Protective Effects of Bilberry (Vaccinium myrtillusL.) Extract on Restraint Stress-Induced Liver Damage in Mice

2008 ◽  
Vol 56 (17) ◽  
pp. 7803-7807 ◽  
Author(s):  
Li Bao ◽  
Xin-Sheng Yao ◽  
Chin-Chin Yau ◽  
Daniel Tsi ◽  
Chew-Sern Chia ◽  
...  
Keyword(s):  
Liver Damage ◽  
Restraint Stress ◽  
Protective Effects

scholarly journals Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hao-Jie Pu ◽  
Yun-Feng Cao ◽  
Rong-Rong He ◽  
Zhi-Long Zhao ◽  
Jin-Hui Song ◽  
...  
Keyword(s):  
Free Radicals ◽  
Liver Damage ◽  
Restraint Stress ◽  
Liver Cells ◽  
Protective Effects ◽  
Male Mice ◽  
Stress Effects ◽  
Restraint Tube ◽  
Hepatoprotective Effects ◽  
The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

scholarly journals Protective effects of Erythronium japonicum and Corylopsis coreana Uyeki extracts against 1,3-dichloro-2-propanol-induced hepatotoxicity in rats

2020 ◽  
Vol 50 (1) ◽  
Author(s):  
Seunghyun Kim ◽  
Hee-Ock Boo ◽  
Taeho Ahn ◽  
Chun-Sik Bae
Keyword(s):  
Liver Damage ◽  
Enzyme Activities ◽  
Oxygen Species ◽  
Protective Effects ◽  
Catalytic Activities ◽  
Anti Oxidant ◽  
Cyp2e1 Activity ◽  
Pre Treatment ◽  
Histopathological Studies ◽  
Erythronium Japonicum

AbstractErythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

scholarly journals Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats

2019 ◽  
Vol 110 ◽  
pp. 742-747 ◽  
Author(s):  
Zuleyha Erisgin ◽  
Melahat Atasever ◽  
Kadir Cetinkaya ◽  
Saadet Özen Akarca Dizakar ◽  
Suna Omeroglu ◽  
...  
Keyword(s):  
Liver Damage ◽  
Nigella Sativa ◽  
Protective Effects ◽  
Nigella Sativa Oil

scholarly journals Protective Effects of Colomast®, a New Formulation of Adelmidrol and Sodium Hyaluronate, in a Mouse Model of Acute Restraint Stress

2020 ◽  
Vol 21 (21) ◽  
pp. 8136
Author(s):  
Ramona D’Amico ◽  
Rosalba Siracusa ◽  
Roberta Fusco ◽  
Marika Cordaro ◽  
Tiziana Genovese ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Cell Activation ◽  
Sodium Hyaluronate ◽  
Neutrophil Infiltration ◽  
Mast Cell Activation ◽  
Adhesive Tape ◽  
Protective Effects ◽  
Depression And Anxiety ◽  
Acute Restraint Stress ◽  
Apoptosis Pathways

Stress is generally defined as a homeostatic disruption from actual or implied threats and alters the homeostatic balance of different body organs, such as gastrointestinal function and the hypothalamic-pituitary-adrenal axis (HPA), inducing the release of glucocorticoid hormones. Stress is also known to be a risk factor for the development of depression and anxiety. However, until today there are no suitable therapies for treating of stress. The aim of this study was to explore the protective effect of Colomast®, a new preparation containing Adelmidrol, an enhancer of physiological of palmitoylethanolamide (PEA), and sodium hyaluronate in an animal model of immobilization stress. Acute restraint stress (ARS) was induced in mice by fixation for 2 h of the four extremities with an adhesive tape and Colomast® (20 mg/kg) was administered by oral gavage 30 min before the immobilization. Colomast® pre-treatment was able to decrease histopathological changes in the gastrointestinal tract, cytokines expression, neutrophil infiltration, mast cell activation, oxidative stress, as well as modulate nuclear factor NF-kB and apoptosis pathways after ARS induction. Moreover, Colomast® was able to restore tight junction in both ileum and hippocampus and cortex. Additionally, we demonstrated that Colomast® ameliorated depression and anxiety-related behaviours, and modulate inflammatory and apoptosis pathways also in brain after ARS induction. In conclusion, our results suggest Colomast® to be a potential approach to ARS.

scholarly journals Evaluation of Humic Acid as an Aflatoxin Binder in Broiler Chickens

2017 ◽  
Vol 17 (1) ◽  
pp. 241-255 ◽  
Author(s):  
Rana Yaser Arafat ◽  
Sohail Hassan Khan ◽  
Keyword(s):  
Body Weight ◽  
Humic Acid ◽  
Adverse Effects ◽  
Liver Damage ◽  
Broiler Chickens ◽  
Management Practices ◽  
Basal Diet ◽  
Aflatoxin Contamination ◽  
Protective Effects ◽  
Serum Biochemical

AbstractThe efficacy of humic acid (HA) as an aflatoxin (AF) binder in broiler chickens exposed to aflatoxin- contaminated feed from 1 to 42 days of age was assessed. A total of 200 birds were assigned to 20 pens, with 10 birds per pen. The following treatments (T) were applied: T1: basal diet (B); T2: B + AFB1(100 μg/kg); T3: B + AFB1(100 μg/kg) + HA (0.1%); T4: B +AFB1 (100 μg/kg) + HA (0.2%); T5: B + AFB1 (100 μg/kg) + HA (0.3%). Each treatment consisted of 4 replicates. Oxihumate was effective in diminishing the adverse effects caused by aflatoxin on body weight (BW) of broilers (P<0.05). Humic acid also showed protective effects against liver damage and some of the hematological and serum biochemical changes associated with aflatoxin toxicity (P<0.05). The supplementation of HA also enhanced the humoral immunity by counteracting the aflatoxin contamination. Results indicated that HA could alleviate some of the toxic effects of aflatoxin in growing broilers. Humic acid (0.1 to 0.3%) might, therefore, prove to be beneficial in the management of aflatoxin-contaminated feedstuffs for poultry when used in combination with other mycotoxin management practices.

The Protective Effects of Silymarin on Thioacetamide-Induced Liver Damage: Measurement of miR-122, miR-192, and miR-194 Levels

2019 ◽  
Vol 191 (2) ◽  
pp. 528-539 ◽  
Author(s):  
Ozgun Teksoy ◽  
Varol Sahinturk ◽  
Mustafa Cengiz ◽  
Behcet İnal ◽  
Adnan Ayhancı
Keyword(s):  
Liver Damage ◽  
Protective Effects

Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats

2009 ◽  
Vol 65 (4) ◽  
pp. 339-344 ◽  
Author(s):  
S. Oktar ◽  
Z. Yönden ◽  
M. Aydin ◽  
S. Ilhan ◽  
E. Alçin ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Liver Damage ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects

Theacrine, a Purine Alkaloid Obtained fromCamellia assamicavar.kucha, Attenuates Restraint Stress-Provoked Liver Damage in Mice

2013 ◽  
Vol 61 (26) ◽  
pp. 6328-6335 ◽  
Author(s):  
Wei-Xi Li ◽  
Yi-Fang Li ◽  
Yu-Jia Zhai ◽  
Wei-Min Chen ◽  
Hiroshi Kurihara ◽  
...  
Keyword(s):  
Liver Damage ◽  
Restraint Stress ◽  
Purine Alkaloid

The Hepatoprotective Effects of Taiwan Folk Medicine Ham-Hong-Chho in Rats

1996 ◽  
Vol 24 (03n04) ◽  
pp. 231-240 ◽  
Author(s):  
Hwa-Woei Chih ◽  
Chun-Ching Lin ◽  
Kung-Sheng Tanga
Keyword(s):  
Liver Damage ◽  
Broad Spectrum ◽  
Folk Medicine ◽  
Protective Effects ◽  
Histological Observation ◽  
Bidens Pilosa ◽  
Potential Effectiveness ◽  
Liver Injuries ◽  
Hepatoprotective Effects ◽  
Hepatic Lesions

Bidens pilosa L. var minor (Blume) Sherff, B. pilosa L. and B. chilensis DC (compositae), commonly known as "Ham-hong-chho" in Taiwan, have been traditionally used for medicinal purposes. To clarify and compare the hepatoprotective effects of these three plants, we evaluated their potential effectiveness on CCl4- and acetaminophen-induced acute hepatic lesions in rats. The results indicated that the increase in SGOT and SGPT activities caused by CCl4 (3.0 mI/kg, s.c.) and acetaminophen administration (600 mg/kg, i.p.) could be significantly reduced by treating with the extracts of all the three kinds of "Ham-hong-chho" and the extract of B. chilensis exhibited the greatest hepatoprotective effects. These phenomena were also conflflDed by histological observation. Liver damage induced by CCl4 and acetaminophen was markedly improved in the extract of B. chilensis treated groups, while groups treated with the extracts of B. pilosa var minor and B. pilosa demonstrated only moderate protective effects. The pharmacological and pathological effects of these three crude groups were compared with Bupleurum chinense, which has been reported previously as a treatment criteria in the CCl4 model, and with silymarin as a standard reference medicine in the acetaminophen model. The results suggest that B. pilosa var minor, B. pilosa and B. chilensis can protect liver injuries from various hepatotoxins and have potential as broad spectrum antihepatic agents.

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