scholarly journals Evaluation of Hepatoprotective Activity of Caralluma europaea Stem Extract against CCl4-Induced Hepatic Damage in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hayat Ouassou ◽  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hassane Mekhfi ◽  
Abderrahim Ziyyat ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Hepatoprotective Effect ◽  
Low Density

The present study aims to evaluate the hepatoprotective activity of stem aqueous extract of Caralluma europaea (AECe) on carbon tetrachloride- (CCl4-) induced hepatic damage in Wistar rats. The animals were daily treated with the aqueous extract of C. europaea at a dose of 250 mg/kg body weight for 14 days. CCl4 was injected (1 ml/kg, i.p.) two times, on the 7th and 14th days. At the end of the experimental period, all rats were anesthetized to collect blood for the assessment of biochemical parameters and then sacrificed to collect the liver for weighing. Hepatotoxicity was evaluated by measuring the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin (total and direct), malondialdehyde (MDA), total protein (TP), triglycerides (TG), total cholesterol, very low-density lipoprotein (VLDL-c ), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), urea, creatinine, and uric acid. Based on the results obtained in this study, the administration of C. europaea before exposure to the administration of CCl4 conferred favorable hepatoprotective effect in rats. The treatment with AECe (250 mg/kg) exhibits a significant hepatoprotective effect by ameliorating CCl4-induced alterations of these biochemical parameters. Hence, C. europaea could be a potential medicinal herb that can be used in the future to prevent liver intoxication.

scholarly journals Evaluation of the Effects of Aqueous Fruit Extract of Tamarindus indica on Body Weight, Lipid Profile, Some Electrolytes and Urea of Wistar Rats

2021 ◽  
pp. 444-451
Author(s):  
I. P. Ekpe ◽  
Dennis Amaechi ◽  
B. N. Yisa ◽  
O. G. Osarhiemen
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Healthy Weight ◽  
Group I ◽  
Significant Difference

Objectives: The objectives of this research is to evaluate the effects of aqueous extract of T. indica on  weight, lipid parameters, some electrolytes and urea of Wistar rats Design & Methods: Twenty-five Male  Adult  rats were grouped into four  consisting of six rats each. Group I served as control group, group II was administered 100mg/kg of the Aqueous extract, group III was administered 150mg/kg of the Aqueous extract, and Group IV was administered 200mg/kg of the Aqueous extract. The administration took place for seven days, and on the eight day, The Animals were sacrificed. The blood samples was collected via cardiac puncture and used for analysis using a visible spectrophotometer. Results: From the result, there was no significant difference (p<0.05) in body weight of Wistar rats. In the Test Groups; Serum cholesterol, low density lipoprotein (LDL), High density lipoprotein (HDL), Very Low-density Lipoprotein and Triglycerides revealed a significant increase (p<0.05) compared to Group 1 which is the control Group but had a significant decrease (p<0.05) compared within test groups. For electrolytes concentrations, potassium, Sodium, Chloride and Urea concentrations was significant at p<0.05. Conclusion: the results above ,T. indica extract may help to maintain healthy weight, may have hypolipidemic properties, may help in body homeostatic and fluid balance and may also prevent renal damages. 

scholarly journals Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Efosa Godwin Ewere ◽  
Ngozi Paulinus Okolie ◽  
Erhunmwunsee Dalton Avan ◽  
Patience Edet Umoh
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Sodium Arsenite ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Stem Bark ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Irvingia Gabonensis

Abstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Methods Fifty five Wistar rats weighing between 100 g and 179 g were distributed into eleven groups (n=5). Group 1 (control) received feed and water ad libitum. Group 2 received SA at a dose of 4.1 mg/kg body weight (kgbw) for 14 days. Groups 3–11 were treated with the extracts with or without SA. Treatment was done by oral intubation for 14 days. Serum concentrations of total cholesterol (TC), triacylglycerol (TAG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), total lipids (TL) and atherogenic index of plasma (AIP) were used to determine the lipid profile effects of the extracts. Results Exposure to SA caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Post-treatment and simultaneous treatment with ELEIG and ESEIG mitigated the effects of SA. In addition, ELEIG alone at various doses produced results comparable with control values. However, ESEIG alone caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Conclusion These results show that ELEIG and ESEIG ameliorate SA-induced lipid profile disturbances in Wistar rats. However, long-term administration of ESEIG alone may be discouraged.

scholarly journals Comparative study between the prophylactics Effects of aqueous extract of Black Currant (Vitis vinferia.L) and vitamin E on some biological parameters related with heart diseases in oxidative Stressed rats

2008 ◽  
Vol 32 (2) ◽  
pp. 227-252
Author(s):  
Abdul-Katum A. H.
Keyword(s):  
Drinking Water ◽  
Platelet Count ◽  
Vitamin E ◽  
Prothrombin Time ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Black Currant ◽  
Oral Intubation

This study was designed to investigate the prophylactic effect of aqueousextract of black currant concentrate on some biological markers related withheart disease in male rat treated H2O2. It also aimed at comparing theprophylactic effect of black currant concentrate to that of vit E.Forty adult male rats were divided randomly into equal groups (tenrat/group) & were treated as follows for 42 days. Rats in the first group (G І)were received normal water with oral intubation of sun flower oil 1ml /rat andconsider as control group. Animals of the second group (G Π) were received0.5% H2O2 in drinking water, while rats of the third group (G Ш) were received0.5% H2O2 in drinking water with oral intubation of vit E 400 I.U/Kg.B.Wdiluting in sun flower oil for each rat daily .While animals in the fourth group (GІV) were intubated daily 60mg/kg body weight of aqueous extract of blackcurrant concentrate plus 0.5% H2O2 in drinking water.Fasting blood samples were collected at 0, 21, and 42 days of experimentto study the following parameters:A - Platelet count (PC) and prothrombin time (PT).B- Serum concentration of total cholesterol TC, triacylglycerol TAG, Highdensity lipoprotein-cholesterol HDL-C, Low density lipoprotein-cholesterolLDL-C and Very low density lipoprotein- cholesterol VLDL-C of each groupwere measured. These parameters were regarded as biomarkers ofatherosclerosis and coronary heart disease (CHD). Furthermore section of heart& aorta were assessed for histopathogical studies.The result revealed that administration of 0.5% H2O2 in drinking water for sixweeks (42days) caused significant increase (p<0.05) in platelet count & in serumTC,TAG,LDL-C, and VLDL-C concentration with significant decrease(p<0.05)in prothrombin time and HDL-C concentration as compared to other groups, onother hand oral intubation of vitamin E or aqueous extract of black currantconcentrate in addition to H2O2 (groups Ш and ІV respectively) decreased theserum concentration of TC, TAG, LDL-C, VLDL-C, and platelet countIraqi Journal of Veterinary Medicine Vol. 32, No. 2, 2008228

scholarly journals The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium Occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Male Wistar Rats

2021 ◽  
Author(s):  
Folasade O. AJAO ◽  
Michael A. Olamoyegun ◽  
Marcus O. Iyedupe
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Anacardium Occidentale ◽  
Low Density ◽  
Reference Drug ◽  
Antioxidative Effects ◽  
Group 2

Abstract Background: This research work investigated the antidiabetic, anti-hyperlipidemic, and antioxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin (STZ)-induced diabetic Wistar rats. Methods: Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8 rats each. Group 1 served as the control; Group 2-5 were induced with diabetes with a single dose of 50mg/kg bw of streptozotocin intraperitoneally. After diabetes induction, Group 2 served as the STZ-only group, Groups 3 and 4 were administered 100mg/kg bw and 200mg/kg bw p.o Anacardium occidentale nut extract, respectively, while Group 5 was administered 2mg/kg bw of glimepiride as a reference drug for a period of 4 weeks. Food and water intake were monitored daily, body weight, and blood glucose levels weekly throughout the experiment. On day 29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Results: Administration of the nut extract significantly (p<0.05) increased the food intake and body weight of diabetic treated rats, fasting blood glucose level and oral glucose tolerance test (OGTT) decreased significantly (p<0.05) in treated rats. On lipid profile, administration of nut extract significantly decreased (p<0.05) triglyceride, low-density lipoprotein, total cholesterol, and very-low-density lipoprotein concentrations while it significantly increases (p<0.05) the high-density lipoprotein. Anacardium occidentale nut extract caused significantly (p<0.05) increases in SOD, GPx, GSH, and CAT levels with a decrease MDA level in diabetic treated rats. Markers of liver and kidney functions were also improved in diabetic treated rats.Conclusion: Treatment with Anacardium occidentale methanolic nut extract has hypoglycemic, hypolipidemic, and hepato-protective effects in diabetic rats. It also alleviates oxidative stress activity and restoration of markers of kidney function, and may be useful as alternative therapy in the management of diabetes and its related complications.

scholarly journals Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

2015 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Mohamed Aboubakr ◽  
Abdelazem Mohamed Abdelazem
Keyword(s):  
Aqueous Extract ◽  
Histopathological Examination ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Hepatoprotective Activity ◽  
Lipoprotein Cholesterol ◽  
Albino Rats ◽  
Aqueous Extracts

<p>The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 &amp; 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.</p>

Effect of Prunus Dulcis & Álpha-Tocopherol in Ethanol Induced Dyslipidemia In Wistar Rats

2020 ◽  
Vol 13 (4) ◽  
pp. 1619-1624
Author(s):  
Samuel Sundar Doss ◽  
J. Vijayakumar ◽  
E. Sukumar ◽  
K. Rekha
Keyword(s):  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Prunus Dulcis ◽  
Alpha Tocopherol ◽  
Control Group ◽  
P Value ◽  
Low Density ◽  
Ethanol Group ◽  
Beneficial Effects

The study is aimed at assessing the effect of Prunus dulcis and alpha-tocopherol treatment against ethanol induced dyslipidemia in Wistar rats. 30 albino Wistar rats were selected based on the selection criteria and equally distributed into 5 groups – Control, ethanol, Prunus dulcis, alpha-tocopherol and combination of alpha-tocopherol + Prunus dulcis treated for 40 days. After the treatment for 40 days, all the animals were euthanized and a retro-orbital puncture was made to collect the blood samples for biochemical investigations. Obtained results were statistically analysed using ANOVA. Compared to ethanol group alpha tocopherol, Prunus dulcis and alpha tocopherol + Prunus dulcis treatment significantly decreased total cholesterol and triglycerides levels with p value <0.001. High density lipoprotein (66.31%) levels in the ethanol group were decreased compared to the control group and were significantly increased in other groups. Low density lipoprotein and Very low density lipoprotein levels were higher in the ethanol group compared with the control group and were significantly reduced in other groups with p value <0.001. Results suggest that ethanol has an ill effect on the lipid profile. Treatment with Prunus dulcius and alpha-tocopherol both solely or in combination has produced beneficial effects against dyslipidemia.

scholarly journals A study on correlation of lipid profile with body mass index in young adults (18-20 years)

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 102-107
Author(s):  
Gurupavan Kumar Ganta ◽  
Divya D ◽  
Kedari G S R
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Young Adults ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Low Density

Overweight and obesity in youth is a worldwide public health problem. Predisposition to obesity starts during the first or second decade of life. Overweight and obesity in adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidaemia, hypertension and type 2 diabetes mellitus. Our study was done to find the relation between body mass index (BMI) and lipid profile in young adults (18-20 years) and for the correlation between the various parameters. 150 young adults between 18-20 years of age, who gave written voluntary consent were included in the study. BMI was calculated after measuring height and weight along with fasting blood samples for estimation of blood glucose and lipid profile [Total cholesterol, High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and triacylglycerol (TGL)] were measured. The data collected was analysed using Statistical package for the social sciences (SPSS) statistics software version 20. A linear correlation regression analysis was done to know the correlation between the anthropometric measurements and biochemical parameters. ANOVA test was performed to know the significance and a p value of < 0.01 was taken as significant. All the biochemical parameters showed a positive correlation with BMI. Total cholesterol had the highest positive correlation with BMI. There was a prevalence of 39.3% overweight/obesity as per BMI cut-off. Individuals who were in the obese category had a higher prevalence of abnormal lipid profile especially total cholesterol. Stress and lack of physical activity have a detrimental effect on health and are a major risk factor for development of obesity. 90% of the students in this study did not have any regular physical activity. Educating the students about effects of obesity and dyslipidaemia on quality of health can help in bringing life style modifications which can help them in the long run.

scholarly journals The Hypolipidemic Effect of Aqueous Extract of Hibiscus sabdariffa on Paracetamol-induced Hepatotoxicity in Albino Wistar Rats

2020 ◽  
pp. 54-60
Author(s):  
E. B. Umoren ◽  
J. F. Ekpenyong ◽  
O. E. Oyama ◽  
A. O. Obembe
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
The Body ◽  
Control Group ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Hibiscus Sabdariffa

Aim of the Study: This study was undertaken to ascertain if Hibiscus sabdariffa extract can affect the lipid profile (Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL)) levels in a paracetamol- induced hepatotoxicity using albino Wistar rat as a model. Materials and Methods: Thirty (30) rats used for this study were divided into three groups. Group A (n=10) served as control. Group B (n=10) was administered paracetamol only at a dose of 750 mg/kg body weight. Group C (n=10) was administered paracetamol (dose 750 mg/kg body weight) and aqueous extract of H. sabdariffa (dose 10 ml/kg body weight) of the animal for 3 weeks. All animals were allowed free access to clean drinking water and normal rat chow. Results: Results of the study revealed that TC was significantly lower (p<0.05) in the paracetamol + H. sabdariffa-treated group as compared to paracetamol-treated group and control respectively. Similar trend was observed with TG, VLDL-c, LDL-c and HDL-c. However, the decrease in HDL-c was not statistically significant when compared to control. Conclusion: The presence of bioactive constituents vis; anthocyanins, flavonoids, polyvenols and free radical scavenging properties in H. sabdariffa enabled a hypolipidemic effect on the animals by lowering the levels of serum TG, VLDL-c, LDL-c despite challenge on the liver. However, it was unable to produce significant effect on HDL concentration -very important cholesterol required in high level to maintain homeostasis inside the body. This may be due to the challenge on the liver as a result of the paracetamol abuse.

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