Synthesis of Novel Analogs of Acetyl Coenzyme A: Mimics of Enzyme Reaction Intermediates

1994 ◽  
Vol 116 (11) ◽  
pp. 4660-4668 ◽  
Author(s):  
David P. Martin ◽  
Richard T. Bibart ◽  
Dale G. Drueckhammer
Keyword(s):  
Coenzyme A ◽  
Enzyme Reaction ◽  
Reaction Intermediates ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

scholarly journals Acetyl Coenzyme A Carboxylase

1969 ◽  
Vol 244 (22) ◽  
pp. 6254-6262 ◽  
Author(s):  
Philip W. Majerus ◽  
Elisabeth Kilburn
Keyword(s):  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Acetyl Coenzyme A Carboxylase

scholarly journals Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases

2021 ◽  
Vol 22 (2) ◽  
pp. 764
Author(s):  
Russel J. Reiter ◽  
Ramaswamy Sharma ◽  
Sergio Rosales-Corral
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Warburg Effect ◽  
Coenzyme A ◽  
Aerobic Glycolysis ◽  
Pyruvate Dehydrogenase Complex ◽  
Pyruvate Dehydrogenase Kinase ◽  
Metabolic Phenotype ◽  
Common Denominator ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

Glucose is an essential nutrient for every cell but its metabolic fate depends on cellular phenotype. Normally, the product of cytosolic glycolysis, pyruvate, is transported into mitochondria and irreversibly converted to acetyl coenzyme A by pyruvate dehydrogenase complex (PDC). In some pathological cells, however, pyruvate transport into the mitochondria is blocked due to the inhibition of PDC by pyruvate dehydrogenase kinase. This altered metabolism is referred to as aerobic glycolysis (Warburg effect) and is common in solid tumors and in other pathological cells. Switching from mitochondrial oxidative phosphorylation to aerobic glycolysis provides diseased cells with advantages because of the rapid production of ATP and the activation of pentose phosphate pathway (PPP) which provides nucleotides required for elevated cellular metabolism. Molecules, called glycolytics, inhibit aerobic glycolysis and convert cells to a healthier phenotype. Glycolytics often function by inhibiting hypoxia-inducible factor-1α leading to PDC disinhibition allowing for intramitochondrial conversion of pyruvate into acetyl coenzyme A. Melatonin is a glycolytic which converts diseased cells to the healthier phenotype. Herein we propose that melatonin’s function as a glycolytic explains its actions in inhibiting a variety of diseases. Thus, the common denominator is melatonin’s action in switching the metabolic phenotype of cells.

scholarly journals Activation of pineal acetyl coenzyme A hydrolase by disulfide peptides.

1982 ◽  
Vol 257 (17) ◽  
pp. 10030-10032
Author(s):  
M A Namboodiri ◽  
J T Favilla ◽  
D C Klein
Keyword(s):  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

scholarly journals Acetyl-Coenzyme A: Arylamine N-Acetyltransferase

1971 ◽  
Vol 246 (10) ◽  
pp. 3250-3258
Author(s):  
Barbara Riddle ◽  
William P. Jencks
Keyword(s):  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme
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