Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form

2004 ◽  
Vol 34 (9) ◽  
pp. 2620-2629 ◽  
Author(s):  
Juha Hakulinen ◽  
Sami Junnikkala ◽  
Timo Sorsa ◽  
Seppo Meri
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Soluble Form ◽  
Membrane Cofactor Protein ◽  
Complement Inhibitor

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell

scholarly journals The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles

2020 ◽  
Author(s):  
Carla Ferreri ◽  
Anna Sansone ◽  
Sandra Buratta ◽  
Lorena Urbanelli ◽  
Eva Costanzi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cell Membranes ◽  
Saturated Fatty Acids ◽  
Prostatic Adenocarcinoma ◽  
Fatty Acid Isomer ◽  
Adenocarcinoma Cell

A new pathway leading to the n-10 fatty acid series has been recently evidenced, starting from sapienic acid - a monounsaturated fatty acid (MUFA) resulting from the transformation of palmitic acid by delta-6 desaturase. Sapienic acid attracts attention as novel marker of cancer cell plasticity. Here, we analyzed fatty acids including the n-10 fatty acid contents, and compared for the first time cell membranes and the corresponding extracellular vesicles (EV) of two human prostatic adenocarcinoma cell lines of different aggressiveness (PC3 and LNCaP). The n-10 components were 9-13% of the total fatty acids in both cancer cell lines and EVs, with total MUFA levels significantly higher in EVs of the most aggressive cell type (PC3). High sapienic/palmitoleic ratios indicated the preference for delta-6 vs. delta-9 desaturase enzymatic activity in these cell lines. The expressions analysis of enzymes involved in desaturation and elongation by qRT-PCR showed a higher desaturase activity in PC3 and a higher elongase activity toward polyunsaturated fatty acids than toward saturated fatty acids, compared to LNCaP cells. Our results improve the present knowledge in cancer fatty acid metabolism and lipid phenotypes, highlighting EV lipidomics to monitor positional fatty acid isomer profiles and MUFA levels in cancer.

scholarly journals Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines

2011 ◽  
Vol 02 (01) ◽  
pp. 40-53 ◽  
Author(s):  
Yoshiko Yasuda ◽  
Yasuhiro Maeda ◽  
Satoshi Hara ◽  
Motoyoshi Tanaka ◽  
Eiji Koike ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Erythropoietin Receptor ◽  
Soluble Form ◽  
Constitutively Active

The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43

FEBS Journal ◽  
2021 ◽  
Author(s):  
Claudia Herrera‐León ◽  
Francisco Ramos‐Martín ◽  
Viviane Antonietti ◽  
Pascal Sonnet ◽  
Nicola D’Amelio
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Anticancer Peptide ◽  
Phosphatidylserine Exposure ◽  
The Impact

Super-resolution imaging of cancer-associated carbohydrates using aptamer probes

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14879-14886 ◽  
Author(s):  
Yingying Jing ◽  
Junling Chen ◽  
Lulu Zhou ◽  
Jiayin Sun ◽  
Mingjun Cai ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Super Resolution ◽  
High Expression ◽  
Resolution Imaging ◽  
Potential Interactions

Relying on fluorophore-conjugated aptamers, we revealed the high expression and clustered distribution of globo H on cancer cell membranes and uncovered the potential interactions between cancer-associated carbohydrates via super-resolution imaging.

Erythrocyte membrane nano-capsules: biomimetic delivery and controlled release of photothermal–photochemical coupling agents for cancer cell therapy

2020 ◽  
Vol 49 (8) ◽  
pp. 2645-2651 ◽  
Author(s):  
Shihao Li ◽  
Lin Zhang
Keyword(s):  
Controlled Release ◽  
Cell Therapy ◽  
Blood Cell ◽  
Erythrocyte Membrane ◽  
Cancer Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Cell Membranes ◽  
Coupling Agents ◽  
Red Blood Cell Membranes

A biomimetic nanoreactor Au/TiO2@RBC was fabricated for photothermal therapy by co-encapsulating photothermal agents and photocatalysts in red blood cell membranes.

scholarly journals Harnessing platelets as functional vectors for contrast enhanced ultrasound imaging and fluorescence imaging

RSC Advances ◽  
2019 ◽  
Vol 9 (72) ◽  
pp. 41993-41999
Author(s):  
Chuang Gao ◽  
Pravin Bhattarai ◽  
Yiming Zhou ◽  
Nisi Zhang ◽  
Sadaf Hameed ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Ultrasound Imaging ◽  
Blood Cells ◽  
Recent Progress ◽  
Cell Membranes ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

The recent progress in the development of highly biocompatible nanoplatforms mostly encompasses the use of biological excipients such as red blood cells, cancer cell membranes, and also platelets.

Characterization of β-Adrenergic Receptor Linked to Adenylate Cyclase in a Human Cancer Cell Line (COLO 16)

1978 ◽  
Vol 55 (1) ◽  
pp. 23-29
Author(s):  
T. J. Martin ◽  
S. R. Nahorski ◽  
N. H. Hunt ◽  
J. K. Dawborn ◽  
R. S. Loomes ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Cell Line ◽  
Cancer Cell ◽  
Adrenergic Receptor ◽  
Cell Membranes ◽  
Human Cancer ◽  
Specific Binding ◽  
Cancer Cell Line ◽  
Human Cancer Cell ◽  
Adrenergic Agonists

1. A human cancer cell line (COLO 16) derived originally from an epidermal squamous cell carcinoma was found to possess adenylate cyclase responsiveness to β-adrenergic agonists. 2. The adenylate cyclase response was characterized with respect to activation constants (KA) for various β-adrenergic agonists and inhibition constants (Ki) for antagonists. 3. Intact cells responded with dose-dependent increases in production of cyclic adenosine 3′:5′-monophosphate. 4. Properties of the β-adrenergic receptor were evaluated by using the specific binding of [3H]propranolol to cell membranes. Specific binding was saturable, with KD 5.79 nmol/l and binding sites 0.68 pmol/mg of protein. 5. Competition for binding to cell membranes was shown by β-adrenergic agonists and antagonists and was stereospecific. There was close agreement between the affinity of these various agents on adenylate cyclase and receptor binding. 6. It is likely that the β-adrenergic receptor-linked adenylate cyclase in COLO 16 cells represents persistence in a cancer cell line of a receptor present normally in epidermal cells.

scholarly journals Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation

2016 ◽  
Vol 17 (11) ◽  
pp. 1860 ◽  
Author(s):  
Sophie Béraud-Dufour ◽  
Christelle Devader ◽  
Fabienne Massa ◽  
Morgane Roulot ◽  
Thierry Coppola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Colorectal Cancer Cell ◽  
Soluble Form ◽  
Cell Dissociation ◽  
Neurotensin Receptor
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