Additions and Corrections - The Influence of a Quarternary Ammonium Group on the Hydrogen Atoms of an Adjacent Methylene Group

1965 ◽  
Vol 87 (24) ◽  
pp. 5809-5809
Author(s):  
Arnold Jackson ◽  
C. Marvel
Keyword(s):  
Hydrogen Atoms ◽  
Ammonium Group ◽  
Methylene Group ◽  
Adjacent Methylene

Investigation of the mobility of methylene group hydrogen atoms in some derivatives of 2-iminothiazolidin-4-one

1967 ◽  
Vol 3 (2) ◽  
pp. 516-518
Author(s):  
I. I. Chizhevskaya ◽  
R. S. Kharchenko ◽  
N. N. Khovratovich
Keyword(s):  
Hydrogen Atoms ◽  
Derivatives Of ◽  
Methylene Group

ChemInform Abstract: ON THE MOBILITY OF THE HYDROGEN ATOMS OF THE METHYLENE GROUP IN SOME ACYLPSEUDOTHIOHYDANTOINS

1975 ◽  
Vol 6 (43) ◽  
pp. no-no
Author(s):  
A. A. TSURKAN ◽  
A. I. FROLOVA ◽  
N. I. POSPELOV ◽  
L. A. DOROFEEVA
Keyword(s):  
Hydrogen Atoms ◽  
Methylene Group

Mobility of hydrogen atoms of the methylene group of certain acylpseudothiohydantoins

1975 ◽  
Vol 9 (6) ◽  
pp. 363-366 ◽  
Author(s):  
A. A. Tsurkan ◽  
A. I. Frolova ◽  
N. I. Pospelov ◽  
L. A. Dorofeeva
Keyword(s):  
Hydrogen Atoms ◽  
Methylene Group

scholarly journals Dihydroceramide Desaturase Inhibition by a Cyclopropanated Dihydroceramide Analog in Cultured Keratinocytes

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Susanne Brodesser ◽  
Thomas Kolter
Keyword(s):  
Double Bond ◽  
Chemical Synthesis ◽  
Cultured Cells ◽  
Hydrogen Atoms ◽  
Differentiation Markers ◽  
Cultured Keratinocytes ◽  
Proliferation And Differentiation ◽  
Dihydroceramide Desaturase ◽  
Methylene Group

Most mammalian sphingolipids contain a 4,5-(E)-double bond. We report on the chemical synthesis of a dihydroceramide derivative that prevents the introduction of the double bond into sphingolipids. Minimal alteration of the parent structure by formally replacing the hydrogen atoms in the 5- and in the 6-position of the sphinganine backbone by a methylene group leads to an inhibitor of dihydroceramide desaturase in cultured cells. In the presence of 10–50 μM of compound (1), levels of biosynthetically formed dihydroceramide and—surprisingly—also of phytoceramide are elevated at the expense of ceramide. The cells respond to the lack of unsaturated sphingolipids by an elevation of mRNAs of enzymes required for sphingosine formation. At the same time, the analysis of proliferation and differentiation markers indicates that the sphingolipid double bond is required to keep the cells in a differentiated state.

scholarly journals Crystal structure of ipratropium bromide monohydrate, C20H30NO3Br(H2O)

2020 ◽  
Vol 35 (1) ◽  
pp. 61-66
Author(s):  
Shivang Bhaskar ◽  
Joseph T. Golab ◽  
James A. Kaduk ◽  
Amy M. Gindhart ◽  
Thomas N. Blanton
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Water Molecule ◽  
Powder Diffraction ◽  
Density Functional ◽  
Ipratropium Bromide ◽  
Hydroxyl Group ◽  
Methyl Groups ◽  
Hydrogen Atoms ◽  
Methylene Group

The crystal structure of ipratropium bromide monohydrate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Ipratropium bromide monohydrate crystallizes in the space group P21/c (#14) with a = 8.21420(7) Å, b = 10.54617(13) Å, c = 24.0761(39) Å, β = 99.9063(7) °, V = 2054.574(22) Å3, and Z = 4. Both hydrogen atoms of the water molecule act as donors to the bromide cation, forming a ring with the graph set R2,4(8). The hydroxyl group also acts as a donor to Br. Several C–H⋯Br hydrogen bonds are present. The water molecule acts as an acceptor in two C–H⋯O hydrogen bonds from methyl groups. The ketone acts as an acceptor in C–H⋯O hydrogen bonds from methyl groups, a methylene group, and a methyne group. The hydroxyl group acts as an acceptor in a C–H⋯O hydrogen bond from a phenyl carbon atom. The powder pattern is included in the Powder Diffraction File™ as entry 00-066-1611.

scholarly journals Crystal structure of 2′-[(2′,4′-difluorobiphenyl-4-yl)carbonyl]-1′-phenyl-1′,2′,5′,6′,7′,7a'-hexahydrospiro[indole-3,3′-pyrrolizin]-2(1H)-one

2015 ◽  
Vol 71 (8) ◽  
pp. 915-918 ◽  
Author(s):  
M. Fathimunnisa ◽  
H. Manikandan ◽  
S. Selvanayagam ◽  
B. Sridhar
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bond ◽  
Crystal Packing ◽  
Site Occupancy ◽  
Chain Structure ◽  
Π Interactions ◽  
Envelope Conformation ◽  
Methylene Groups ◽  
Methylene Group ◽  
Adjacent Methylene

In the title pyrrolizidine derivative, C33H26F2N2O2, both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The difluorophenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H...O hydrogen bond, which forms anR22(8) motif, and a C—H...O interaction, which generates aC(8) chain along [010]. In addition, this chain structure is stabilized by C—H...π interactions. In one of the pyrrolidine rings, the methylene group forming the flap of an envelope and the H atoms of the adjacent methylene groups are disordered over two sets of sites, with site-occupancy factors of 0.571 (4) and 0.429 (4)

scholarly journals Anhydrous Aluminum Chloride Catalyzed Methylene Group Inclusion: Mechanistic, Spectral and Single Crystal X-Ray Structural Study on Methanediyl Bis(Cyclohexylmethylcarbamodithioate)

2016 ◽  
Vol 68 ◽  
pp. 61-70
Author(s):  
K. Ramalingam ◽  
C. Rizzoli ◽  
G.S. Sivagurunathan ◽  
S. Sivasekar ◽  
T. Rajaraman ◽  
...  
Keyword(s):  
Single Crystal ◽  
Supramolecular Interactions ◽  
Methylene Proton ◽  
Hydrogen Atoms ◽  
Methylene Carbon ◽  
Nmr Spectrum ◽  
Spectral Techniques ◽  
X Ray ◽  
Mechanistic Pathway ◽  
Methylene Group

In this study anhydrous AlCl3is used as a catalyst for the inclusion of a methylene group in to cyclohexylmethyldithiocarbamic acid to form methanediyl bis(cyclohexylmethylcarbamodithioate). Dichloromethane is used as a methylene group bearer in the reaction. A suitable mechanistic pathway involving+CH2Cl is discussed. FTIR, NMR and Mass spectral techniques have been used in the analysis. Single crystal X-ray structure of the compound was determined. FTIR spectrum of the compound showed υc-sband at 1073 cm-1and υC-Hvibrations appeared at 2853 and 2928 cm-1. Thioureide stretching band was observed at 1473 cm-1. The molecular ion peak in the Mass spectroscopy confirmed the proposed formula. H1NMR spectrum of the compound showed a signal at 4.33(s) ppm for α-CH of the cyclohexyl ring and -CH3protonsattached to nitrogen appeared at 3.40 ppm. Methylene proton (S-CH2-S) signal appeared at 3.16 ppm which is largely deshielded by the presence of two electronegative sulphur atoms on either side. The characteristic methylene carbon (S-CH2-S) signal appeared at 45.46 ppm in the13C NMR spectrum. Single crystal X-ray structural analysis of the compound showed it to be monomeric. Methylene carbon in S-CH2-S, C(9) is tetrahedrally bonded to two hydrogen atoms and two sulphur atoms S(2), S(3). The molecule stacks its cyclohexyl rings along ‘c’ axis of the unit cell. Short contacts in the form of supramolecular interactions such as C---S and S---S exist in the solid state at 3.49 and 3.50 Å respectively.

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