scholarly journals Silica Encapsulation of Fluorescent Nanodiamonds for Colloidal Stability and Facile Surface Functionalization

2013 ◽  
Vol 135 (21) ◽  
pp. 7815-7818 ◽  
Author(s):  
Ambika Bumb ◽  
Susanta K. Sarkar ◽  
Neil Billington ◽  
Martin W. Brechbiel ◽  
Keir C. Neuman
Keyword(s):  
Surface Functionalization ◽  
Colloidal Stability ◽  
Fluorescent Nanodiamonds ◽  
Silica Encapsulation

Versatile Route to Colloidal Stability and Surface Functionalization of Hydrophobic Nanomaterials

Langmuir ◽  
2016 ◽  
Vol 32 (22) ◽  
pp. 5629-5636 ◽  
Author(s):  
Heidi R. Culver ◽  
Stephanie D. Steichen ◽  
Margarita Herrera-Alonso ◽  
Nicholas A. Peppas
Keyword(s):  
Surface Functionalization ◽  
Colloidal Stability

Surface Functionalization of Silica Nanoparticles Supports Colloidal Stability in Physiological Media and Facilitates Internalization in Cells

Langmuir ◽  
2012 ◽  
Vol 28 (20) ◽  
pp. 7598-7613 ◽  
Author(s):  
Christina Graf ◽  
Qi Gao ◽  
Irene Schütz ◽  
Christelle Njiki Noufele ◽  
Wentao Ruan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
In Cells

Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability

ACS Nano ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 6829-6842 ◽  
Author(s):  
Fiorenza Rancan ◽  
Qi Gao ◽  
Christina Graf ◽  
Stefan Troppens ◽  
Sabrina Hadam ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Amorphous Silica ◽  
Colloidal Stability ◽  
Skin Penetration ◽  
Variable Size

scholarly journals Surface Modification of Fluorescent Nanodiamonds for Biological Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 153
Author(s):  
Hak-Sung Jung ◽  
Keir C. Neuman
Keyword(s):  
Surface Modification ◽  
Surface Functionalization ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Cell Labeling ◽  
Great Promise ◽  
Biological Applications ◽  
Homogeneous Surface ◽  
New Class ◽  
Fluorescent Nanodiamonds

Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Implementation of these applications requires reliable and precise surface functionalization. Although diamonds are generally considered inert, they typically possess diverse surface groups that permit a range of different functionalization strategies. This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties. Furthermore, the subsequent coupling of biomolecules onto functionalized nanodiamonds is reviewed. Finally, biomedical applications of nanodiamonds are discussed in the context of functionalization.

scholarly journals Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

2020 ◽  
Author(s):  
Yinke Wu ◽  
Md Noor A Alam ◽  
Priyadharshini Balasubramanian ◽  
Pia Winterwerber ◽  
Anna Ermakova ◽  
...  
Keyword(s):  
Electrostatic Interactions ◽  
Colloidal Stability ◽  
Monomer Concentration ◽  
Biological Applications ◽  
Chemical Surface ◽  
Reactive Groups ◽  
Fluorescent Nanodiamonds ◽  
Nanoscale Sensing ◽  
Post Modification ◽  
The Impact

Fluorescent nanodiamonds (NDs) are carbon-based nanoparticles with various outstanding magneto-optical properties. After preparation, NDs have a variety of different surface groups that determine their physicochemical properties. For biological applications, surface modifications are crucial to impart a new interphase for controlled interactions with biomolecules or cells. Herein, a straight-forward synthesis concept denoted "adsorption-crosslinking" is applied for the efficient modification of NDs, which sequentially combines fast non-covalent adsorption based on electrostatic interactions and subsequent covalent cross-linking. As a result, a very thin and uniform nanogel coating surrounding the NDs is obtained, which imparts reactive groups as well as high colloidal stability. The impact of the reaction time, monomer concentration, molecular weight, and structure of the cross-linker on the resulting nanogel shell, the availability of reactive chemical surface functions and the quantum sensing properties of the coated NDs has been assessed and optimized. Post-modification of the nanogel-coated NDs was achieved with phototoxic ruthenium complexes yielding ND-based probes suitable for photodynamic applications. The adsorption-crosslinking ND functionalization reported herein provides new avenues towards functional probes and traceable nanocarriers for high resolution bioimaging, nanoscale sensing and photodynamic applications. <br>

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

2020 ◽  
Author(s):  
Yingke Wu ◽  
Md Noor A Alam ◽  
Priyadharshini Balasubramanian ◽  
Pia Winterwerber ◽  
Anna Ermakova ◽  
...  
Keyword(s):  
Electrostatic Interactions ◽  
Colloidal Stability ◽  
Monomer Concentration ◽  
Biological Applications ◽  
Chemical Surface ◽  
Reactive Groups ◽  
Fluorescent Nanodiamonds ◽  
Nanoscale Sensing ◽  
Post Modification ◽  
The Impact

Fluorescent nanodiamonds (NDs) are carbon-based nanoparticles with various outstanding magneto-optical properties. After preparation, NDs have a variety of different surface groups that determine their physicochemical properties. For biological applications, surface modifications are crucial to impart a new interphase for controlled interactions with biomolecules or cells. Herein, a straight-forward synthesis concept denoted "adsorption-crosslinking" is applied for the efficient modification of NDs, which sequentially combines fast non-covalent adsorption based on electrostatic interactions and subsequent covalent cross-linking. As a result, a very thin and uniform nanogel coating surrounding the NDs is obtained, which imparts reactive groups as well as high colloidal stability. The impact of the reaction time, monomer concentration, molecular weight, and structure of the cross-linker on the resulting nanogel shell, the availability of reactive chemical surface functions and the quantum sensing properties of the coated NDs has been assessed and optimized. Post-modification of the nanogel-coated NDs was achieved with phototoxic ruthenium complexes yielding ND-based probes suitable for photodynamic applications. The adsorption-crosslinking ND functionalization reported herein provides new avenues towards functional probes and traceable nanocarriers for high resolution bioimaging, nanoscale sensing and photodynamic applications. <br>

scholarly journals Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

2017 ◽  
Vol 18 (2) ◽  
pp. 483-489 ◽  
Author(s):  
Resham J. Banga ◽  
Sai Archana Krovi ◽  
Suguna P. Narayan ◽  
Anthony J. Sprangers ◽  
Guoliang Liu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Polymeric Nanoparticles ◽  
Spherical Nucleic Acids

Supramolecular-micelle-directed preparation of uniform magnetic nanofibers with length tunability, colloidal stability and capacity for surface functionalization

2021 ◽  
Vol 12 (13) ◽  
pp. 1924-1930
Author(s):  
Mingwei Tian ◽  
Chen Ma ◽  
Xiaoyu Huang ◽  
Guolin Lu ◽  
Chun Feng
Keyword(s):  
Surface Functionalization ◽  
Colloidal Stability ◽  
Morphological Stability ◽  
Magnetic Nanofibers

We report a versatile and efficient platform to prepare uniform magnetic nanofibers with length tunability, colloidal and morphological stability, capacity for surface functionalization and enhanced T2 contrast.

scholarly journals Synthesis of Phosphonic Acid Ligands for Nanocrystal Surface Functionalization and Solution Processed Memristors

2018 ◽  
Author(s):  
Jonathan De Roo ◽  
Zimu Zhou ◽  
Jiaying Wang ◽  
Loren Deblock ◽  
Alfred J. Crosby ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Phosphonic Acid ◽  
Flexible Electronics ◽  
Colloidal Stability ◽  
Operating Voltage ◽  
Conductive Atomic Force Microscopy ◽  
Phosphonic Acids ◽  
Force Microscopy ◽  
Atomic Force ◽  
Ligand Shell

<p>Here we synthesize 2-ethylhexyl, 2-hexyldecyl, 2-[2-(2-methoxyethoxy)ethoxy]ethyl, oleyl and <i>n</i>-octadecyl phosphonic acid and use them to functionalize CdSe and HfO<sub>2</sub> nanocrystals. In contrast to branched carboxylic acids, post-synthetic surface functionalization of CdSe and HfO<sub>2</sub> nanocrystals is readily achieved with branched phosphonic acids. A simple flow coating process is used to deposit ribbons of individual phosphonic acid capped HfO<sub>2</sub> nanocrystals, which are subsequently evaluated as a memristor using conductive atomic force microscopy (c-AFM). We find that 2-ethylhexyl phosphonic acid is a superior ligand, combining a high colloidal stability with a compact ligand shell that results in a record-low operating voltage that is promising for application in flexible electronics. </p>

scholarly journals The role of surface functionalization of silica nanoparticles for bioimaging

2016 ◽  
Vol 09 (04) ◽  
pp. 1630005 ◽  
Author(s):  
Maria C. Gomes ◽  
Ângela Cunha ◽  
Tito Trindade ◽  
João P. C. Tomé
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Organic Dyes ◽  
Inorganic Nanoparticles ◽  
Biological Applications ◽  
Crucial Aspect ◽  
Particle Properties ◽  
Cellular Recognition

Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.

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