scholarly journals An high dose of a conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice

2019 ◽  
Author(s):  
Kun Pang ◽  
Song bo Zhu ◽  
Liqiang Han
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Liver Weight ◽  
Blood Parameters ◽  
High Dose ◽  
Lactation Performance ◽  
Insulin Tolerance

AbstractThis study aimed to evaluate the effect of a high dose of conjugated linoleic acid (CLA) on lactating mice. In experiment one, KUNMING mice were separated into four groups (n = 6 per group); the control (CON) group received 3.0% linoleic acid oil (LA), the L-CLA group received 1.0% LA and 2.0% CLA mixture, the M-CLA group received 2.0% LA and 1.0% CLA mixture, and the H-CLA group received 3.0% CLA mixture. Feeding proceeded from day 4 to day 10 during lactation. In experiment two, the CON group received 2.0% LA and the H-CLA group received 2.0% CLA. Blood parameters were analysed for all groups, and insulin tolerance tests (ITTs) were conducted. CLA treatment did not affect the dam weight, but it significantly decreased the food intake of dams. Furthermore, CLA decreased the weight of pups, which was attributed to lower milk fat. H-CLA group mice displayed increased liver weight and liver triglyceride content, as well as a higher TG content and γ-GT activity in blood. Moreover, a high dose of CLA resulted in insulin resistance, possibly affecting the RBC and HCB of blood. In conclusion, lactating mice receiving a high dose of CLA led to fatty liver, insulin resistance, and impaired lactation performance.

scholarly journals A high dose of conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0214903 ◽  
Author(s):  
Kun Pang ◽  
Zhongke Zhu ◽  
Songbo Zhu ◽  
Liqiang Han
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Fatty Liver ◽  
Conjugated Linoleic Acid ◽  
High Dose

Diet containing dehulled adlay ameliorates hepatic steatosis, inflammation and insulin resistance in rats with non-alcoholic fatty liver disease

2021 ◽  
pp. 1-25
Author(s):  
Wan-Ju Yeh ◽  
Jung Ko ◽  
Wei-Yi Cheng ◽  
Hsin-Yi Yang
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Weight ◽  
Vital Role ◽  
High Dose ◽  
Alcoholic Fatty Liver ◽  
Protein Levels ◽  
Alcoholic Fatty Liver Disease

Abstract Dietary modification plays a vital role in the treatment of non-alcoholic liver diseases. We investigated the effects of the consumption of different amount of dehulled adlay, which has hypolipidemic and anti-inflammatory properties, on non-alcoholic fatty liver disease (NAFLD). We fed rats a high-fat-high-fructose liquid diet for 16 weeks to induce NAFLD. The rats were divided into three groups fed the NAFLD diet only (NN) or a diet containing 44.9 g/L or 89.8 g/L of dehulled adlay (group NA and NB, respectively). After 8 weeks, the NA & NB group had lower C-reactive protein levels and improvement in insulin resistance. In addition, the NB group had lower liver weight and hepatic triglyceride and cholesterol concentrations than did the NN group. Compared with the NN group, the high-dose NB group had improved steatosis, lower hepatic TNF-α, IL-1β and IL-6 levels, and lower adipose leptin levels. Our results suggest that a diet containing dehulled adlay can ameliorate NAFLD progression by decreasing of insulin resistance, steatosis and inflammation.

scholarly journals Effects of dietary sunflower seeds on lactation performance and conjugated linoleic acid content of milk

2005 ◽  
Vol 85 (1) ◽  
pp. 75-83 ◽  
Author(s):  
M. L. He ◽  
P. S. Mir ◽  
K. A. Beauchemin ◽  
M. Ivan ◽  
Z. Mir
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Milk Production ◽  
Milk Fat ◽  
Sunflower Seed ◽  
Body Condition Score ◽  
Linoleic Acid Content ◽  
Cow Milk ◽  
Lactation Performance ◽  
Condition Score

The conjugated linoleic acid (CLA) concentration in milk and the lactation performance of cows fed either a control (CON) or a sunflower seed [SS; 7% of dietary dry matter (DM)] containing diet were compared in a 12-wk lactation trial, starting from week 3 after calving, with 17 multiparous and 8 primiparous cows. The CON and SS diets were isonitrogenous and provided 4 and 6% crude fat in the total mixed rations and were fed to 13 and 12 cows, respectively. Daily DM intake (DMI ), milk production and weekly body weights were recorded. Milk samples collected weekly at four consecutive milkings were individually analyzed for fat, protein and lactose content, and fatty acid composition. The DMI and milk production of the cows fed t he CON and SS diets were 20.5 ± 0.80 and 20.2 ± 0.80 kg d-1 (P > 0.05) and 38.2 ± 1.71 and 38.2 ± 1.71 kg d-1 (P > 0.05), respectively. No differences due to diet were observed for cow body weight, body condition score, or for content and yield of milk fat, protein and lactose. The CLA cis-9, trans-11 concentration in milk from cows fed the CON and SS diets was 3.9 and 7.9 mg g-1 fatty acids (P < 0.01), respectively. The average CLA cis-9, trans-11 yield in milk from cows fed CON and SS diets was 5.1 ± 0.07 and 10.9 ± 0.07 g d-1, respectively, or 114% greater (P < 0.05) for cows fed the SS diet. The study indicates that sunflower seed inclusion at 7% of dietary DM to dairy cows increases the CLA concentration and yield in milk, without affecting DMI, milk production or composition. Key words: Conjugated linoleic acids, cow, milk, sunflower seed

scholarly journals High Dose of A Conjugated Linoleic Acid Mixture Increases Insulin Resistance in Rats Fed Either A Low Fat or A High Fat Diet

2018 ◽  
Vol 126 (06) ◽  
pp. 379-386 ◽  
Author(s):  
Priscila Bezan ◽  
Héric Holland ◽  
Gabriela de Castro ◽  
João Cardoso ◽  
Paula Ovidio ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Soybean Oil ◽  
Conjugated Linoleic Acid ◽  
Fat Mass ◽  
High Fat Diet ◽  
High Dose ◽  
High Fat ◽  
Low Fat ◽  
Animal Fat

AbstractObesity and related diseases are becoming more prevalent. Conjugated linoleic acid (CLA) might be a useful coadjutant treatment helping to decrease fat mass. However, the precise impact of CLA is unclear because the decreased body fat mass is followed by an increase in insulin resistance. This study aimed to evaluate some of the consequences of a high dose of CLA in rats fed a normal low fat or a high fat diet for 30 days. Male Wistar rats were separated into 4 groups (each n = 10): Control group receiving 7% fat (soybean oil); CLA group receiving 4% soybean oil and 3% CLA mixture; animal fat (AF) group, receiving 45% fat (lard); and animal fat plus CLA (AF+CLA) group, receiving 42% lard and 3% CLA mixture. The CLA mixture contained 39.32 mole% c9,t11-CLA and 40.50 mole% t10,c12-CLA. After 30 days, both CLA groups (CLA and AF+CLA groups) developed insulin resistance, with an increase in glucose in the fasting state and in an insulin tolerance test. The CLA group had increased liver weight and percentage of saturated fatty acids in liver and adipose tissue. Feeding the high fat diet resulted in increased hepatic triacylglycerol accumulation and this was exacerbated by dietary CLA. It is concluded that a high dose of CLA mixture increases insulin resistance and exacerbates hepatic steatosis when combined with a high fat diet.

scholarly journals Influence of Dietary Fish Oil on Conjugated Linoleic Acid and Other Fatty Acids in Milk Fat from Lactating Dairy Cows

2000 ◽  
Vol 83 (11) ◽  
pp. 2620-2628 ◽  
Author(s):  
D.C. Donovan ◽  
D.J. Schingoethe ◽  
R.J. Baer ◽  
J. Ryali ◽  
A.R. Hippen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Fish Oil ◽  
Dairy Cows ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Lactating Dairy Cows ◽  
Dietary Fish

scholarly journals A Supplement Containing Trans-10, Cis-12 Conjugated Linoleic Acid Reduces Milk Fat Yield but Does Not Alter Organ Weight or Body Fat Deposition in Lactating Ewes

2010 ◽  
Vol 140 (11) ◽  
pp. 1949-1955 ◽  
Author(s):  
Liam A. Sinclair ◽  
Weerasinghe M. P. B. Weerasinghe ◽  
Robert G. Wilkinson ◽  
Michael J. de Veth ◽  
Dale E. Bauman
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Milk Fat ◽  
Fat Deposition ◽  
Organ Weight ◽  
Fat Yield

scholarly journals Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through NFκB-dependent Cytokine Production

2005 ◽  
Vol 280 (46) ◽  
pp. 38445-38456 ◽  
Author(s):  
Soonkyu Chung ◽  
J. Mark Brown ◽  
J. Nathan Provo ◽  
Robin Hopkins ◽  
Michael K. McIntosh
Keyword(s):  
Insulin Resistance ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cytokine Production ◽  
Human Adipocyte
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