scholarly journals Metabolome-based clustering after moderate wine consumption

OENO One ◽  
2020 ◽  
Vol 54 (3) ◽  
pp. 455-467 ◽  
Author(s):  
Adelaida Esteban-Fernández ◽  
Clara Ibañez ◽  
Carolina Simó ◽  
Begoña Bartolomé ◽  
Victoria Moreno Arribas
Keyword(s):  
Clinical Trials ◽  
Healthy Volunteers ◽  
Red Wine ◽  
Nutritional Interventions ◽  
Phenolic Metabolites ◽  
Wine Consumption ◽  
Wine Polyphenols ◽  
Relative Production ◽  
First Time ◽  
Metabolomic Approach

Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols.

Moderate red wine consumption improves hemorheological parameters in healthy volunteers

2014 ◽  
Vol 56 (1) ◽  
pp. 13-23 ◽  
Author(s):  
A. Toth ◽  
B. Sandor ◽  
J. Papp ◽  
M. Rabai ◽  
D. Botor ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Red Wine ◽  
Wine Consumption

scholarly journals The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers

2005 ◽  
Vol 93 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Catherine Tsang ◽  
Siobhan Higgins ◽  
Garry G. Duthie ◽  
Susan J. Duthie ◽  
Moira Howie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Volunteers ◽  
Antioxidant Status ◽  
Red Wine ◽  
Conjugated Dienes ◽  
Controlled Study ◽  
Total Phenolic ◽  
Resonance Spectroscopy ◽  
Oxidised Ldl ◽  
Wine Consumption

The effects of moderate red wine consumption on the antioxidant status and indices of lipid peroxidation and oxidative stress associated with CHD were investigated. A randomised, controlled study was performed with twenty free-living healthy volunteers. Subjects in the red wine group consumed 375 ml red wine daily for 2 weeks. We measured the total concentration of phenolics and analysed the individual phenolics in the wine and plasma by HPLC with tandem MS. The antioxidant capacity of plasma was measured with electron spin resonance spectroscopy while homocysteine and fasting plasma lipids were also determined. The production of conjugated dienes and thiobarbituric acid-reactive substances (TBARS) were measured in Cu-oxidised LDL. Plasma total phenolic concentrations increased significantly after 2 weeks of daily red wine consumption (P≤0·001) and trace levels of metabolites, mainly glucuronides and methyl glucuronides of (+)-catechin and (−)-epicatechin, were detected in the plasma of the red wine group. These flavan-3-ol metabolites were not detected in plasma from the control group. The maximum concentrations of conjugated dienes and TBARS in Cu-oxidised LDL were reduced (P≤0·05) and HDL cholesterol concentrations increased (P≤0·05) following red wine consumption. The findings from the present study provide some evidence for potential protective effects of moderate consumption of red wine in healthy volunteers.

scholarly journals Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers

Diseases ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 106 ◽  
Author(s):  
Souheila Amor ◽  
Pauline Châlons ◽  
Virginie Aires ◽  
Dominique Delmas
Keyword(s):  
Red Wine ◽  
Heart Diseases ◽  
Coronary Heart Diseases ◽  
Wine Consumption ◽  
Positive Effects ◽  
Polyphenolic Composition ◽  
Polyphenolic Extract ◽  
Wine Polyphenols

Wine has been popular worldwide for many centuries and currently remains an important component of our diet. Scientific interest in wine and its health effects has grown considerably since the 1990s with the emergence of the “French Paradox” concept, correlating moderate wine consumption, a characteristic of the Mediterranean diet, and low incidence of coronary heart diseases. Since then, the positive effects on health, health promotion, disease prevention, and disease prognosis of moderate wine consumption, in particular red wine, have been attributed to its polyphenolic compounds such as resveratrol, quercetin, and other flavonoids acting as antioxidants. Several epidemiological, in vivo and in vitro, studies have reported that moderate red wine or red wine polyphenolic extract consumption may be active in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, degenerative pathologies, and cancer. The aim of this review is to summarize the current findings about the effects of red wine polyphenols on cancer and to discuss how the polyphenolic composition of red wine may influence its chemopreventive properties.

scholarly journals Wine polyphenols and promotion of cardiac health

2004 ◽  
Vol 17 (1) ◽  
pp. 111-130 ◽  
Author(s):  
Karen A. Cooper ◽  
Mridula Chopra ◽  
David I. Thurnham
Keyword(s):  
Red Wine ◽  
Plasma Lipids ◽  
Present Review ◽  
Wine Consumption ◽  
Cardiac Health ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
The Uk

Wine polyphenols are considered to have beneficial effects on CHD and atherosclerosis. The consumption of red wine is high in Italy and France, approximately four times greater than that in the UK. This disparity in red wine consumption is thought to be the reason for the ‘French paradox’, where France was shown to have a coronary mortality rate close to that of China or Japan despite saturated fat intakes and cholesterol levels similar to the UK and USA. In the present review, we discuss the effects of wine and some of its polyphenol constituents on early pathological indicators of CHD such as plasma lipids, the endothelium and vasculature, platelets and serum antioxidant activity. The review also examines whether the polyphenols or the alcohol in wine is responsible for the effects on markers of heart disease. The present review concludes that red wine polyphenols have little effect on plasma lipid concentrations but wine consumption appears to reduce the susceptibility of LDL to oxidation and increase serum antioxidant capacity. However, these effects do depend on the amount of wine and period of supplementation. Authors who have examined specific polyphenols suggest that some phenolics appear to have endothelium-dependent vaso-relaxing abilities and some a positive effect on NO concentrations. Red wine phenolics also have an inhibitory effect on platelet aggregation, and individual phenolics also have a similar effectin vitro, although it should be noted that there are often discrepancies as large as ten-fold between the concentrations of polyphenolics testedin vitroand their measured levelsin vivo. Evidence suggests that alcohol has a positive synergistic effect with wine polyphenols on some atherosclerotic risk factors. Thus evidence that wine drinking is beneficial for cardiac health continues to accumulate but more research is required to understand fully and exactly the functions of red wine polyphenols.

scholarly journals Moderate Wine Consumption Reduces Faecal Water Cytotoxicity in Healthy Volunteers

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2716
Author(s):  
Irene Zorraquín-Peña ◽  
Dolores González de Llano ◽  
Alba Tamargo ◽  
M. Victoria Moreno-Arribas ◽  
Begoña Bartolomé
Keyword(s):  
Cell Viability ◽  
Healthy Volunteers ◽  
Cell Lines ◽  
Red Wine ◽  
Favourable Effect ◽  
Control Group ◽  
Gut Health ◽  
Wine Consumption ◽  
Hct 116 ◽  
Assay Conditions

There are some studies that suggest that moderate consumption of wine, as part of a healthy and balanced diet, has a favourable effect on intestinal health. This study evaluates the effect of moderate wine consumption on faecal water (FW) cytotoxicity as a parameter of gut health. To that end, faecal samples before and after a red wine intervention study (250 mL of wine/day, 4 weeks) in healthy volunteers (n = 8) and in a parallel control group (n = 3) were collected and assayed for in vitro FW cytotoxicity. Two reference compounds, phenol and p-cresol, were used for assessing the cytotoxicity assays using two colon epithelial cell lines (HT-29 and HCT 116) and different assay conditions (FW dilution and incubation time). For the two cell lines and all assay conditions, the means of percentage cell viability were higher (lower cytotoxicity) for samples collected after the red wine intervention than for those collected before, although significant (p < 0.05) differences were only found in certain assay conditions for both cell lines. Significant positive correlations between the percentage cell viability and the contents of some faecal metabolites (short-chain fatty acids (SCFA) and phenolic acids (PA)) were found for the more resistant cell line (HCT 116), suggesting that the reduction in FW cytotoxicity observed after moderate red wine consumption was related to the production of microbial-derived metabolites such as SCFA and PA, whose faecal contents have been shown to increase after wine consumption. FW cytotoxicity can be deemed as a holistic biomarker that involves diet, gut microbiota and host.

The increase in human plasma antioxidant capacity after red wine consumption is due to both plasma urate and wine polyphenols

2008 ◽  
Vol 197 (1) ◽  
pp. 250-256 ◽  
Author(s):  
Darko Modun ◽  
Ivana Music ◽  
Jonatan Vukovic ◽  
Ivica Brizic ◽  
Visnja Katalinic ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Human Plasma ◽  
Red Wine ◽  
Wine Consumption ◽  
Plasma Antioxidant Capacity ◽  
Wine Polyphenols ◽  
Plasma Urate ◽  
Plasma Antioxidant

Moderate red wine consumption in healthy volunteers reduced plasma clearance of apolipoprotein AII

1999 ◽  
Vol 29 (5) ◽  
pp. 387-394 ◽  
Author(s):  
Gottrand ◽  
Beghin ◽  
Duhal ◽  
Lacroix ◽  
Bonte ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Plasma Clearance ◽  
Red Wine ◽  
Wine Consumption

Element and redox homeostasis in rats after red wine consumption

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
K Szentmihályi ◽  
Z May ◽  
H Fébel ◽  
G Bekő ◽  
A Blázovics
Keyword(s):  
Red Wine ◽  
Redox Homeostasis ◽  
Wine Consumption
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