scholarly journals Role of Desolvation in Thermodynamics and Kinetics of Ligand Binding to a Kinase

2014 ◽  
Vol 10 (12) ◽  
pp. 5696-5705 ◽  
Author(s):  
Jagannath Mondal ◽  
Richard A. Friesner ◽  
B. J. Berne
Keyword(s):  
Ligand Binding ◽  
Thermodynamics And Kinetics ◽  
Kinetics Of

scholarly journals Role of Desolvation in Thermodynamics and Kinetics of Ligand Binding to a Protein

2015 ◽  
Vol 108 (2) ◽  
pp. 12a
Author(s):  
Jagannath Mondal ◽  
Richard Friesner ◽  
Bruce J. Berne
Keyword(s):  
Ligand Binding ◽  
Thermodynamics And Kinetics ◽  
Kinetics Of

Structural evolution in lead substituted Bi–Sr–Ca–Cu–O superconductors

1991 ◽  
Vol 6 (2) ◽  
pp. 278-288 ◽  
Author(s):  
R. Ramesh ◽  
K. Remschnig ◽  
J.M. Tarascon ◽  
S.M. Green
Keyword(s):  
Structural Evolution ◽  
Homogeneous Sample ◽  
X Ray ◽  
Thermodynamics And Kinetics ◽  
Transmission Electron ◽  
Incommensurate Modulation ◽  
Kinetics Of ◽  
Pb Substitution ◽  
Microstructural Homogeneity

The structural evolution and cationic stoichiometry of Bi(Pb)–Sr–Ca–Cu–O superconductors have been studied using transmission electron microscopy and x-ray microanalysis. The nature of the incommensurate modulation changes systematically as increasing amounts of lead are added. X-ray microanalysis studies reveal that lead replaces Bi in the structure. Pb addition improves the microstructural homogeneity leading to the formation of a nearly homogeneous sample consisting of the “2223” phase. Based upon all the experimental results, it is inferred that the role of Pb substitution is related to the thermodynamics and kinetics of the formation of the n = 3 phase.

scholarly journals Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus

FEBS Letters ◽  
2000 ◽  
Vol 472 (2-3) ◽  
pp. 312-316 ◽  
Author(s):  
Johan Nord ◽  
Martin Kiefer ◽  
Hans-Werner Adolph ◽  
Michael M. Zeppezauer ◽  
Per-Olof Nyman
Keyword(s):  
Ligand Binding ◽  
Equine Infectious Anemia Virus ◽  
Transient Kinetics ◽  
C Terminus ◽  
Equine Infectious Anemia ◽  
Anemia Virus ◽  
Kinetics Of

Role of Solvents on the Thermodynamics and Kinetics of Forming Frustrated Lewis Pairs

2012 ◽  
Vol 3 (22) ◽  
pp. 3312-3319 ◽  
Author(s):  
Liem X. Dang ◽  
Gregory K. Schenter ◽  
Tsun-Mei Chang ◽  
Shawn M. Kathmann ◽  
Tom Autrey
Keyword(s):  
Frustrated Lewis Pairs ◽  
Thermodynamics And Kinetics ◽  
Kinetics Of ◽  
Lewis Pairs

Precipitation of Microalloy Carbo-Nitrides Prior, during and after γ/α Transformation

2005 ◽  
Vol 500-501 ◽  
pp. 75-86 ◽  
Author(s):  
Stanislaw Zajac
Keyword(s):  
Grain Refinement ◽  
Acicular Ferrite ◽  
Driving Force ◽  
Polygonal Ferrite ◽  
Precipitation Strengthening ◽  
Strengthening Mechanisms ◽  
Thermodynamics And Kinetics ◽  
Bainitic Steels ◽  
Kinetics Of

A brief summary is given of the desired effects of precipitation of microalloy nitrides and carbides in austenite and ferrite prior, during and after g−a transformation. Precipitation of microalloy compounds of Nb(C,N), TiC and V(C,N) is discussed in relation to several grain refinement and precipitation strengthening mechanisms. An improved understanding of the thermodynamics and kinetics of precipitation and phase transformations is presented using the approach based on the chemical driving force. Nucleation of intragranular polygonal ferrite on VN particles that grow in austenite and the formation of acicular ferrite inside the austenitic grains in Vsteels is described. The role of carbon in increasing the driving force for nucleation is elucidated and the benefits of using microalloy carbo-nitrides for precipitation strengthening of bainitic steels are reviewed. An expanded view on the role of microalloy carbo-nitrides in grain refinement and precipitation strengthening is presented.

scholarly journals Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae

2016 ◽  
Vol 113 (31) ◽  
pp. E4476-E4485 ◽  
Author(s):  
Camilla Rydström Lundin ◽  
Christoph von Ballmoos ◽  
Martin Ott ◽  
Pia Ädelroth ◽  
Peter Brzezinski
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Electron Transfer ◽  
Ligand Binding ◽  
Structural Changes ◽  
Regulatory Mechanism ◽  
Supramolecular Interactions ◽  
Wild Type ◽  
Single Turnover ◽  
Kinetics Of

The respiratory supercomplex factors (Rcf) 1 and 2 mediate supramolecular interactions between mitochondrial complexes III (ubiquinol-cytochrome c reductase; cyt. bc1) and IV (cytochrome c oxidase; CytcO). In addition, removal of these polypeptides results in decreased activity of CytcO, but not of cyt. bc1. In the present study, we have investigated the kinetics of ligand binding, the single-turnover reaction of CytcO with O2, and the linked cyt. bc1-CytcO quinol oxidation-oxygen-reduction activities in mitochondria in which Rcf1 or Rcf2 were removed genetically (strains rcf1Δ and rcf2Δ, respectively). The data show that in the rcf1Δ and rcf2Δ strains, in a significant fraction of the population, ligand binding occurs over a time scale that is ∼100-fold faster (τ ≅ 100 μs) than observed with the wild-type mitochondria (τ ≅ 10 ms), indicating structural changes. This effect is specific to removal of Rcf and not dissociation of the cyt. bc1–CytcO supercomplex. Furthermore, in the rcf1Δ and rcf2Δ strains, the single-turnover reaction of CytcO with O2 was incomplete. This observation indicates that the lower activity of CytcO is caused by a fraction of inactive CytcO rather than decreased CytcO activity of the entire population. Furthermore, the data suggest that the Rcf1 polypeptide mediates formation of an electron-transfer bridge from cyt. bc1 to CytcO via a tightly bound cyt. c. We discuss the significance of the proposed regulatory mechanism of Rcf1 and Rcf2 in the context of supramolecular interactions between cyt. bc1 and CytcO.

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