Inhibitory Effects of Cucurbitane Glycosides and Other Triterpenoids from the Fruit ofMomordica grosvenorion Epstein−Barr Virus Early Antigen Induced by Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate

2002 ◽  
Vol 50 (23) ◽  
pp. 6710-6715 ◽  
Author(s):  
Motohiko Ukiya ◽  
Toshihiro Akihisa ◽  
Harukuni Tokuda ◽  
Masakazu Toriumi ◽  
Teruo Mukainaka ◽  
...  
2000 ◽  
Vol 78 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hironori Ohtsu ◽  
Reiko Tanaka ◽  
Yasuko In ◽  
Shunyo Matsunaga ◽  
Harukuni Tokuda ◽  
...  

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.


1993 ◽  
Vol 68 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ichiro Honda ◽  
Harukuni Tokuda ◽  
Mutsuo Kozuka ◽  
Koichi Yoneyama ◽  
Hoyoku Nishino ◽  
...  

1991 ◽  
Vol 59 (2) ◽  
pp. 83-88 ◽  
Author(s):  
I. Honda ◽  
H. Tokuda ◽  
M. Kozuka ◽  
K. Yoneyama ◽  
H. Nishino ◽  
...  

1990 ◽  
Vol 17 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Mitsuru Furukawa ◽  
Hideo Sakashita ◽  
Michihiro Kamide ◽  
Ryozo Umeda

1987 ◽  
Vol 51 (3) ◽  
pp. 941-943 ◽  
Author(s):  
Yutaka SAITO ◽  
Yasuko TSUJINO ◽  
Hajime KANEKO ◽  
Daisuke YOSHIDA ◽  
Shigenobu MIZUSAKI

2003 ◽  
Vol 66 (8) ◽  
pp. 1047-1050 ◽  
Author(s):  
Ignacio A. Jiménez ◽  
Isabel L. Bazzocchi ◽  
Marvin J. Núñez ◽  
Teruo Mukainaka ◽  
Harukuni Tokuda ◽  
...  

1997 ◽  
Vol 45 (4) ◽  
pp. 675-677 ◽  
Author(s):  
Shakila RAHMAN ◽  
Narihiko FUKAMIYA ◽  
Nobuhiro OHNO ◽  
Harukuni TOKUDA ◽  
Hoyoku NISHINO ◽  
...  

1998 ◽  
Vol 134 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Noriko Motohashi ◽  
Chisako Yamagami ◽  
Harukuni Tokuda ◽  
Takao Konoshima ◽  
Yoko Okuda ◽  
...  

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