Structure and Photochemistry of Dicyanocobalt(III) Tetraphenylporphyrin. Photochromic Reaction Caused by Photodissociation of Axial Ligand

2000 ◽  
Vol 39 (21) ◽  
pp. 4850-4857 ◽  
Author(s):  
Mikio Hoshino ◽  
Hirotaka Sonoki ◽  
Yoshio Miyazaki ◽  
Yasuhiro Iimura ◽  
Kiyoko Yamamoto
Keyword(s):  
Axial Ligand ◽  
Photochromic Reaction

Development of 96 Multiple Injection-GC-MS Technique and Its Application in Protein Engineering of Natural and Non-Natural Enzymatic Reactions

2019 ◽  
Author(s):  
Anja Knorrscheidt ◽  
Pascal Püllmann ◽  
Eugen Schell ◽  
Dominik Homann ◽  
Erik Freier ◽  
...  
Keyword(s):  
Microtiter Plate ◽  
Axial Ligand ◽  
Cell System ◽  
Enzymatic Reactions ◽  
The Novel ◽  
Internal Standards ◽  
E Coli ◽  
Enzyme Screening ◽  
Plate Analysis ◽  
Microtiter Plate Analysis

Directed evolution requires the screening of enzyme libraries in biological matrices. Available assays are mostly substrate or enzyme specific. Chromatographic techniques like LC and GC overcome this limitation, but require long analysis times. The herein developed multiple injections in a single experimental run (MISER) using GC coupled to MS allows the injection of samples every 33 s resulting in 96-well microtiter plate analysis within 50 min. This technique is implementable in any GC-MS system with autosampling. Since the GC-MS is far less prone to ion suppression than LCMS, no chromatographic separation is required. This allows the utilisation of an internal standards and the detection of main and side-product. To prove the feasibility of the system in enzyme screening, two libraries were assessed: i) YfeX library in an E. coli whole cell system for the carbene-transfer reaction on indole revealing the novel axial ligand tryptophan, ii) a library of 616 chimeras of fungal unspecific peroxygenase (UPO) in S. cerevisiae supernatant for hydroxylation of tetralin resulting in novel constructs. The data quality and representation are automatically assessed by a new R-script.

Antimicrobial Potential of Benzimidazole Derived Molecules

2019 ◽  
Vol 19 (8) ◽  
pp. 624-646 ◽  
Author(s):  
Yogita Bansal ◽  
Manjinder Kaur ◽  
Gulshan Bansal
Keyword(s):  
Biological Activities ◽  
Benzimidazole Derivative ◽  
Structural Similarity ◽  
Living System ◽  
Axial Ligand ◽  
Benzimidazole Derivatives ◽  
Research Groups ◽  
Structural Resemblance ◽  
Privileged Structure ◽  
Anti Hiv

Structural resemblance of benzimidazole nucleus with purine nucleus in nucleotides makes benzimidazole derivatives attractive ligands to interact with biopolymers of a living system. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. This structural similarity prompted medicinal chemists across the globe to synthesize a variety of benzimidazole derivatives and to screen those for various biological activities, such as anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimicrobial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant and antidiabetic activities. Hence, benzimidazole nucleus is considered as a privileged structure in drug discovery, and it is exploited by many research groups to develop numerous compounds that are purported to be antimicrobial. Despite a large volume of research in this area, no novel benzimidazole derived compound has emerged as clinically effective antimicrobial drug. In the present review, we have compiled various reports on benzimidazole derived antimicrobials, classified as monosubstituted, disubstituted, trisubstituted and tetrasubstituted benzimidazoles, bisbenzimidazoles, fused-benzimidazoles, and benzimidazole derivative-metal complexes. The purpose is to collate these research reports, and to generate a generalised outlay of benzimidazole derived molecules that can assist the medicinal chemists in selecting appropriate combination of substituents around the nucleus for designing potent antimicrobials.

Voltammetric Studies of Some Novel Fe(III) Complexes with Quadridentate Ligands. The Axial Ligand-Exchange Reactions in DMF and DMSO

1995 ◽  
Vol 60 (7) ◽  
pp. 1140-1157 ◽  
Author(s):  
Ljiljana S. Jovanovic ◽  
Luka J. Bjelica
Keyword(s):  
Oxidation State ◽  
Chemical Reactions ◽  
Ligand Exchange ◽  
Kinetic Data ◽  
Central Atom ◽  
Axial Ligand ◽  
Exchange Reactions ◽  
Ligand Effect ◽  
Condensation Products ◽  
Voltammetric Studies

The electrochemistry of four novel Fe(III) complexes of the type [Fe(L)Cl], involving quadridentate ligands based on the condensation products of benzoylacetone-S-methylisothiosemicarbazone with salicylaldehyde, 5-chlorosalicylaldehyde, 3,5-dichlorosalicylaldehyde or 5-nitrosalicylaldehyde, was studied in DMF and DMSO at a GC electrode. All complexes undergo a two-step one-electron reductions, usually complicated by chemical reactions. In solutions containing Cl-, the ligand-exchange reactions Cl--DMF and Cl--DMSO take place. Stability of the chloride-containing complexes was discussed in terms of the coordinated ligand effect, oxidation state of the central atom and, in particular, of the donor effect of the solvent. Some relevant kinetic data were calculated.

pH Changes That Induce an Axial Ligand Effect on Nonheme Iron(IV) Oxo Complexes with an Appended Aminopropyl Functionality

2021 ◽  
Author(s):  
Reza Latifi ◽  
Taryn D. Palluccio ◽  
Wanhua Ye ◽  
Jennifer L. Minnick ◽  
Kwame S. Glinton ◽  
...  
Keyword(s):  
Axial Ligand ◽  
Nonheme Iron ◽  
Ligand Effect ◽  
Ph Changes ◽  
Oxo Complexes

scholarly journals Setting an Upper Limit on the Myoglobin Iron(IV)Hydroxide pKa: Insight into Axial Ligand Tuning in Heme Protein Catalysis

2014 ◽  
Vol 136 (25) ◽  
pp. 9124-9131 ◽  
Author(s):  
Timothy H. Yosca ◽  
Rachel K. Behan ◽  
Courtney M. Krest ◽  
Elizabeth L. Onderko ◽  
Matthew C. Langston ◽  
...  
Keyword(s):  
Heme Protein ◽  
Axial Ligand ◽  
Upper Limit ◽  
Insight Into ◽  
Protein Catalysis

Role of the axial ligand in hemeCO backbonding; DFT analysis of vibrational data

2000 ◽  
Vol 297 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Kathleen M. Vogel ◽  
Pawel M. Kozlowski ◽  
Marek Z. Zgierski ◽  
Thomas G. Spiro
Keyword(s):  
Axial Ligand

Axial ligand substitution reactions of iron(II) phthalocyanine adducts

1980 ◽  
Vol 19 (7) ◽  
pp. 2162-2165 ◽  
Author(s):  
Jens Martinsen ◽  
Michael Miller ◽  
Daria Trojan ◽  
D. A. Sweigart
Keyword(s):  
Ligand Substitution ◽  
Axial Ligand ◽  
Substitution Reactions ◽  
Ligand Substitution Reactions
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