scholarly journals The role of pH on the thermodynamics and kinetics of muscle biochemistry: An in vivo study by 31P-MRS in patients with myo-phosphorylase deficiency

2011 ◽  
Vol 1807 (9) ◽  
pp. 1244-1249 ◽  
Author(s):  
E. Malucelli ◽  
S. Iotti ◽  
D.N. Manners ◽  
C. Testa ◽  
A. Martinuzzi ◽  
...  
Keyword(s):  
In Vivo Study ◽  
Thermodynamics And Kinetics ◽  
31P Mrs ◽  
Muscle Biochemistry ◽  
Kinetics Of

scholarly journals Role of vascular endothelial growth factor in inducing production of angiopoetin-1 – in vivo study in Fisher rats

2017 ◽  
Vol 68 (4) ◽  
pp. 326-329
Author(s):  
Piotr Barć ◽  
Tomasz Płonek ◽  
Dagmara Baczyńska ◽  
Artur Pupka ◽  
Wojciech Witkiewicz ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
In Vivo Study ◽  
Vascular Endothelial ◽  
Angiopoetin 1 ◽  
Endothelial Growth Factor

The role of quantitation of real-time 3-dimensional contrast-enhanced ultrasound in detecting microvascular invasion: an in vivo study

2016 ◽  
Vol 41 (10) ◽  
pp. 1973-1979 ◽  
Author(s):  
Zhu Wang ◽  
Wei Wang ◽  
Guang-Jian Liu ◽  
Zheng Yang ◽  
Li-Da Chen ◽  
...  
Keyword(s):  
Real Time ◽  
Microvascular Invasion ◽  
In Vivo Study ◽  
Contrast Enhanced Ultrasound ◽  
3 Dimensional ◽  
Contrast Enhanced

Structural evolution in lead substituted Bi–Sr–Ca–Cu–O superconductors

1991 ◽  
Vol 6 (2) ◽  
pp. 278-288 ◽  
Author(s):  
R. Ramesh ◽  
K. Remschnig ◽  
J.M. Tarascon ◽  
S.M. Green
Keyword(s):  
Structural Evolution ◽  
Homogeneous Sample ◽  
X Ray ◽  
Thermodynamics And Kinetics ◽  
Transmission Electron ◽  
Incommensurate Modulation ◽  
Kinetics Of ◽  
Pb Substitution ◽  
Microstructural Homogeneity

The structural evolution and cationic stoichiometry of Bi(Pb)–Sr–Ca–Cu–O superconductors have been studied using transmission electron microscopy and x-ray microanalysis. The nature of the incommensurate modulation changes systematically as increasing amounts of lead are added. X-ray microanalysis studies reveal that lead replaces Bi in the structure. Pb addition improves the microstructural homogeneity leading to the formation of a nearly homogeneous sample consisting of the “2223” phase. Based upon all the experimental results, it is inferred that the role of Pb substitution is related to the thermodynamics and kinetics of the formation of the n = 3 phase.

scholarly journals Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice

2020 ◽  
Author(s):  
Maximilian G. Decker ◽  
Cita Nottmeier ◽  
Julia Luther ◽  
Anke Baranowsky ◽  
Bärbel Kahl-Nieke ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
In Vivo Study

Role of Solvents on the Thermodynamics and Kinetics of Forming Frustrated Lewis Pairs

2012 ◽  
Vol 3 (22) ◽  
pp. 3312-3319 ◽  
Author(s):  
Liem X. Dang ◽  
Gregory K. Schenter ◽  
Tsun-Mei Chang ◽  
Shawn M. Kathmann ◽  
Tom Autrey
Keyword(s):  
Frustrated Lewis Pairs ◽  
Thermodynamics And Kinetics ◽  
Kinetics Of ◽  
Lewis Pairs

Role of Vitamin D3 as a Sensitizer to Cryoablation in a Murine Prostate Cancer Model: Preliminary In Vivo Study

Urology ◽  
2010 ◽  
Vol 76 (3) ◽  
pp. 764.e14-764.e20 ◽  
Author(s):  
Masaki Kimura ◽  
Zahid Rabbani ◽  
Vladimir Mouraviev ◽  
Matvey Tsivian ◽  
Jorge Caso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D3 ◽  
In Vivo Study ◽  
Cancer Model ◽  
Prostate Cancer Model

Endobrevin/VAMP-8-Mediated Dense Granule Release Is Required for Efficient Thrombus Formation in Vivo.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1836-1836
Author(s):  
Price S. Blair ◽  
Qiansheng Ren ◽  
Gwenda J. Graham ◽  
James R. Dilks ◽  
Sidney W. Whiteheart ◽  
...  
Keyword(s):  
Vascular Injury ◽  
Thrombus Formation ◽  
Dense Granule ◽  
Wild Type ◽  
Platelet Accumulation ◽  
Induced Aggregation ◽  
Kinetics Of ◽  
Granule Release

Abstract Individuals whose platelets lack dense core or alpha-granules suffer varying degrees of abnormal bleeding, implying that granule cargo contributes to hemostasis. Despite these clinical observations, little is known regarding the effects of impaired platelet granule secretion on thrombus formation in vivo. The release of cargo from platelet granules requires a group of membrane proteins called SNAREs (Soluble NSF Attachment Protein Receptors) that mediate fusion of granule membranes to the plasma membrane and open canalicular system. Endobrevin/VAMP-8 is the primary vesicular-SNARE (v-SNARE) responsible for efficient release of dense core and a-granule contents. To evaluate the importance of VAMP-8-mediated secretion on the kinetics of thrombus formation in vivo, we measured platelet accumulation following laser-induced vascular injury in VAMP-8−/− mice. Three different phases of thrombus formation - initiation, maximal accumulation, and stabilized platelet accumulation - were tested. Analysis of initial thrombus formation from wild-type and VAMP-8−/− mice showed that average platelet accumulation in VAMP- 8−/− mice was 23% of accumulation in wild-type mice (P=0.009) at 30 sec following injury. There was a trend towards smaller maximal thrombus size in VAMP-8−/− mice, but the difference was not statistically significant (P=0.1). Average stabilized platelet accumulation at 180 sec in VAMP-8−/− mice was 40% of wild-type mice (P=0.05). Thus, thrombus formation is delayed and decreased in VAMP-8−/− mice, but not absent. Dense granule release occurs more rapidly than alpha-granule release, which does not occur for 2–3 min following laser-induced vascular injury. Agonist-induced dense granule release from VAMP-8−/− platelets is defective. To directly evaluate the role of dense granule release on the kinetics of thrombus formation, we assessed thrombus formation in the mouse model of Hermansky-Pudlak syndrome, ruby-eye, which lack dense granules. Thrombus formation following laser-induced vascular injury was nearly abolished in ruby-eye mice such that maximal platelet accumulation was 15% that of wild-type mice. In vitro, the thrombin doses required to induce irreversible aggregation in wild-type, VAMP-8−/−, and ruby-eye platelets were 25 mU, 50 mU, and 150 mU, respectively. Incubation with apyrase had little effect on thrombin-induced aggregation of VAMP-8−/− or ruby-eye platelets. In contrast, incubation of wild-type platelets with apyrase reduced their thrombin sensitivity compared to that of ruby-eye platelets. Supplementation with a substimulatory ADP concentration reversed the thrombin-induced aggregation defect in VAMP-8−/− and ruby-eye mice. Thus, defective ADP release is the primary abnormality leading to impaired aggregation in VAMP-8−/− and ruby-eye mice. Tail bleeding times were assessed in VAMP- 8−/− mice to evaluate the role of VAMP-8 in hemostasis. In contrast to ruby-eye mice, which have a markedly prolonged bleeding time, tail bleeding times in VAMP-8−/− mice were not significantly prolonged compared to those in wild-type mice. These results demonstrate the importance of VAMP-8 and dense granule release in the initial phases of thrombus formation and validate the distal platelet secretory machinery as a potential target for anti-platelet therapies.

Role of Calcium Ion Antagonists of the Bladder Detrusor Muscle: In Vitro and in Vivo Study

1986 ◽  
Vol 135 (6) ◽  
pp. 1327-1331 ◽  
Author(s):  
M. Hassouna ◽  
O. Nishizawa ◽  
I. Miyagawa ◽  
A. Toguri ◽  
M. Gotoh ◽  
...  
Keyword(s):  
Calcium Ion ◽  
In Vivo Study ◽  
Detrusor Muscle ◽  
Bladder Detrusor

Precipitation of Microalloy Carbo-Nitrides Prior, during and after γ/α Transformation

2005 ◽  
Vol 500-501 ◽  
pp. 75-86 ◽  
Author(s):  
Stanislaw Zajac
Keyword(s):  
Grain Refinement ◽  
Acicular Ferrite ◽  
Driving Force ◽  
Polygonal Ferrite ◽  
Precipitation Strengthening ◽  
Strengthening Mechanisms ◽  
Thermodynamics And Kinetics ◽  
Bainitic Steels ◽  
Kinetics Of

A brief summary is given of the desired effects of precipitation of microalloy nitrides and carbides in austenite and ferrite prior, during and after g−a transformation. Precipitation of microalloy compounds of Nb(C,N), TiC and V(C,N) is discussed in relation to several grain refinement and precipitation strengthening mechanisms. An improved understanding of the thermodynamics and kinetics of precipitation and phase transformations is presented using the approach based on the chemical driving force. Nucleation of intragranular polygonal ferrite on VN particles that grow in austenite and the formation of acicular ferrite inside the austenitic grains in Vsteels is described. The role of carbon in increasing the driving force for nucleation is elucidated and the benefits of using microalloy carbo-nitrides for precipitation strengthening of bainitic steels are reviewed. An expanded view on the role of microalloy carbo-nitrides in grain refinement and precipitation strengthening is presented.

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