Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification

2019 ◽  
Vol 141 (32) ◽  
pp. 12738-12743 ◽  
Author(s):  
Xu Chang ◽  
Chao Zhang ◽  
Cheng Lv ◽  
Yang Sun ◽  
Mingzhi Zhang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Live Cell ◽  
Logic Device ◽  
Cell Identification

Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

2021 ◽  
Vol 57 (31) ◽  
pp. 3816-3819
Author(s):  
Xiangnan Wang ◽  
Lan Liu ◽  
Han Wu ◽  
Zhenkun Wu ◽  
Li-Juan Tang ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Live Cell ◽  
Cell Recognition ◽  
Cell Identification ◽  
Logic Operations

A programmable and activatable DNA cascade circuit has been developed on live cell membranes for accurate cancer cell identification and precise gene silencing via dual-aptamer based AND logic operations.

Highly Specific, Single‐step Cancer Cell Isolation with Multi‐Aptamer‐Mediated Proximity Ligation on Live Cell Membranes

2020 ◽  
Vol 132 (52) ◽  
pp. 23770-23774
Author(s):  
Qianqian Gao ◽  
Yumeng Zhao ◽  
Kangli Xu ◽  
Chao Zhang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Cell Isolation ◽  
Single Step ◽  
Live Cell ◽  
Proximity Ligation ◽  
Cancer Cell Isolation

Highly Specific, Single‐step Cancer Cell Isolation with Multi‐Aptamer‐Mediated Proximity Ligation on Live Cell Membranes

2020 ◽  
Vol 59 (52) ◽  
pp. 23564-23568
Author(s):  
Qianqian Gao ◽  
Yumeng Zhao ◽  
Kangli Xu ◽  
Chao Zhang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Cell Isolation ◽  
Single Step ◽  
Live Cell ◽  
Proximity Ligation ◽  
Cancer Cell Isolation

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell

scholarly journals The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles

2020 ◽  
Author(s):  
Carla Ferreri ◽  
Anna Sansone ◽  
Sandra Buratta ◽  
Lorena Urbanelli ◽  
Eva Costanzi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cell Membranes ◽  
Saturated Fatty Acids ◽  
Prostatic Adenocarcinoma ◽  
Fatty Acid Isomer ◽  
Adenocarcinoma Cell

A new pathway leading to the n-10 fatty acid series has been recently evidenced, starting from sapienic acid - a monounsaturated fatty acid (MUFA) resulting from the transformation of palmitic acid by delta-6 desaturase. Sapienic acid attracts attention as novel marker of cancer cell plasticity. Here, we analyzed fatty acids including the n-10 fatty acid contents, and compared for the first time cell membranes and the corresponding extracellular vesicles (EV) of two human prostatic adenocarcinoma cell lines of different aggressiveness (PC3 and LNCaP). The n-10 components were 9-13% of the total fatty acids in both cancer cell lines and EVs, with total MUFA levels significantly higher in EVs of the most aggressive cell type (PC3). High sapienic/palmitoleic ratios indicated the preference for delta-6 vs. delta-9 desaturase enzymatic activity in these cell lines. The expressions analysis of enzymes involved in desaturation and elongation by qRT-PCR showed a higher desaturase activity in PC3 and a higher elongase activity toward polyunsaturated fatty acids than toward saturated fatty acids, compared to LNCaP cells. Our results improve the present knowledge in cancer fatty acid metabolism and lipid phenotypes, highlighting EV lipidomics to monitor positional fatty acid isomer profiles and MUFA levels in cancer.

The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43

FEBS Journal ◽  
2021 ◽  
Author(s):  
Claudia Herrera‐León ◽  
Francisco Ramos‐Martín ◽  
Viviane Antonietti ◽  
Pascal Sonnet ◽  
Nicola D’Amelio
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Anticancer Peptide ◽  
Phosphatidylserine Exposure ◽  
The Impact

scholarly journals An artificial intelligent platform for live cell identification and the detection of cross-contamination

2020 ◽  
Vol 8 (11) ◽  
pp. 697-697
Author(s):  
Ruixin Wang ◽  
Dongni Wang ◽  
Dekai Kang ◽  
Xusen Guo ◽  
Chong Guo ◽  
...  
Keyword(s):  
Live Cell ◽  
Cross Contamination ◽  
Artificial Intelligent ◽  
Cell Identification

Super-resolution imaging of cancer-associated carbohydrates using aptamer probes

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14879-14886 ◽  
Author(s):  
Yingying Jing ◽  
Junling Chen ◽  
Lulu Zhou ◽  
Jiayin Sun ◽  
Mingjun Cai ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Super Resolution ◽  
High Expression ◽  
Resolution Imaging ◽  
Potential Interactions

Relying on fluorophore-conjugated aptamers, we revealed the high expression and clustered distribution of globo H on cancer cell membranes and uncovered the potential interactions between cancer-associated carbohydrates via super-resolution imaging.

Erythrocyte membrane nano-capsules: biomimetic delivery and controlled release of photothermal–photochemical coupling agents for cancer cell therapy

2020 ◽  
Vol 49 (8) ◽  
pp. 2645-2651 ◽  
Author(s):  
Shihao Li ◽  
Lin Zhang
Keyword(s):  
Controlled Release ◽  
Cell Therapy ◽  
Blood Cell ◽  
Erythrocyte Membrane ◽  
Cancer Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Cell Membranes ◽  
Coupling Agents ◽  
Red Blood Cell Membranes

A biomimetic nanoreactor Au/TiO2@RBC was fabricated for photothermal therapy by co-encapsulating photothermal agents and photocatalysts in red blood cell membranes.

Sign in / Sign up

Export Citation Format

Share Document