THE MECHANISM OF FORMATION OF BETA-ARYL-BETA-AMINO FATTY ACIDS BY THE CONDENSATION OF AROMATIC ALDEHYDES WITH MALONIC ACID AND ITS DERIVATIVES1

1929 ◽  
Vol 51 (3) ◽  
pp. 841-847 ◽  
Author(s):  
W. M. Rodionow ◽  
E. A. Postovskaja
Keyword(s):  
Fatty Acids ◽  
Malonic Acid ◽  
Aromatic Aldehydes ◽  
Mechanism Of Formation

ChemInform Abstract: Stereoselective Synthesis of Dehydroamino Acids Using Malonic Acid Half Oxyester and Aromatic Aldehydes.

ChemInform ◽  
2016 ◽  
Vol 47 (34) ◽  
Author(s):  
Yuttapong Singjunla ◽  
Silvia Colombano ◽  
Jerome Baudoux ◽  
Jacques Rouden
Keyword(s):  
Malonic Acid ◽  
Stereoselective Synthesis ◽  
Aromatic Aldehydes ◽  
Dehydroamino Acids

scholarly journals Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives from Reaction of Malononitrile, Aldehyde and 2-Oxoglyoxalarylhydrazones in Q-Tubes

2017 ◽  
Author(s):  
Majdah A. AL-Johani ◽  
Khadijah M. Al-Zaydi ◽  
Sameera M. Mousally ◽  
Norah F. Alqahtani ◽  
Mohamed H. Elnagdi
Keyword(s):  
Crystal Structure ◽  
Reaction Pathway ◽  
Aromatic Aldehydes ◽  
Reaction Products ◽  
Mechanism Of Formation ◽  
X Ray ◽  
Alternate Pathway ◽  
Considerable Research ◽  
Increased Pressure ◽  
Chemical Evidence

The considerable biological and medicinal activities of pyridazines has stimulated considerable research on efficient syntheses of these derivatives. In the last decade, microwave irradiation has generally been used for the energy source. As demonstrated in recent studies, pressure reactor “Q-tubes” may be used to accelerate several of these reactions in a more optimal and safer manner (compared to microwaves). In these studies there has been postulated a pathway for the formation of pyridazino[5,4,3-de][1,6]naphthyridine derivatives . In this paper we consider this pathway, and an alternate pathway, for several reactions. Contrary to the suggestion in these studies the pathway in which initial dimerization of malononitrile was postulated could be excluded based on chemical evidence. The reactions performed were the reaction of arylhydrazonals 1a,b with benzylidinemalononitrile which afforded in Q-tube the 3-acyl-4-aryl-1-phenyl-6-amino-1,4-dihydropyridazines, and the reaction of arylhydrazonals 1a,b, malononitrile 9 and aromatic aldehydes 10a-g in Q-tubes which afforded the tricyclic systems 12a-n whose structure could be established by X-ray crystal structure determination. In conclusion, we have added to the work of the recent studies by excluding a reaction pathway for one of their reaction products.

IV.—An X-ray Examination of Saturated Dicarboxylic Acids and Amides of the Fatty Acid Series

1929 ◽  
Vol 48 ◽  
pp. 20-27 ◽  
Author(s):  
Edward Henderson
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Malonic Acid ◽  
Dicarboxylic Acids ◽  
X Rays ◽  
X Ray ◽  
Fatty Acid Amides

SummarySeveral additional members of the series of normal saturated dicarboxylic acids have been investigated by X-rays, and the results are in agreement with the conclusions arrived at in an earlier paper. In the series of mono- and di-alkyl malonic acids, successive reflection planes are separated by the length of one molecule. The series of fatty acid amides closely resembles that of the fatty acids themselves. The cleavage planes are separated by the length of two molecules oriented in opposite directions.My thanks are due to Mr N. K. Adam for the specimens of mono- and dioctadecyl malonic acid, and to Sir James Walker for his advice and helpful criticism.

STIMULATION OF LIPOGENESIS IN BIOTIN-DEFICIENT CHICKS BY DIETARY MALONIC ACID

1967 ◽  
Vol 45 (6) ◽  
pp. 873-879 ◽  
Author(s):  
William E. Donaldson
Keyword(s):  
Fatty Acids ◽  
Malonic Acid ◽  
Dietary Fat ◽  
Biotin Deficiency ◽  
Stimulation Of

Experiments were conducted to examine possible mechanisms of dietary malonic acid stimulation of lipogenesis in biotin-deficient intact chicks. Both dietary fat and biotin deficiency reduced incorporation of acetate-14C into carcass fatty acids. Dietary malonic acid reduced acetate-14C incorporation into fatty acids by control chicks and did not restore incorporation to control levels in fat-fed and biotin-deficient chicks. The patterns of incorporation of succinate-14C and aspartate-14C were similar to the pattern of acetate-14C incorporation. Biotin deficiency did not reduce incorporation of orally administered malonate-14C into carcass fatty acids as compared with control incorporation. When unlabeled malonate was fed to biotin-deficient chicks, the percentage incorporation of malonate-14C into fatty acids was not reduced. The results suggest that dietary malonic acid is incorporated into carcass fatty acids in sufficient quantity to partially overcome inhibition of lipogenesis by biotin deficiency.

Sign in / Sign up

Export Citation Format

Share Document