Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

2021 ◽  
Vol 57 (31) ◽  
pp. 3816-3819
Author(s):  
Xiangnan Wang ◽  
Lan Liu ◽  
Han Wu ◽  
Zhenkun Wu ◽  
Li-Juan Tang ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Live Cell ◽  
Cell Recognition ◽  
Cell Identification ◽  
Logic Operations

A programmable and activatable DNA cascade circuit has been developed on live cell membranes for accurate cancer cell identification and precise gene silencing via dual-aptamer based AND logic operations.

Highly Specific, Single‐step Cancer Cell Isolation with Multi‐Aptamer‐Mediated Proximity Ligation on Live Cell Membranes

2020 ◽  
Vol 132 (52) ◽  
pp. 23770-23774
Author(s):  
Qianqian Gao ◽  
Yumeng Zhao ◽  
Kangli Xu ◽  
Chao Zhang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Cell Isolation ◽  
Single Step ◽  
Live Cell ◽  
Proximity Ligation ◽  
Cancer Cell Isolation

Highly Specific, Single‐step Cancer Cell Isolation with Multi‐Aptamer‐Mediated Proximity Ligation on Live Cell Membranes

2020 ◽  
Vol 59 (52) ◽  
pp. 23564-23568
Author(s):  
Qianqian Gao ◽  
Yumeng Zhao ◽  
Kangli Xu ◽  
Chao Zhang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Cell Isolation ◽  
Single Step ◽  
Live Cell ◽  
Proximity Ligation ◽  
Cancer Cell Isolation

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell

Cancer cell recognition by a Cys-reactive turn-on significant enhanced fluorescent emission targeting biotin receptors

2020 ◽  
Vol 304 ◽  
pp. 127431 ◽  
Author(s):  
Xueying Pei ◽  
Fangjun Huo ◽  
Yongkang Yue ◽  
Tinggui Chen ◽  
Caixia Yin
Keyword(s):  
Cancer Cell ◽  
Cell Recognition ◽  
Fluorescent Emission ◽  
Turn On

scholarly journals Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy

2007 ◽  
Vol 6 (5) ◽  
pp. 795-801 ◽  
Author(s):  
Dineo Khabele ◽  
Deok-Soo Son ◽  
Angelika K. Parl ◽  
Gary L. Goldberg ◽  
Leonard H. Augenlicht ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Gene Silencing ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Ovarian Cancer Cell ◽  
Class I ◽  
Cancer Cell Growth ◽  
Drug Induced ◽  
Or Gene

scholarly journals The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles

2020 ◽  
Author(s):  
Carla Ferreri ◽  
Anna Sansone ◽  
Sandra Buratta ◽  
Lorena Urbanelli ◽  
Eva Costanzi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cell Membranes ◽  
Saturated Fatty Acids ◽  
Prostatic Adenocarcinoma ◽  
Fatty Acid Isomer ◽  
Adenocarcinoma Cell

A new pathway leading to the n-10 fatty acid series has been recently evidenced, starting from sapienic acid - a monounsaturated fatty acid (MUFA) resulting from the transformation of palmitic acid by delta-6 desaturase. Sapienic acid attracts attention as novel marker of cancer cell plasticity. Here, we analyzed fatty acids including the n-10 fatty acid contents, and compared for the first time cell membranes and the corresponding extracellular vesicles (EV) of two human prostatic adenocarcinoma cell lines of different aggressiveness (PC3 and LNCaP). The n-10 components were 9-13% of the total fatty acids in both cancer cell lines and EVs, with total MUFA levels significantly higher in EVs of the most aggressive cell type (PC3). High sapienic/palmitoleic ratios indicated the preference for delta-6 vs. delta-9 desaturase enzymatic activity in these cell lines. The expressions analysis of enzymes involved in desaturation and elongation by qRT-PCR showed a higher desaturase activity in PC3 and a higher elongase activity toward polyunsaturated fatty acids than toward saturated fatty acids, compared to LNCaP cells. Our results improve the present knowledge in cancer fatty acid metabolism and lipid phenotypes, highlighting EV lipidomics to monitor positional fatty acid isomer profiles and MUFA levels in cancer.

scholarly journals Dentin Sialophosphoprotein (DSPP) Gene-Silencing Inhibits Key Tumorigenic Activities in Human Oral Cancer Cell Line, OSC2

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e13974 ◽  
Author(s):  
Rajeshree Joshi ◽  
Amany Tawfik ◽  
Nneka Edeh ◽  
Veronica McCloud ◽  
Stephen Looney ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Gene Silencing ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Dentin Sialophosphoprotein ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line
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