Highly Efficient Multifunctional Organic Photosensitizer with Aggregation-Induced Emission for In Vivo Bioimaging and Photodynamic Therapy

2021 ◽  
Author(s):  
Yunhui Liao ◽  
Ruolan Wang ◽  
Shaozhen Wang ◽  
Yifan Xie ◽  
Huanhao Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aggregation Induced Emission ◽  
Highly Efficient

Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics

2018 ◽  
Vol 30 (39) ◽  
pp. 1802105 ◽  
Author(s):  
Dong Wang ◽  
Michelle M. S. Lee ◽  
Guogang Shan ◽  
Ryan T. K. Kwok ◽  
Jacky W. Y. Lam ◽  
...  
Keyword(s):  
Near Infrared ◽  
Aggregation Induced Emission ◽  
Highly Efficient ◽  
Cancer Theranostics

scholarly journals Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo

2017 ◽  
Vol 53 (15) ◽  
pp. 2339-2342 ◽  
Author(s):  
Li Yan ◽  
Zhigang Wang ◽  
Xianfeng Chen ◽  
Xiao-Jun Gou ◽  
Zhenyu Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polyethylene Glycol ◽  
Layered Double Hydroxide ◽  
Layered Double Hydroxides ◽  
Chlorin E6 ◽  
Therapeutic Efficiency ◽  
Highly Efficient ◽  
Double Hydroxide ◽  
Double Hydroxides

We covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes with excellentin vivophotodynamic therapeutic efficiency and safety profiles.

scholarly journals Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Xiaoqing Yi ◽  
Jingjing Hu ◽  
Jun Dai ◽  
Xiaoding Lou ◽  
Zujin Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cellular Uptake ◽  
Continuous Light ◽  
Light Irradiation ◽  
Fluorescence Signal ◽  
Aggregation State ◽  
Aggregation Induced Emission ◽  
Dual Stage

<p>Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N<sub>3</sub>) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L<sub>1</sub>, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L<sub>2</sub>, 18 min) for sufficient ROS production, but also monitor the non-fluorescent drug PTX release in turn. Both <i>in vivo</i> and <i>in vitro</i> studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited superior therapeutic effect than only 24-min continuous light irradiation.<br></p>

scholarly journals Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

2008 ◽  
Vol 130 (32) ◽  
pp. 10643-10647 ◽  
Author(s):  
Yu Cheng ◽  
Anna C. Samia ◽  
Joseph D. Meyers ◽  
Irene Panagopoulos ◽  
Baowei Fei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Highly Efficient ◽  
Photodynamic Therapy Of Cancer

scholarly journals Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Xiaoqing Yi ◽  
Jingjing Hu ◽  
Jun Dai ◽  
Xiaoding Lou ◽  
Zujin Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cellular Uptake ◽  
Continuous Light ◽  
Light Irradiation ◽  
Fluorescence Signal ◽  
Aggregation State ◽  
Aggregation Induced Emission ◽  
Dual Stage

<p>Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N<sub>3</sub>) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L<sub>1</sub>, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L<sub>2</sub>, 18 min) for sufficient ROS production, but also monitor the non-fluorescent drug PTX release in turn. Both <i>in vivo</i> and <i>in vitro</i> studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited superior therapeutic effect than only 24-min continuous light irradiation.<br></p>

scholarly journals Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Xiaoqing Yi ◽  
Jingjing Hu ◽  
Dajung Jun ◽  
Xiaoding Lou ◽  
Zujin Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cellular Uptake ◽  
Continuous Light ◽  
Light Irradiation ◽  
Fluorescence Signal ◽  
Aggregation State ◽  
Aggregation Induced Emission ◽  
Dual Stage

<p>Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N<sub>3</sub>) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L<sub>1</sub>, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L<sub>2</sub>, 18 min) for sufficient ROS production, but also monitor the non-fluorescent drug PTX release in turn. Both <i>in vivo</i> and <i>in vitro</i> studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited superior therapeutic effect than only 24-min continuous light irradiation.<br></p>

Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles

Nano Research ◽  
2018 ◽  
Vol 11 (5) ◽  
pp. 2756-2770 ◽  
Author(s):  
Xianhe Sun ◽  
Abudureheman Zebibula ◽  
Xiaobiao Dong ◽  
Gonghui Li ◽  
Guanxin Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dual Function ◽  
Aggregation Induced Emission
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