Structure−Activity Relationships of (1‘S)-1‘-Acetoxychavicol Acetate, a Major Constituent of a Southeast Asian Condiment PlantLanguasgalanga, on the Inhibition of Tumor-Promoter-Induced Epstein−Barr Virus Activation

2000 ◽  
Vol 48 (5) ◽  
pp. 1518-1523 ◽  
Author(s):  
Akira Murakami ◽  
Kazuo Toyota ◽  
Shin Ohura ◽  
Koichi Koshimizu ◽  
Hajime Ohigashi
1999 ◽  
Vol 42 (12) ◽  
pp. 2212-2217 ◽  
Author(s):  
Ju-Sheng Lin ◽  
Toshihiko Kira ◽  
Elizabeth Gullen ◽  
Yongseok Choi ◽  
Fucheng Qu ◽  
...  

2000 ◽  
Vol 78 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hironori Ohtsu ◽  
Reiko Tanaka ◽  
Yasuko In ◽  
Shunyo Matsunaga ◽  
Harukuni Tokuda ◽  
...  

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.


1993 ◽  
Vol 57 (8) ◽  
pp. 1344-1345 ◽  
Author(s):  
Akira Kondo ◽  
Hajime Ohigashi ◽  
Akira Murakami ◽  
Jiwajinda Suratwadee ◽  
Koichi Koshimizu

1990 ◽  
Vol 17 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Mitsuru Furukawa ◽  
Hideo Sakashita ◽  
Michihiro Kamide ◽  
Ryozo Umeda

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