Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine

1992 ◽  
Vol 35 (16) ◽  
pp. 2958-2969 ◽  
Author(s):  
Kuo Long Yu ◽  
Joanne J. Bronson ◽  
Hyekyung Yang ◽  
Amy Patick ◽  
Masud Alam ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity

1987 ◽  
Vol 52 (3) ◽  
pp. 788-792 ◽  
Author(s):  
Stanislav Rádl ◽  
Viktor Zikán
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Hydrobromic Acid ◽  
Encephalomyocarditis Virus ◽  
Methyl Derivative ◽  
Pyridine Hydrochloride ◽  
Methyl Derivatives ◽  
Derivatives Of

The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demethylation of Ie and/or IIc with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and encephalomyocarditis virus.

Synthesis and antiviral activity of 2-amino[thio]methyl derivatives of 4,5-dihydroxybenzofuran

1987 ◽  
Vol 21 (2) ◽  
pp. 132-133
Author(s):  
A. N. Grinev ◽  
V. M. Lyubchanskaya ◽  
L. S. Sarkisova ◽  
S. A. Moshinets ◽  
E. A. Golovanova
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

Syntheses of 1, 2, and 9-methyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity

1985 ◽  
Vol 50 (5) ◽  
pp. 1057-1063 ◽  
Author(s):  
Stanislav Rádl ◽  
Viktor Zikán ◽  
František Šmejkal
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Methyl Iodide ◽  
Room Temperature ◽  
Encephalomyocarditis Virus ◽  
Methyl Derivative ◽  
Sodium Salts ◽  
Methyl Derivatives ◽  
Derivatives Of

The paper describes syntheses of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ib), 2-methyl derivative (IIa), 9-methyl derivative (Ic), 1,9-dimethyl derivative (Id) and 2,9-dimethyl derivative (IIb). Sodium salts of compounds Ia, Ib, Ic and IIa were methylated with methyl iodide in dimethylformamide at room temperature, compounds Id and IIb were demethylated with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and the Encephalomyocarditis virus.

ChemInform Abstract: Synthesis and Antiviral Activity of 2-Amino(Thio)methyl Derivatives of 4,5-Dihydroxybenzofuran.

ChemInform ◽  
1987 ◽  
Vol 18 (37) ◽  
Author(s):  
A. N. GRINEV ◽  
V. M. LYUBCHANSKAYA ◽  
L. S. SARKISOVA ◽  
S. A. MOSHINETS ◽  
E. A. GOLOVANOVA
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antiviral Activity of Methyl Derivatives of 9-(2-( Phosphonomethoxy)ethyl)guanine.

ChemInform ◽  
2010 ◽  
Vol 23 (52) ◽  
pp. no-no
Author(s):  
K.-L. YU ◽  
J. J. BRONSON ◽  
H. YANG ◽  
A. PATICK ◽  
M. ALAM ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

Physical Properties of TCNQ Salts with N-Methyl Derivatives of Pyridine

1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik
Keyword(s):  
Physical Properties ◽  
Methyl Derivatives ◽  
Derivatives Of
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