Effect of Long-Term In Vitro Testing on the Properties of Bioactive Glass−Polysulfone Composites

2010 ◽  
Vol 11 (3) ◽  
pp. 657-665 ◽  
Author(s):  
Rodrigo Oréfice ◽  
Jon West ◽  
Guy LaTorre ◽  
Larry Hench ◽  
Anthony Brennan
Keyword(s):  
Bioactive Glass ◽  
In Vitro Testing

The Primary Investigation on Biological Effect of Mesoporous Bioactive Glass In Vivo

2013 ◽  
Vol 750-752 ◽  
pp. 1651-1655
Author(s):  
Bai Yan Sui ◽  
Cheng Tie Wu ◽  
Jiao Sun
Keyword(s):  
Bioactive Glass ◽  
Biological Effect ◽  
Degradation Products ◽  
Long Term Effect ◽  
Liver And Kidney ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass (MBG) has superior bioactivity and degradation than non-mesoporous bioactive glass (BG) in vitro. But the biological effect of MBG in vivo is still unknown. In this study, MBG powders with 20μm were implanted into the femoral condyles in SD rats. BG powders with 20μm were used as a control. The local degradation and osteogenesis were observed at 1 week and 4 weeks after implantation, and the systemic toxicity of the degradation products were also evaluated simultaneously. The results revealed MBG powders had the faster rate of degradation and better osteogenesis effect than BG powders at 4 weeks, although the most of material still remained in situ. Histopathological analyses indicated the degradation products did not have any damage to major organs such as liver and kidney. In conclusion, this preliminary study demonstrated that MBG powders have more excellent biological effect at 4 weeks than that of BG in vivo. However the long-term effect needs to be confirmed.

scholarly journals Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing

2020 ◽  
Vol 8 ◽  
Author(s):  
Joana Mendonça da Silva ◽  
Eloy Erro ◽  
Maooz Awan ◽  
Sherri-Ann Chalmers ◽  
Barry Fuller ◽  
...  
Keyword(s):  
Fluidized Bed ◽  
Small Scale ◽  
In Vitro Testing ◽  
Fluidized Bed Bioreactor ◽  
Dynamic Culture

In Vitro Testing of an Implantable Wireless Telemetry System for Long-Term Electromyography Recordings in Large Animals

2015 ◽  
Vol 39 (10) ◽  
pp. 897-902 ◽  
Author(s):  
Lukas Kneisz ◽  
Ewald Unger ◽  
Hermann Lanmüller ◽  
Winfried Mayr
Keyword(s):  
Telemetry System ◽  
In Vitro Testing ◽  
Wireless Telemetry ◽  
Large Animals

The use of flow cytometric methods in acute and long-term in vitro testing

2005 ◽  
Vol 19 (7) ◽  
pp. 845-852 ◽  
Author(s):  
Helga Tuschl ◽  
Christina E. Schwab
Keyword(s):  
In Vitro Testing ◽  
Flow Cytometric

Vienna 2.2 knee joint simulator for long term in vitro testing

2006 ◽  
Vol 39 ◽  
pp. S50 ◽  
Author(s):  
G. von Skrbensky ◽  
R. Huber
Keyword(s):  
Knee Joint ◽  
In Vitro Testing

Simplified Pulse Reactor for Real-Time Long-Term In Vitro Testing of Biological Heart Valves

2010 ◽  
Vol 38 (5) ◽  
pp. 1919-1927 ◽  
Author(s):  
Martina Schleicher ◽  
Günther Sammler ◽  
Michael Schmauder ◽  
Olaf Fritze ◽  
Agnes J. Huber ◽  
...  
Keyword(s):  
Real Time ◽  
Heart Valves ◽  
In Vitro Testing ◽  
Pulse Reactor

In Vitro Reactivity of Bioactive Glass Fibers

2006 ◽  
Vol 49 ◽  
pp. 246-251 ◽  
Author(s):  
Hanna Arstila ◽  
Mikko Tukiainen ◽  
Leena Hupa ◽  
Heimo O. Ylänen ◽  
Minna Kellomäki ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Glass Fibers ◽  
Time Intervals ◽  
Cross Sectional ◽  
Mechanical Durability ◽  
Stationary Conditions ◽  
Calcium Phosphate Precipitation

Implants with long lasting bioactivity and mechanical sustainability would be of interest in several novel clinical applications. By processing bioactive glass fibers and biodegradable polymers into 3D structures, bone formation ability of glasses and flexibility of polymers can be combined. In order to achieve desired physiological response, reactivity of bioactive glass fibers must be specified. Bundles of fibers within the range of bioactivity were soaked in the simulated body fluid at stationary conditions for several time intervals after which the cross-sectional surfaces of the fibers were studied with SEM-EDXA. The reaction layers and precipitations formed on the fiber surfaces suggest that the fibers react according to three mechanisms depending on the glass composition. Fibers with a high in vitro bioactivity showed the formation of distinct and thick silica –rich and calcium phosphate –rich layers already at one day’s immersion. Fibers of medium bioactivity did not show any clear silica –rich layer but a formation of calcium phosphate precipitations or layers at one day’s immersion. Slow glasses showed sporadic calcium phosphate precipitation only after the longest immersion times. The results indicate that the medium and slow glasses are interesting alternatives for applications where a long term mechanical durability suggested by their slow reactivity in combination with their osteoconductive tendency is desired.

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