Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-phenyl-2-pyridinyl Trifluoromethyl Ketones

1994 ◽  
Vol 37 (20) ◽  
pp. 3313-3326 ◽  
Author(s):  
Peter R. Bernstein ◽  
Don Andisik ◽  
Prudence K. Bradley ◽  
Craig B. Bryant ◽  
Christopher Ceccarelli ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Crystallographic Analysis ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
X Ray ◽  
Structure Activity Relationships ◽  
Trifluoromethyl Ketones ◽  
Structure Activity ◽  
Human Leukocyte Elastase ◽  
Orally Active

Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase
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