Crystal Engineering of Isostructural Quaternary Multicomponent Crystal Forms of Olanzapine

2012 ◽  
Vol 12 (8) ◽  
pp. 4194-4201 ◽  
Author(s):  
Heather D. Clarke ◽  
Magali B. Hickey ◽  
Brian Moulton ◽  
Jason A. Perman ◽  
Matthew L. Peterson ◽  
...  
Keyword(s):  
Crystal Engineering ◽  
Crystal Forms

scholarly journals Crystal engineering of multicomponent crystal forms of antituberculosis drugs

2017 ◽  
Vol 73 (a2) ◽  
pp. C207-C207
Author(s):  
Javier Ellena ◽  
Luan Farinelli Diniz ◽  
Cristiane Cabral de Melo ◽  
Paulo de Sousa Carvalho Jr
Keyword(s):  
Crystal Engineering ◽  
Antituberculosis Drugs ◽  
Crystal Forms

Crystal Engineering of Multicomponent Crystal Forms of p-Aminosalicylic Acid with Pyridine Based Coformers

2016 ◽  
Vol 16 (3) ◽  
pp. 1268-1281 ◽  
Author(s):  
Pramod Kumar Goswami ◽  
Ram Thaimattam ◽  
Arunachalam Ramanan
Keyword(s):  
Crystal Engineering ◽  
Aminosalicylic Acid ◽  
Crystal Forms

scholarly journals Mechanochemistry in Portugal—A Step towards Sustainable Chemical Synthesis

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 241
Author(s):  
Vânia André ◽  
M. Teresa Duarte ◽  
Clara S. B. Gomes ◽  
Mafalda C. Sarraguça
Keyword(s):  
Crystal Engineering ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Inorganic Synthesis ◽  
Crystal Forms ◽  
Crystalline Materials ◽  
Pharmaceutical Ingredients ◽  
Research Areas ◽  
Metal Organic ◽  
Synthesized Materials

In Portugal, publications with mechanochemical methods date back to 2009, with the report on mechanochemical strategies for the synthesis of metallopharmaceuticals. Since then, mechanochemical applications have grown in Portugal, spanning several fields, mainly crystal engineering and supramolecular chemistry, catalysis, and organic and inorganic chemistry. The area with the most increased development is the synthesis of multicomponent crystal forms, with several groups synthesizing solvates, salts, and cocrystals in which the main objective was to improve physical properties of the active pharmaceutical ingredients. Recently, non-crystalline materials, such as ionic liquids and amorphous solid dispersions, have also been studied using mechanochemical methods. An area that is in expansion is the use of mechanochemical synthesis of bioinspired metal-organic frameworks with an emphasis in antibiotic coordination frameworks. The use of mechanochemistry for catalysis and organic and inorganic synthesis has also grown due to the synthetic advantages, ease of synthesis, scalability, sustainability, and, in the majority of cases, the superior properties of the synthesized materials. It can be easily concluded that mechanochemistry is expanding in Portugal in diverse research areas.

Crystal Forms of Enzalutamide and a Crystal Engineering Route to Drug Purification

2018 ◽  
Vol 18 (7) ◽  
pp. 3774-3780 ◽  
Author(s):  
Lucia Maini ◽  
Dario Braga ◽  
Francesco Farinella ◽  
Elisa Melotto ◽  
Massimo Verzini ◽  
...  
Keyword(s):  
Crystal Engineering ◽  
Crystal Forms

The low-resolution 3D-structure of porin, a channel-forming protein in E. coliouter membranes

1983 ◽  
Vol 41 ◽  
pp. 440-441
Author(s):  
A. Engel ◽  
D.L. Dorset ◽  
A. Massalski ◽  
J.P. Rosenbusch
Keyword(s):  
Crystal Packing ◽  
3D Structure ◽  
Gram Negative Bacteria ◽  
Protein Ratio ◽  
Crystal Forms ◽  
Large Molecules ◽  
Functional Studies ◽  
Voltage Dependent ◽  
Planar Membranes ◽  
Hexagonal Arrays

Porins represent a group of channel forming proteins that facilitate diffusion of small solutes across the outer membrane of Gram-negative bacteria, while excluding large molecules (>650 Da). Planar membranes reconstituted from purified matrix porin (OmpF protein) trimers and phospholipids have allowed quantitative functional studies of the voltage-dependent channels and revealed concerted activation of triplets. Under the same reconstitution conditions but using high protein concentrations porin aggregated to 2D lattices suitable for electron microscopy and image processing. Depending on the lipid-to- protein ratio three different crystal packing arrangements were observed: a large (a = 93 Å) and a small (a = 79 Å) hexagonal and a rectangular (a = 79 Å b = 139 Å) form with p3 symmetry for the hexagonal arrays. In all crystal forms distinct stain filled triplet indentations could be seen and were found to be morphologically identical within a resolution of (22 Å). It is tempting to correlate stain triplets with triple channels, but the proof of this hypothesis requires an analysis of the structure in 3 dimensions.

Template mediated crystal engineering

1994 ◽  
Vol 52 ◽  
pp. 480-481
Author(s):  
Brigid R. Heywood ◽  
S. Champ
Keyword(s):  
Crystal Engineering ◽  
Electrostatic Interactions ◽  
Alkyl Chain ◽  
Crystallographic Axis ◽  
Two Dimensional ◽  
Engineering Process ◽  
Solution Interface ◽  
Extensive Program ◽  
Geometric Homology ◽  
Long Alkyl Chain

Recent work on the crystallisation of inorganic crystals under compressed monomolecular surfactant films has shown that two dimensional templates can be used to promote the oriented nucleation of solids. When a suitable long alkyl chain surfactant is cast on the crystallisation media a monodispersied population of crystals forms exclusively at the monolayer/solution interface. Each crystal is aligned with a specific crystallographic axis perpendicular to the plane of the monolayer suggesting that nucleation is facilitated by recognition events between the nascent inorganic solid and the organic template.For example, monolayers of the long alkyl chain surfactant, stearic acid will promote the oriented nucleation of the calcium carbonate polymorph, calcite, on the (100) face, whereas compressed monolayers of n-eicosyl sulphate will induce calcite nucleation on the (001) face, (Figure 1 & 2). An extensive program of research has confirmed the general principle that molecular recognition events at the interface (including electrostatic interactions, geometric homology, stereochemical complementarity) can be used to promote the crystal engineering process.

The Simplest Patterns of Interpenetrated Honeycomb Layers – Counter examples to the Minimal Transitivity Principle?

2018 ◽  
Author(s):  
Igor Baburin
Keyword(s):  
Crystal Engineering ◽  
Structural Chemistry ◽  
Broad Context ◽  
Rigorous Derivation ◽  
New Approach

The paper calls attention to the most symmetric interpenetration patterns of honeycomb layers. To the best of my knowledge, such patterns remained unknown so far. In my contribution a rigorous derivation of such patterns is given that makes use of a new approach to interpenetrating nets. The results are presented in a broad context of structural chemistry and crystal engineering.

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