. Niznik ◽

H. C. Guan ◽

Phillip Seeman ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

High Affinity ◽

Dopamine Receptor Antagonists ◽

Structure Activity ◽

D1 Dopamine Receptor

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ChemInform Abstract: (.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepines as Selective High Affinity D1 Dopamine Receptor Antagonists: Synthesis and Structure-Activity Relationship.

ChemInform ◽

10.1002/chin.199222203 ◽

2010 ◽

Vol 23 (22) ◽

pp. no-no

Author(s):

N. BAINDUR ◽

M. TRAN ◽

H. B. NIZNIK ◽

H. C. GUAN ◽

P. SEEMAN ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

High Affinity ◽

Dopamine Receptor Antagonists ◽

Structure Activity ◽

D1 Dopamine Receptor

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Structure-Activity Relationship of Nuclear Receptor-Ligand Interactions

Current Topics in Medicinal Chemistry ◽

10.2174/1568026033451736 ◽

2003 ◽

Vol 3 (14) ◽

pp. 1573-1599 ◽

Cited By ~ 39

Author(s):

Holger Greschik ◽

Dino Moras

Keyword(s):

Nuclear Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Ligand ◽

Structure Activity ◽

Ligand Interactions ◽

Relationship Of

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Compounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen)

Journal of Medicinal Chemistry ◽

10.1021/jm00109a022 ◽

1991 ◽

Vol 34 (5) ◽

pp. 1675-1692 ◽

Cited By ~ 53

Author(s):

Hson Mou Chang ◽

Kuk Ying Chui ◽

Fan Wah Lau Tan ◽

Yun Yang ◽

Zeng Pei Zhong ◽

...

Keyword(s):

Salvia Miltiorrhiza ◽

Benzodiazepine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Salvia Miltiorrhiza Bunge ◽

Receptor Ligand ◽

Structure Activity ◽

Central Benzodiazepine Receptor ◽

Relationship Of

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Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against hydrogen-bonding and provides an esterase-resistant, high-affinity cocaine

Journal of Medicinal Chemistry ◽

10.1021/jm00103a015 ◽

1992 ◽

Vol 35 (25) ◽

pp. 4764-4766 ◽

Cited By ~ 29

Author(s):

Alan P. Kozikowski ◽

Marinella Roberti ◽

Li Xiang ◽

John S. Bergmann ◽

Patrick M. Callahan ◽

...

Keyword(s):

Hydrogen Bonding ◽

Ester Group ◽

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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Design, Synthesis and Structure—Activity Relationship Studies of Hexahydropyrazinoquinolines as a Novel Class of Potent and Selective Dopamine Receptor 3 (D3) Ligands.

ChemInform ◽

10.1002/chin.200529170 ◽

2005 ◽

Vol 36 (29) ◽

Author(s):

Min Ji ◽

Jianyong Chen ◽

Ke Ding ◽

Xihan Wu ◽

Judith Varady ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Selective Dopamine

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Quantitative structure-activity relationship study on the binding affinity of some aminothiazole derivatives with a dopamine receptor in brain

Journal of Structural Chemistry ◽

10.1134/s0022476617020159 ◽

2017 ◽

Vol 58 (2) ◽

pp. 344-348

Author(s):

M. Mahani ◽

S. Sheikhghomi ◽

H. Sheikhghomi ◽

J. Fasihi

Keyword(s):

Dopamine Receptor ◽

Binding Affinity ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Study

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Synthesis and structure–activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor–ligand

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.12.040 ◽

2010 ◽

Vol 18 (3) ◽

pp. 1149-1162 ◽

Cited By ~ 14

Author(s):

Hee Jeong Seo ◽

Min Ju Kim ◽

Suk Ho Lee ◽

Sung-Han Lee ◽

Myung Eun Jung ◽

...

Keyword(s):

Cannabinoid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Ligand ◽

Cb1 Cannabinoid Receptor ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: Structure-Activity Relationship Studies of CNS Agents. Part 26. 4-(2-( Cycloalkanecarboxamido)ethyl)-1-(2-methoxyphenyl)-piperazines: High- Affinity 5-HT1A Agonists

ChemInform ◽

10.1002/chin.199614177 ◽

2010 ◽

Vol 27 (14) ◽

pp. no-no

Author(s):

J. L. MOKROSZ ◽

M. H. PALUCHOWSKA ◽

A. KLODZINSKA ◽

S. CHARAKCHIEVA-MINOL ◽

E. CHOJNACKA-WOJCIK

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity ◽

Abstract Structure

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Structure-Activity Relationship Studies of CNS Agents, Part 26 4-[2-(Cycloalkanecarboxamido)ethyl]-1-(2-methoxyphenyl)-piperazines: High-Affinity 5-HT1A Agonists

Archiv der Pharmazie ◽

10.1002/ardp.19953281108 ◽

1995 ◽

Vol 328 (11-12) ◽

pp. 770-774 ◽

Cited By ~ 10

Author(s):

Jerzy L. Mokrosz ◽

Maria H. Paluchowska ◽

Aleksandra Klodzińska ◽

Sijka Charakchieva-Minol ◽

Ewa Chojnacka-Wójcik

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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