Activating a DNA Nanomachine via Computation across Cancer Cell Membranes for Precise Therapy of Solid Tumors

2021 ◽  
Author(s):  
Yue Zhang ◽  
Weiwei Chen ◽  
Yanyun Fang ◽  
Xiaobo Zhang ◽  
Ying Liu ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Dna Nanomachine

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell

scholarly journals The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles

2020 ◽  
Author(s):  
Carla Ferreri ◽  
Anna Sansone ◽  
Sandra Buratta ◽  
Lorena Urbanelli ◽  
Eva Costanzi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cell Membranes ◽  
Saturated Fatty Acids ◽  
Prostatic Adenocarcinoma ◽  
Fatty Acid Isomer ◽  
Adenocarcinoma Cell

A new pathway leading to the n-10 fatty acid series has been recently evidenced, starting from sapienic acid - a monounsaturated fatty acid (MUFA) resulting from the transformation of palmitic acid by delta-6 desaturase. Sapienic acid attracts attention as novel marker of cancer cell plasticity. Here, we analyzed fatty acids including the n-10 fatty acid contents, and compared for the first time cell membranes and the corresponding extracellular vesicles (EV) of two human prostatic adenocarcinoma cell lines of different aggressiveness (PC3 and LNCaP). The n-10 components were 9-13% of the total fatty acids in both cancer cell lines and EVs, with total MUFA levels significantly higher in EVs of the most aggressive cell type (PC3). High sapienic/palmitoleic ratios indicated the preference for delta-6 vs. delta-9 desaturase enzymatic activity in these cell lines. The expressions analysis of enzymes involved in desaturation and elongation by qRT-PCR showed a higher desaturase activity in PC3 and a higher elongase activity toward polyunsaturated fatty acids than toward saturated fatty acids, compared to LNCaP cells. Our results improve the present knowledge in cancer fatty acid metabolism and lipid phenotypes, highlighting EV lipidomics to monitor positional fatty acid isomer profiles and MUFA levels in cancer.

The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43

FEBS Journal ◽  
2021 ◽  
Author(s):  
Claudia Herrera‐León ◽  
Francisco Ramos‐Martín ◽  
Viviane Antonietti ◽  
Pascal Sonnet ◽  
Nicola D’Amelio
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Anticancer Peptide ◽  
Phosphatidylserine Exposure ◽  
The Impact

Super-resolution imaging of cancer-associated carbohydrates using aptamer probes

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14879-14886 ◽  
Author(s):  
Yingying Jing ◽  
Junling Chen ◽  
Lulu Zhou ◽  
Jiayin Sun ◽  
Mingjun Cai ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Super Resolution ◽  
High Expression ◽  
Resolution Imaging ◽  
Potential Interactions

Relying on fluorophore-conjugated aptamers, we revealed the high expression and clustered distribution of globo H on cancer cell membranes and uncovered the potential interactions between cancer-associated carbohydrates via super-resolution imaging.

Erythrocyte membrane nano-capsules: biomimetic delivery and controlled release of photothermal–photochemical coupling agents for cancer cell therapy

2020 ◽  
Vol 49 (8) ◽  
pp. 2645-2651 ◽  
Author(s):  
Shihao Li ◽  
Lin Zhang
Keyword(s):  
Controlled Release ◽  
Cell Therapy ◽  
Blood Cell ◽  
Erythrocyte Membrane ◽  
Cancer Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Cell Membranes ◽  
Coupling Agents ◽  
Red Blood Cell Membranes

A biomimetic nanoreactor Au/TiO2@RBC was fabricated for photothermal therapy by co-encapsulating photothermal agents and photocatalysts in red blood cell membranes.

Abstract 746: Notch-1 expression in human cancer cell lines and solid tumors by validated immunohistochemistry

2012 ◽  
Author(s):  
Dat Nguyen ◽  
Sara Witter ◽  
Joseph E. Tomaszewski ◽  
Percy Ivy ◽  
James H. Doroshow ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Notch 1 ◽  
Human Cancer Cell Lines

Abstract 2511: ErbB2 receptor levels in patient-derived spheroids vs. solid tumors reveal high ovarian cancer cell plasticity

2018 ◽  
Author(s):  
Mara P. Steinkamp ◽  
Ashley Remy ◽  
Irina Lagutina ◽  
Carolyn Y. Muller ◽  
Diane S. Lidke ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Solid Tumors ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cell Plasticity ◽  
Erbb2 Receptor

Abstract A60: Hyaluronan and cancer cell derived swelling of solid tumors and implications for cancer therapy

2017 ◽  
Author(s):  
Chrysovalantis Voutouri ◽  
Christiana Polydorou ◽  
Panagiotis Papageorgis ◽  
Triantafyllos Stylianopoulos
Keyword(s):  
Cancer Therapy ◽  
Solid Tumors ◽  
Cancer Cell
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