Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against hydrogen-bonding and provides an esterase-resistant, high-affinity cocaine

Alan P. Kozikowski; Marinella Roberti; Li Xiang; John S. Bergmann; Patrick M. Callahan; Kathryn A. Cunningham; Kenneth M. Johnson

doi:10.1021/jm00103a015

Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against hydrogen-bonding and provides an esterase-resistant, high-affinity cocaine

Journal of Medicinal Chemistry ◽

10.1021/jm00103a015 ◽

1992 ◽

Vol 35 (25) ◽

pp. 4764-4766 ◽

Cited By ~ 29

Author(s):

Alan P. Kozikowski ◽

Marinella Roberti ◽

Li Xiang ◽

John S. Bergmann ◽

Patrick M. Callahan ◽

...

Keyword(s):

Hydrogen Bonding ◽

Ester Group ◽

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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ChemInform Abstract: Structure-Activity Relationship Studies of CNS Agents. Part 26. 4-(2-( Cycloalkanecarboxamido)ethyl)-1-(2-methoxyphenyl)-piperazines: High- Affinity 5-HT1A Agonists

ChemInform ◽

10.1002/chin.199614177 ◽

2010 ◽

Vol 27 (14) ◽

pp. no-no

Author(s):

J. L. MOKROSZ ◽

M. H. PALUCHOWSKA ◽

A. KLODZINSKA ◽

S. CHARAKCHIEVA-MINOL ◽

E. CHOJNACKA-WOJCIK

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity ◽

Abstract Structure

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Structure-Activity Relationship Studies of CNS Agents, Part 26 4-[2-(Cycloalkanecarboxamido)ethyl]-1-(2-methoxyphenyl)-piperazines: High-Affinity 5-HT1A Agonists

Archiv der Pharmazie ◽

10.1002/ardp.19953281108 ◽

1995 ◽

Vol 328 (11-12) ◽

pp. 770-774 ◽

Cited By ~ 10

Author(s):

Jerzy L. Mokrosz ◽

Maria H. Paluchowska ◽

Aleksandra Klodzińska ◽

Sijka Charakchieva-Minol ◽

Ewa Chojnacka-Wójcik

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

Journal of Medicinal Chemistry ◽

10.1021/jm00083a014 ◽

1992 ◽

Vol 35 (5) ◽

pp. 895-903 ◽

Cited By ~ 17

Author(s):

R. D. Youssefyeh ◽

H. F. Campbell ◽

S. Klein ◽

J. E. Airey ◽

P. Darkes ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Initial Structure ◽

Receptor Antagonists ◽

High Affinity ◽

Structure Activity ◽

Relationship Of

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High-Affinity α-Aminobutyric Acid A/Benzodiazepine Ligands: Synthesis and Structure−Activity Relationship Studies of a New Series of Tetracyclic Imidazoquinoxalines†

Journal of Medicinal Chemistry ◽

10.1021/jm960401i ◽

1996 ◽

Vol 39 (23) ◽

pp. 4654-4666 ◽

Cited By ~ 30

Author(s):

John W. Mickelson ◽

E. Jon Jacobsen ◽

Donald B. Carter ◽

Haesook K. Im ◽

Wha Bin Im ◽

...

Keyword(s):

Structure Activity Relationship ◽

Aminobutyric Acid ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

Journal of Medicinal Chemistry ◽

10.1021/jm00079a008 ◽

1992 ◽

Vol 35 (1) ◽

pp. 67-72 ◽

Cited By ~ 17

Author(s):

Nandkishore Baindur ◽

Mai Tran ◽

Hyman B. Niznik ◽

H. C. Guan ◽

Phillip Seeman ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

High Affinity ◽

Dopamine Receptor Antagonists ◽

Structure Activity ◽

D1 Dopamine Receptor

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Quantitative Structure–Activity Relationship for High Affinity 5-HT1A Receptor Ligands Based on Norm Indexes

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.5b08980 ◽

2015 ◽

Vol 119 (51) ◽

pp. 15561-15567 ◽

Cited By ~ 17

Author(s):

Qingzhu Jia ◽

Xue Cui ◽

Lei Li ◽

Qiang Wang ◽

Ying Liu ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Ligands ◽

High Affinity ◽

Structure Activity

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Synthesis, Antibacterial Activity and Structure-Activity Relationship of 1H-2,5-Dihydro-1,5-benzodiazepine with Ester Group and the Aromatic Heterocyclic Ring

Chinese Journal of Organic Chemistry ◽

10.6023/cjoc201604059 ◽

2017 ◽

Vol 37 (2) ◽

pp. 462

Author(s):

Xiujun Zhang ◽

Lanzhi Wang ◽

Jingyi Yan ◽

Chen Gao

Keyword(s):

Antibacterial Activity ◽

Heterocyclic Ring ◽

Ester Group ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Aromatic Heterocyclic

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ChemInform Abstract: (.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepines as Selective High Affinity D1 Dopamine Receptor Antagonists: Synthesis and Structure-Activity Relationship.

ChemInform ◽

10.1002/chin.199222203 ◽

2010 ◽

Vol 23 (22) ◽

pp. no-no

Author(s):

N. BAINDUR ◽

M. TRAN ◽

H. B. NIZNIK ◽

H. C. GUAN ◽

P. SEEMAN ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

High Affinity ◽

Dopamine Receptor Antagonists ◽

Structure Activity ◽

D1 Dopamine Receptor

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Design of Platinum Complexes with High Affinity for Osteosarcoma and Bone Metastases — Structure-Activity Relationship

Contributions to Oncology - Relevance of Tumor Models for Anticancer Drug Development ◽

10.1159/000425835 ◽

1999 ◽

pp. 201-205 ◽

Cited By ~ 3

Author(s):

S. Slaby ◽

M. Galanski ◽

S. W. Metzger ◽

B. K. Keppler

Keyword(s):

Bone Metastases ◽

Platinum Complexes ◽

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

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Structure-activity relationship study of a scorpion toxin with high affinity for apamin-sensitive potassium channels by means of the solution structure of analogues

International journal of peptide & protein research ◽

10.1111/j.1399-3011.1995.tb01059.x ◽

2009 ◽

Vol 45 (5) ◽

pp. 441-450 ◽

Cited By ~ 15

Author(s):

A.G. INISAN ◽

S. MEUNIER ◽

O. FEDELLI ◽

M. ALTBACH ◽

V. FREMONT ◽

...

Keyword(s):

Potassium Channels ◽

Solution Structure ◽

Structure Activity Relationship ◽

Scorpion Toxin ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity ◽

Relationship Study

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