Yerba Maté (Ilex paraguariensis) Aqueous Extract Decreases Intestinal SGLT1 Gene Expression but Does Not Affect Other Biochemical Parameters in Alloxan-Diabetic Wistar Rats

2008 ◽  
Vol 56 (22) ◽  
pp. 10527-10532 ◽  
Author(s):  
Daniela M. Oliveira ◽  
Helayne S. Freitas ◽  
Marina F. F. Souza ◽  
Demetrius P. Arçari ◽  
Marcelo L. Ribeiro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Ilex Paraguariensis

The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra-abdominal and epididymal fat and glucose levels in male Wistar rats

Fitoterapia ◽  
2011 ◽  
Vol 82 (6) ◽  
pp. 818-826 ◽  
Author(s):  
Raquel D'Agostini Silva ◽  
Audrin Loss Scopel Bueno ◽  
Carin Weirich Gallon ◽  
Luana Ferreira Gomes ◽  
Samuel Kaiser ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Ilex Paraguariensis ◽  
Yerba Mate ◽  
Glucose Levels ◽  
Epididymal Fat ◽  
Male Wistar Rats

scholarly journals Evaluation of Hepatoprotective Activity of Caralluma europaea Stem Extract against CCl4-Induced Hepatic Damage in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hayat Ouassou ◽  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hassane Mekhfi ◽  
Abderrahim Ziyyat ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Hepatoprotective Effect ◽  
Low Density

The present study aims to evaluate the hepatoprotective activity of stem aqueous extract of Caralluma europaea (AECe) on carbon tetrachloride- (CCl4-) induced hepatic damage in Wistar rats. The animals were daily treated with the aqueous extract of C. europaea at a dose of 250 mg/kg body weight for 14 days. CCl4 was injected (1 ml/kg, i.p.) two times, on the 7th and 14th days. At the end of the experimental period, all rats were anesthetized to collect blood for the assessment of biochemical parameters and then sacrificed to collect the liver for weighing. Hepatotoxicity was evaluated by measuring the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin (total and direct), malondialdehyde (MDA), total protein (TP), triglycerides (TG), total cholesterol, very low-density lipoprotein (VLDL-c ), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), urea, creatinine, and uric acid. Based on the results obtained in this study, the administration of C. europaea before exposure to the administration of CCl4 conferred favorable hepatoprotective effect in rats. The treatment with AECe (250 mg/kg) exhibits a significant hepatoprotective effect by ameliorating CCl4-induced alterations of these biochemical parameters. Hence, C. europaea could be a potential medicinal herb that can be used in the future to prevent liver intoxication.

scholarly journals Aqueous Extract of Zingiber officinale Roscoe Rhizomes Sold in Ouagadougou Markets: Phytochemical Constituents, Effect on Arterial Pressure and Blood Biochemical Parameters of Wistar Rats

2020 ◽  
pp. 50-58
Author(s):  
Larba Colette Tougouma ◽  
Youssoufou Ouédraogo ◽  
Abel Andouormwine Somé ◽  
Lazare Belemnaba
Keyword(s):  
Arterial Pressure ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Antihypertensive Effect ◽  
Colorimetric Method ◽  
Zingiber Officinale ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Phytochemical Constituents

The aim of this study was to exhibit cardiovascular effects of aqueous extract of Zingiber officinale rhizome sold in Ouagadougou markets (Burkina Faso). Phytochemical constituents and some blood biochemical parameters were also investigated. Colorimetric method was used for phytochemical screening. Extract was prepared and orally administered on Wistar rats. Arterial pressure and cardiac rhythm were measured using Ugo Basile Blood Pressure Recorder 58500. Biochemical parameters were performed using Mindray BA-88A, Semi-auto Chemistry Analyzer. Triterpenes and/or sterols, and saponosides were present in aqueous extract of the plant. We also found very significative hypotension effect on rat mean arterial pressure, when plant extract was administered at 400 mg/kg bw (p ˂ 0.01). When extract was administered after a hypertension induced by L-NAME, we observed a high significative antihypertensive effect (p ˂ 0.001) at 200 and 400 mg/kg bw. This effect was comparable to captopril inhibition of L-NAME induced hypertension. However, in all cases, we did not observe any significative variation of heart rate. For biochemical parameters, we did not find any effect, excepted a significant increase of phosphoremia at 400 mg/kg bw and after L-NAME administration (highly significant). Our results confirm literature data and corroborate traditional uses of Z. officinale sold in Ouagadougou markets. They suggest that antihypertensive effect of AEZO is mainly supported by vascular physiology components.

scholarly journals Effect of Aqueous Extract of Senna occidentalis Leaves on Haematological and Liver Biochemical Parameters in Wistar Rats

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
OWOLARAFE TAJUDEEN ALOWONLE
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Weight Ratio ◽  
Haematological Parameters ◽  
Histological Evaluation ◽  
Albino Rats ◽  
Body Weight Ratio ◽  
Glutamyl Transferase

This study evaluated the effect of aqueous extract of Senna occindentalis leaves on some biochemical parameters in Wistar rats. Twenty albino rats equally divided into four experimental groups were used. One group served as control and received the carrier solvent treatment. Three test groups were treated with S. occidentalis extract at 500, 1000 and 1500 mg/kg body weight respectively. The experiment lasted for 14 days after which the rats were sacrificed and blood collected for biochemical and haematological evaluation. Liver-body weight ratio was computed and liver histoarchitecture was investigated. The results showed that all haematological parameters were significantly (P<0.05) affected except the mean corpuscular haemoglobin concentration and mean corpuscular volume. There were also significant (P<0.05) alterations in the activities of gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase, as well as the levels of total protein, albumin and globulin in the serum. No significant (P>0.05) alterations were observed in the computed liver-body weight ratio but marked alterations in histoarchitecture of the liver cells were present. These alterations in the haematological parameters, liver function enzymes and histological evaluation suggest a selective toxicity of the extract on the animals.

Ameliorative potential of Sterculia tragacantha aqueous extract on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats

2020 ◽  
Vol 51 (1) ◽  
pp. 103-113
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Precious Ekong Essien ◽  
Sunday Amos Onikanni ◽  
Oluwafemi Adeleke Ojo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Diabetic Rats

Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

2018 ◽  
Vol 8 (4) ◽  
pp. 061-065
Author(s):  
F.N OGUWIKE ◽  
◽  
I.C IFEDI ◽  
C.N DIM ◽  
C.P IGWEDIBIA ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Male And Female

scholarly journals Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

2021 ◽  
Vol 41 (02) ◽  
pp. 138-144
Author(s):  
Lucas Petitemberte de Souza ◽  
Henrique Sarubbi Fillmann ◽  
Sandielly Rebeca Benitez da Fonseca ◽  
Marilda da Silva Brasil ◽  
Norma Anair Possa Marroni ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Experimental Colitis ◽  
Anal Pressure ◽  
Antioxidant Power ◽  
Significance Level ◽  
Sphincter Anal

AbstractDue to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p < 0.05. The screening indicated the presence of flavonoids, saponins and tannins in the extract, with high levels of phenolic compounds and tannins, and was related to high antioxidant capacity. In the histological analysis, the CL group presented loss of the crypts, edema and inflammatory infiltrate. The use of C. laurifolia extract restructured the crypts, decreased edema and increased sphincter anal pressure, with a decrease in LPO, SOD, and an increase in GSH. It is suggested that the use of C. laurifolia extract reduces OS due to its antioxidant power conferred by the phenolic compounds present in the extract.

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