Large, Tunable, and Reversible pH Changes by Merocyanine Photoacids

2021 ◽  
Author(s):  
Laura Wimberger ◽  
Shyamal K. K. Prasad ◽  
Martin D. Peeks ◽  
Joakim Andréasson ◽  
Timothy W. Schmidt ◽  
...  
Keyword(s):  
Ph Changes

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

pH Changes That Induce an Axial Ligand Effect on Nonheme Iron(IV) Oxo Complexes with an Appended Aminopropyl Functionality

2021 ◽  
Author(s):  
Reza Latifi ◽  
Taryn D. Palluccio ◽  
Wanhua Ye ◽  
Jennifer L. Minnick ◽  
Kwame S. Glinton ◽  
...  
Keyword(s):  
Axial Ligand ◽  
Nonheme Iron ◽  
Ligand Effect ◽  
Ph Changes ◽  
Oxo Complexes

Real-time tracking lysosomal pH changes under heatstroke and redox stress with a novel near-infrared emissive probe

Talanta ◽  
2021 ◽  
Vol 228 ◽  
pp. 122184
Author(s):  
Qingfeng Xia ◽  
Shumin Feng ◽  
Jiaxin Hong ◽  
Guoqiang Feng
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Redox Stress ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Real Time Tracking ◽  
Emissive Probe

scholarly journals 35 Vaginal pH changes due to the use of a controlled internal drug release (CIDR) and its effects on fertility of beef cows

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 25-26
Author(s):  
Nicholas W Dias ◽  
Claire L Timlin ◽  
Stefania Pancini ◽  
Nicholas W Dias ◽  
Zackary Seekford ◽  
...  
Keyword(s):  
Drug Release ◽  
Scoring System ◽  
Beef Cows ◽  
Ph Changes ◽  
Ph Values ◽  
Vaginal Ph ◽  
Pregnancy Status ◽  
System 1

Abstract The objective of this study was to evaluate changes in vaginal pH of beef cows enrolled in a 7-d CO-Synch+controlled internal drug release (CIDR) protocol and its effects on pregnancy. A total of 46 multiparous beef cows with no signs of vaginitis were enrolled. Individual vaginal flushes were collected from cows on D0, D7 and D10. Individual flushes were immediately analyzed for pH with a portable pH meter. As evidence of vaginitis, a CIDR score was determined at CIDR removal (D7), following a 1 to 4 scoring system: 1 = clean, no secretion; 2 = clean, clear secretion; 3 = purulent secretion; 4 = purulent secretion and blood. Pregnancy status was determined by rectal ultrasonography approximately 40 days after TAI. No cows had CIDR scores of 1 or 4, 19.6% of cows had a score of 2 and 80.4% a score of 3. Vaginal pH increased from D0 (6.88±0.007) to D7 (7.32±0.047), regardless of CIDR score (P &lt; 0.001). Cows with a CIDR score 2 had greater pH on D7 (7.35±0.084) than on D0 (6.90± 0.14; P = 0.001), and pH on D10 was intermediate (7.14±0.14; P = 0.14). Cows with CIDR score 3 had reduced pH on D10 (7.09±0.07) when compared to D7 (7.29±0.04; P = 0.003), but greater pH on D10 than on D0 (6.87±0.07; P = 0.007). There was a pregnancy by day interaction for pH values (P = 0.046). Pregnant cows had greater vaginal pH in comparison with non-pregnant cows on D0 (6.99±0.081 and 6.68±0.09, respectively; P = 0.01) and D10 (7.26±0.08 and 6.89±0.09, respectively; P = 0.006), but not on D7 (7.34±0.05 and 7.27±0.06, respectively; P = 0.38). Non-pregnant cows had reduced vaginal pH on D10 in comparison to D7 (6.89±0.09 and 7.27±0.06, respectively; P &lt; 0.001), whereas pregnant cows had similar vaginal pH on D10 and D7 (7.26±0.08 and 7.34±0.05, respectively; P = 0.35). We conclude that CIDR increases vaginal pH overtime and greater pH at TAI is beneficial to fertility.

Effects of pH Changes on Ion and 2,4-D Uptake of Wheat Roots

1979 ◽  
Vol 47 (2) ◽  
pp. 77-80 ◽  
Author(s):  
FERENC ZSOLDOS ◽  
ERNST HAUNOLD
Keyword(s):  
Wheat Roots ◽  
Ph Changes ◽  
Effects Of Ph

OBSERVATIONS ON AMYLOLYTIC BACTERIA: III. CULTURAL CONDITIONS INFLUENCING THE BREAKDOWN OF STARCH BY STENOTHERMOPHILIC BACTERIA BELONGING TO BACILLUS STEAROTHERMOPHILUS

1952 ◽  
Vol 30 (4) ◽  
pp. 360-370 ◽  
Author(s):  
Egon Stark ◽  
P. A. Tetrault
Keyword(s):  
Yeast Extract ◽  
Bacillus Stearothermophilus ◽  
Soluble Starch ◽  
The Other ◽  
Ph Changes ◽  
Proteose Peptone ◽  
Cultural Conditions ◽  
Initial Ph ◽  
Commercial Medium ◽  
Agar Media

Thirty-five cultures of Bacillus stearothermophilus hydrolyzed five starches under various cultural conditions. Hydrolysis occurred regardless of the type, brand, or batch of starch; regardless of the initial pH or of the subsequent pH changes of the medium. Starch in broth was better attacked than in agar media. Some cultures hydrolyzed 0.5%, but not 1% starch; others hydrolyzed easily 10% soluble starch. Length of incubation was important. Certain cultures never formed acid or sugar from starch. Dextrinization was a more reliable indication of starch hydrolysis than was the formation of acid or sugar. Soluble starch gave more consistent results in repeated experiments than did nonsoluble starches. The type of protein medium determines strongly the formation of amylase. Trypticase was the best commercial medium, yeast extract came second. The other 10 media yielded fewer amylolytic cultures. Yeast extract added to media enhanced amylase formation, except with trypticase. Tryptose, proteose-peptone, and neopeptone inhibited the growth of most cultures.

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