Phenolic P2/P3 Core Motif as Thrombin Inhibitors — Design, Synthesis, and X-Ray Co-Crystal Structure.

Stephen Hanessian; Eric Therrien; Willem A. L. van Otterlo; Malken Bayrakdarian; Ingemar Nilsson; Ola Fjellstroem; Yafeng Xue

doi:10.1002/chin.200619076

Phenolic P2/P3 Core Motif as Thrombin Inhibitors — Design, Synthesis, and X-Ray Co-Crystal Structure.

ChemInform ◽

10.1002/chin.200619076 ◽

2006 ◽

Vol 37 (19) ◽

Author(s):

Stephen Hanessian ◽

Eric Therrien ◽

Willem A. L. van Otterlo ◽

Malken Bayrakdarian ◽

Ingemar Nilsson ◽

...

Keyword(s):

Crystal Structure ◽

Thrombin Inhibitors ◽

Design Synthesis ◽

Core Motif ◽

X Ray

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Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.10.082 ◽

2006 ◽

Vol 16 (4) ◽

pp. 1032-1036 ◽

Cited By ~ 11

Author(s):

Stephen Hanessian ◽

Eric Therrien ◽

Willem A.L. van Otterlo ◽

Malken Bayrakdarian ◽

Ingemar Nilsson ◽

...

Keyword(s):

Crystal Structure ◽

Thrombin Inhibitors ◽

Design Synthesis ◽

Core Motif ◽

X Ray

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Novel Morpholinone-Based ?-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(02)00023-8 ◽

2002 ◽

Vol 10 (6) ◽

pp. 1829-1839 ◽

Cited By ~ 10

Author(s):

A Dahlgren

Keyword(s):

Crystal Structure ◽

Enzyme Inhibitor ◽

Thrombin Inhibitors ◽

Design Synthesis ◽

X Ray ◽

Inhibitor Complex

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Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

Journal of Medicinal Chemistry ◽

10.1021/jm000200l ◽

2000 ◽

Vol 43 (21) ◽

pp. 3837-3851 ◽

Cited By ~ 44

Author(s):

Aleem Gangjee ◽

Jianming Yu ◽

John J. McGuire ◽

Vivian Cody ◽

Nikolai Galitsky ◽

...

Keyword(s):

Crystal Structure ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Dual Inhibitor ◽

Design Synthesis ◽

X Ray

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Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex

Journal of Medicinal Chemistry ◽

10.1021/jm0307990 ◽

2003 ◽

Vol 46 (19) ◽

pp. 3985-4001 ◽

Cited By ~ 15

Author(s):

Jonas W. Nilsson ◽

Ingemar Kvarnström ◽

Djordje Musil ◽

Ingemar Nilsson ◽

Bertil Samulesson

Keyword(s):

Crystal Structure ◽

Enzyme Inhibitor ◽

Thrombin Inhibitors ◽

X Ray ◽

Inhibitor Complex

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Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.02.008 ◽

2019 ◽

Vol 29 (8) ◽

pp. 1012-1018 ◽

Cited By ~ 5

Author(s):

Kai Cheng ◽

Shiyu Li ◽

Xiao Lv ◽

Yongbin Tian ◽

Haiyan Kong ◽

...

Keyword(s):

Crystal Structure ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

X Ray ◽

Synthesis And Biological Evaluation

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Design, synthesis and characterization of picoline based organoselenium compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal structure of 1,2-bis(pyridine-3-yl)methyldiselane

Journal of Organometallic Chemistry ◽

10.1016/j.jorganchem.2015.02.024 ◽

2015 ◽

Vol 785 ◽

pp. 19-25 ◽

Cited By ~ 8

Author(s):

A.K.K. Bhasin ◽

C. Jacob ◽

F. Sasse ◽

K. Karaghiosoff ◽

K.K. Bhasin ◽

...

Keyword(s):

Crystal Structure ◽

Synthesis And Characterization ◽

Organoselenium Compounds ◽

Design Synthesis ◽

X Ray

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Metal-metal double bond formation via steric design. Synthesis and x-ray crystal structure of [Rh(.mu.-tert-Bu2P)(CO)(PMe3)]2(Rh:Rh)

Organometallics ◽

10.1021/om50006a024 ◽

1983 ◽

Vol 2 (12) ◽

pp. 1842-1845 ◽

Cited By ~ 25

Author(s):

Richard A. Jones ◽

Thomas C. Wright

Keyword(s):

Crystal Structure ◽

Double Bond ◽

Bond Formation ◽

Design Synthesis ◽

X Ray ◽

Metal Metal

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Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01522 ◽

2021 ◽

Author(s):

Jie Zhou ◽

Ming Ji ◽

Xiaoyu Wang ◽

Hailong Zhao ◽

Ran Cao ◽

...

Keyword(s):

Crystal Structure ◽

Antitumor Activity ◽

Structure Analysis ◽

Crystal Structure Analysis ◽

Design Synthesis ◽

X Ray ◽

In Vivo Antitumor Activity ◽

Parp 1

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Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.04.004 ◽

2016 ◽

Vol 118 ◽

pp. 170-177 ◽

Cited By ~ 17

Author(s):

Yannick J. Esvan ◽

Wael Zeinyeh ◽

Thibaut Boibessot ◽

Lionel Nauton ◽

Vincent Théry ◽

...

Keyword(s):

Crystal Structure ◽

Protein Kinase ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Inhibitory Potency ◽

Design Synthesis ◽

X Ray ◽

Family Protein ◽

Quinazoline Derivatives

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Design, Synthesis, and X-Ray Crystal Structure of a Fullerene-Linked Metal-Organic Framework

Angewandte Chemie ◽

10.1002/ange.201306761 ◽

2013 ◽

Vol 126 (1) ◽

pp. 164-167 ◽

Cited By ~ 7

Author(s):

Ping Peng ◽

Fang-Fang Li ◽

Venkata S. Pavan K. Neti ◽

Alejandro J. Metta-Magana ◽

Luis Echegoyen

Keyword(s):

Crystal Structure ◽

Metal Organic Framework ◽

Design Synthesis ◽

X Ray ◽

Metal Organic ◽

Organic Framework

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