Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and x-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones

1995 ◽  
Vol 38 (1) ◽  
pp. 98-108 ◽  
Author(s):  
Chris A. Veale ◽  
Peter R. Bernstein ◽  
Craig Bryant ◽  
Christopher Ceccarelli ◽  
James R. Jr. Damewood ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
X Ray ◽  
X Ray Crystallography ◽  
Trifluoromethyl Ketones ◽  
Human Leukocyte Elastase ◽  
Orally Active

Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

1993 ◽  
Vol 36 (6) ◽  
pp. 771-777 ◽  
Author(s):  
William K. Hagmann ◽  
Amy L. Kissinger ◽  
Shrenik K. Shah ◽  
Paul E. Finke ◽  
Conrad P. Dorn ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

1992 ◽  
Vol 35 (21) ◽  
pp. 3745-3754 ◽  
Author(s):  
Shrenik K. Shah ◽  
Conrad P. Dorn ◽  
Paul E. Finke ◽  
Jeffrey J. Hale ◽  
William K. Hagmann ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active
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