Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake

Irene Muñoz-González; Ana Jiménez-Girón; Pedro J. Martín-Álvarez; Begoña Bartolomé; M. Victoria Moreno-Arribas

doi:10.1021/jf4025135

Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake

Journal of Agricultural and Food Chemistry ◽

10.1021/jf4025135 ◽

2013 ◽

Vol 61 (39) ◽

pp. 9470-9479 ◽

Cited By ~ 53

Author(s):

Irene Muñoz-González ◽

Ana Jiménez-Girón ◽

Pedro J. Martín-Álvarez ◽

Begoña Bartolomé ◽

M. Victoria Moreno-Arribas

Keyword(s):

Red Wine ◽

Human Feces ◽

Phenolic Metabolites

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Comparative Study of Microbial-Derived Phenolic Metabolites in Human Feces after Intake of Gin, Red Wine, and Dealcoholized Red Wine

Journal of Agricultural and Food Chemistry ◽

10.1021/jf400678d ◽

2013 ◽

Vol 61 (16) ◽

pp. 3909-3915 ◽

Cited By ~ 53

Author(s):

Ana Jiménez-Girón ◽

María Isabel Queipo-Ortuño ◽

Maria Boto-Ordóñez ◽

Irene Muñoz-González ◽

Fernando Sánchez-Patán ◽

...

Keyword(s):

Comparative Study ◽

Red Wine ◽

Human Feces ◽

Phenolic Metabolites

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In Vitro Fermentation of a Red Wine Extract by Human Gut Microbiota: Changes in Microbial Groups and Formation of Phenolic Metabolites

Journal of Agricultural and Food Chemistry ◽

10.1021/jf2040115 ◽

2012 ◽

Vol 60 (9) ◽

pp. 2136-2147 ◽

Cited By ~ 114

Author(s):

Fernando Sánchez-Patán ◽

Carolina Cueva ◽

Maria Monagas ◽

Gemma E. Walton ◽

Glenn R. Gibson M. ◽

...

Keyword(s):

Gut Microbiota ◽

Red Wine ◽

Human Gut ◽

In Vitro Fermentation ◽

Phenolic Metabolites ◽

Human Gut Microbiota ◽

Microbial Groups

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Metabolome-based clustering after moderate wine consumption

OENO One ◽

10.20870/oeno-one.2020.54..2983 ◽

2020 ◽

Vol 54 (3) ◽

pp. 455-467 ◽

Cited By ~ 1

Author(s):

Adelaida Esteban-Fernández ◽

Clara Ibañez ◽

Carolina Simó ◽

Begoña Bartolomé ◽

Victoria Moreno Arribas

Keyword(s):

Clinical Trials ◽

Healthy Volunteers ◽

Red Wine ◽

Nutritional Interventions ◽

Phenolic Metabolites ◽

Wine Consumption ◽

Wine Polyphenols ◽

Relative Production ◽

First Time ◽

Metabolomic Approach

Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols.

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