Dietary Combination of Conjugated Linoleic Acid (CLA) and Pine Nut Oil Prevents CLA-Induced Fatty Liver in Mice

2008 ◽  
Vol 56 (17) ◽  
pp. 8148-8158 ◽  
Author(s):  
Alessandra Ferramosca ◽  
Viviana Savy ◽  
Laura Conte ◽  
Vincenzo Zara
Keyword(s):  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Pine Nut ◽  
Pine Nut Oil

scholarly journals Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice

2008 ◽  
Vol 101 (10) ◽  
pp. 1558 ◽  
Author(s):  
Daichi Oikawa ◽  
Shoichiro Tsuyama ◽  
Yoriko Akimoto ◽  
Yurika Mizobe ◽  
Mitsuhiro Furuse
Keyword(s):  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid

scholarly journals Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver

2007 ◽  
Vol 97 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Reuven Rasooly ◽  
Darshan S. Kelley ◽  
Jeff Greg ◽  
Bruce E. Mackey
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Fatty Acid Oxidation ◽  
Fatty Acid Synthase ◽  
Detoxification Enzymes ◽  
Acid Oxidation ◽  
Drug Detoxification ◽  
Hepatic Genes

Mice fed diets containing trans 10, cis 12 (t10, c12)-conjugated linoleic acid (CLA) develop fatty livers and the role of hepatic fatty acid oxidation enzymes in this development is not well defined. We examined the effects of dietary cis 9, trans 11-CLA (c9, t11-CLA) and t10, c12-CLA on the expression of hepatic genes for fatty acid metabolism. Female mice, 8 weeks old, (six animals per group) were fed either a control diet or diets supplemented with 0·5 % c9, t11- or t10, c12-CLA for 8 weeks. DNA microarray analysis showed that t10, c12-CLA increased the expression of 278 hepatic genes and decreased those of 121 genes (>2-fold); c9, t11-CLA increased expression of twenty-two genes and decreased those of nine. Real-time PCR confirmed that t10, c12-CLA reduced by the expression of fatty acid oxidation genes including flavin monooxygenase (FMO)-3 95 %, cytochrome P450 (cyt P450) 69 %, carnitine palmitoyl transferase 1a 77 %, acetyl CoA oxidase (ACOX) 50 % and PPARα 65 %; it increased the expression of fatty acid synthase by 3·5-fold (P < 0·05 for all genes, except ACOX P = 0·08). It also reduced the enzymatic activity of hepatic microsomal FMO by 40 % and the FMO3 specific protein by 67 %. c9, t11-CLA reduced FMO3 and cyt P450 expression by 61 % (P = 0·001) and 38 % (P = 0·06) and increased steoryl CoA desaturase transcription by 5·9-fold (P = 0·07). Both decreased fatty acid oxidation and increased fatty acid synthesis seem to contribute to the CLA-induced fatty liver. Since FMO and cyt P450 are also involved in drug detoxification, suppression of the transcription of these genes by CLA may have other health consequences besides development of fatty liver.

scholarly journals A high dose of conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0214903 ◽  
Author(s):  
Kun Pang ◽  
Zhongke Zhu ◽  
Songbo Zhu ◽  
Liqiang Han
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
High Dose

scholarly journals Effects of conjugated linoleic acid on oxidative stress in rats with sucrose-induced non-alcoholic fatty liver disease

2012 ◽  
Vol 4 (1) ◽  
pp. 219-225 ◽  
Author(s):  
Yohevet Romero-Sarmiento ◽  
Ida Soto-Rodríguez ◽  
Agustín Arzaba-Villalba ◽  
Hugo Sergio García ◽  
Alfonso Alexander-Aguilera
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals An high dose of a conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice

2019 ◽  
Author(s):  
Kun Pang ◽  
Song bo Zhu ◽  
Liqiang Han
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Liver Weight ◽  
Blood Parameters ◽  
High Dose ◽  
Lactation Performance ◽  
Insulin Tolerance

AbstractThis study aimed to evaluate the effect of a high dose of conjugated linoleic acid (CLA) on lactating mice. In experiment one, KUNMING mice were separated into four groups (n = 6 per group); the control (CON) group received 3.0% linoleic acid oil (LA), the L-CLA group received 1.0% LA and 2.0% CLA mixture, the M-CLA group received 2.0% LA and 1.0% CLA mixture, and the H-CLA group received 3.0% CLA mixture. Feeding proceeded from day 4 to day 10 during lactation. In experiment two, the CON group received 2.0% LA and the H-CLA group received 2.0% CLA. Blood parameters were analysed for all groups, and insulin tolerance tests (ITTs) were conducted. CLA treatment did not affect the dam weight, but it significantly decreased the food intake of dams. Furthermore, CLA decreased the weight of pups, which was attributed to lower milk fat. H-CLA group mice displayed increased liver weight and liver triglyceride content, as well as a higher TG content and γ-GT activity in blood. Moreover, a high dose of CLA resulted in insulin resistance, possibly affecting the RBC and HCB of blood. In conclusion, lactating mice receiving a high dose of CLA led to fatty liver, insulin resistance, and impaired lactation performance.

Trans–trans Conjugated Linoleic Acid Enriched Soybean Oil Reduces Fatty Liver and Lowers Serum Cholesterol in Obese Zucker Rats

Lipids ◽  
2011 ◽  
Vol 46 (10) ◽  
pp. 961-968 ◽  
Author(s):  
William Gilbert ◽  
Vidya Gadang ◽  
Andrew Proctor ◽  
Vishal Jain ◽  
Latha Devareddy
Keyword(s):  
Linoleic Acid ◽  
Fatty Liver ◽  
Soybean Oil ◽  
Conjugated Linoleic Acid ◽  
Serum Cholesterol ◽  
Zucker Rats ◽  
Obese Zucker Rats ◽  
Trans Conjugated Linoleic Acid

γ-Linolenic acid prevents conjugated linoleic Acid–Induced fatty liver in mice

Nutrition ◽  
2004 ◽  
Vol 20 (4) ◽  
pp. 390-393 ◽  
Author(s):  
Tomonori Nakanishi ◽  
Daichi Oikawa ◽  
Tomoyuki Koutoku ◽  
Hachidai Hirakawa ◽  
Yasuhiro Kido ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Linolenic Acid

Conjugated Linoleic Acid-Induced Fatty Liver Can Be Attenuated by Combination with Docosahexaenoic Acid in C57BL/6N Mice

2005 ◽  
Vol 53 (24) ◽  
pp. 9629-9633 ◽  
Author(s):  
Teruyoshi Yanagita ◽  
Yu-Ming Wang ◽  
Koji Nagao ◽  
Yoko Ujino ◽  
Nao Inoue
Keyword(s):  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid
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