Theacrine, a Purine Alkaloid Obtained fromCamellia assamicavar.kucha, Attenuates Restraint Stress-Provoked Liver Damage in Mice

2013 ◽  
Vol 61 (26) ◽  
pp. 6328-6335 ◽  
Author(s):  
Wei-Xi Li ◽  
Yi-Fang Li ◽  
Yu-Jia Zhai ◽  
Wei-Min Chen ◽  
Hiroshi Kurihara ◽  
...  
Keyword(s):  
Liver Damage ◽  
Restraint Stress ◽  
Purine Alkaloid

scholarly journals Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hao-Jie Pu ◽  
Yun-Feng Cao ◽  
Rong-Rong He ◽  
Zhi-Long Zhao ◽  
Jin-Hui Song ◽  
...  
Keyword(s):  
Free Radicals ◽  
Liver Damage ◽  
Restraint Stress ◽  
Liver Cells ◽  
Protective Effects ◽  
Male Mice ◽  
Stress Effects ◽  
Restraint Tube ◽  
Hepatoprotective Effects ◽  
The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

Bilberry extract protect restraint stress-induced liver damage through attenuating mitochondrial dysfunction

Fitoterapia ◽  
2010 ◽  
Vol 81 (8) ◽  
pp. 1094-1101 ◽  
Author(s):  
Li Bao ◽  
Keiichi Abe ◽  
Philip Tsang ◽  
Jie-Kun Xu ◽  
Xin-Sheng Yao ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Liver Damage ◽  
Restraint Stress ◽  
Bilberry Extract

Protective Effects of Bilberry (Vaccinium myrtillusL.) Extract on Restraint Stress-Induced Liver Damage in Mice

2008 ◽  
Vol 56 (17) ◽  
pp. 7803-7807 ◽  
Author(s):  
Li Bao ◽  
Xin-Sheng Yao ◽  
Chin-Chin Yau ◽  
Daniel Tsi ◽  
Chew-Sern Chia ◽  
...  
Keyword(s):  
Liver Damage ◽  
Restraint Stress ◽  
Protective Effects

Protective effect of extract of chicken meat on restraint stress-induced liver damage in mice

2012 ◽  
Vol 3 (6) ◽  
pp. 662 ◽  
Author(s):  
Yu-Jia Zhai ◽  
Rong-Rong He ◽  
Bun Tsoi ◽  
Yi-Fang Li ◽  
Xiao-Di Li ◽  
...  
Keyword(s):  
Protective Effect ◽  
Liver Damage ◽  
Restraint Stress ◽  
Chicken Meat

scholarly journals Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pradeep K. Shukla ◽  
Avtar S. Meena ◽  
Kesha Dalal ◽  
Cherie Canelas ◽  
Geetha Samak ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Tight Junction ◽  
Liver Damage ◽  
Restraint Stress ◽  
Tissue Injury ◽  
Mucosal Barrier ◽  
Chronic Restraint Stress ◽  
Barrier Dysfunction ◽  
Corticosterone Treatment ◽  
Tight Junction Disruption

AbstractAlcohol use disorders are associated with altered stress responses, but the impact of stress or stress hormones on alcohol-associated tissue injury remain unknown. We evaluated the effects of chronic restraint stress on alcohol-induced gut barrier dysfunction and liver damage in mice. To determine whether corticosterone is the stress hormone associated with the stress-induced effects, we evaluated the effect of chronic corticosterone treatment on alcoholic tissue injury at the Gut-Liver-Brain (GLB) axis. Chronic restraint stress synergized alcohol-induced epithelial tight junction disruption and mucosal barrier dysfunction in the mouse intestine. These effects of stress on the gut were reproduced by corticosterone treatment. Corticosterone synergized alcohol-induced expression of inflammatory cytokines and chemokines in the colonic mucosa, and it potentiated the alcohol-induced endotoxemia and systemic inflammation. Corticosterone also potentiated alcohol-induced liver damage and neuroinflammation. Metagenomic analyses of 16S RNA from fecal samples indicated that corticosterone modulates alcohol-induced changes in the diversity and abundance of gut microbiota. In Caco-2 cell monolayers, corticosterone dose-dependently potentiated ethanol and acetaldehyde-induced tight junction disruption and barrier dysfunction. These data indicate that chronic stress and corticosterone exacerbate alcohol-induced mucosal barrier dysfunction, endotoxemia, and systemic alcohol responses. Corticosterone-mediated promotion of alcohol-induced intestinal epithelial barrier dysfunction and modulation of gut microbiota may play a crucial role in the mechanism of stress-induced promotion of alcohol-associated tissue injury at the GLB axis.

Ultrastructural Changes in Patients With Heat Stroke

1970 ◽  
Vol 28 ◽  
pp. 210-211
Author(s):  
O. T. Minick ◽  
M. C. Kew
Keyword(s):  
Liver Damage ◽  
Heat Stroke ◽  
Free State ◽  
Ultrastructural Changes ◽  
Gold Mines

The effects of heat stroke on hepatic structure were studied in 32 Bantu patients who worked underground in the Transvaal and Orange Free State Gold Mines.Judging from biochemical and morphologic findings, liver damage is an invariable complication of heat stroke. In the milder cases (90 per cent) raised enzyme levels, bromsulphalein retention, and increased prothrombin times were the most common abnormalities.

Acute restraint stress has a similar effect on visceral sensitivity in different types of maternal deprivation in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A715-A715
Author(s):  
A ROSZTOCZY ◽  
S BRADESI ◽  
C BEAUFRAND ◽  
J FIORAMONTI ◽  
T WITTMANN ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Maternal Deprivation ◽  
Visceral Sensitivity ◽  
Acute Restraint Stress ◽  
Different Types

Alcohol and its Relation to Liver Damage

1961 ◽  
Vol 41 (5) ◽  
pp. 443-451 ◽  
Author(s):  
Gerald Klatskin
Keyword(s):  
Liver Damage

Chronic Adhesive, Pericarditis Due to the Rheumatic State, Associated With Liver Damage, Serous Effusions, and Pigmentation

1951 ◽  
Vol 17 (2) ◽  
pp. 294-303 ◽  
Author(s):  
Clarence McMurray ◽  
David Caper ◽  
W.E. Cornatzer
Keyword(s):  
Liver Damage
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