Comparative micro-Raman study on standard, cross-linked and vitamin E-blended polyethylene acetabular cups after long-term in vitro testing and ageing

2017 ◽  
Vol 48 (8) ◽  
pp. 1065-1074 ◽  
Author(s):  
Paola Taddei ◽  
Eleonora Pavoni ◽  
Saverio Affatato
Keyword(s):  
Vitamin E ◽  
In Vitro Testing ◽  
Raman Study

scholarly journals Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing

2020 ◽  
Vol 8 ◽  
Author(s):  
Joana Mendonça da Silva ◽  
Eloy Erro ◽  
Maooz Awan ◽  
Sherri-Ann Chalmers ◽  
Barry Fuller ◽  
...  
Keyword(s):  
Fluidized Bed ◽  
Small Scale ◽  
In Vitro Testing ◽  
Fluidized Bed Bioreactor ◽  
Dynamic Culture

Effect of Long-Term In Vitro Testing on the Properties of Bioactive Glass−Polysulfone Composites

2010 ◽  
Vol 11 (3) ◽  
pp. 657-665 ◽  
Author(s):  
Rodrigo Oréfice ◽  
Jon West ◽  
Guy LaTorre ◽  
Larry Hench ◽  
Anthony Brennan
Keyword(s):  
Bioactive Glass ◽  
In Vitro Testing

scholarly journals Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55–70 years:the Zenith Study

2006 ◽  
Vol 95 (6) ◽  
pp. 1134-1142 ◽  
Author(s):  
Christine Feillet-Coudray ◽  
Nathalie Meunier ◽  
Dominique Bayle ◽  
Marion Brandolini-Bunlon ◽  
Maud Andriollo-Sanchez ◽  
...  
Keyword(s):  
Vitamin E ◽  
Healthy Subjects ◽  
Antioxidant Properties ◽  
Ldl Oxidation ◽  
Controlled Study ◽  
Dietary Intakes ◽  
Conjugated Diene ◽  
Double Blind

Zn has been shown to possess antioxidant properties in vitro and in vitro. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women.Three groups of sixteen healthy subjects aged 55–70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E statuswere also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55–70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.

scholarly journals Role of Vitamin E and the Orexin System in Neuroprotection

2021 ◽  
Vol 11 (8) ◽  
pp. 1098
Author(s):  
Maria Ester La Torre ◽  
Ines Villano ◽  
Marcellino Monda ◽  
Antonietta Messina ◽  
Giuseppe Cibelli ◽  
...  
Keyword(s):  
Vitamin E ◽  
Neurodegenerative Diseases ◽  
Antioxidant Properties ◽  
Phenotypic Change ◽  
The Central Nervous System ◽  
Specific Receptors

Microglia are the first line of defense at the level of the central nervous system (CNS). Phenotypic change in microglia can be regulated by various factors, including the orexin system. Neuroinflammation is an inflammatory process mediated by cytokines, by the lack of interaction of specific receptors such as the OX2-OX2R complex, caused by systemic tissue damage or, more often, associated with direct damage to the CNS. Chronic activation of microglia could lead to long-term neurodegenerative diseases. This review aims to explore how tocopherol (vitamin E) and the orexin system may play a role in the prevention and treatment of microglia inflammation and, consequently, in neurodegenerative diseases thanks to its antioxidant properties. The results of animal and in vitro studies provide evidence to support the use of tocopherol for a reduction in microglia inflammation as well as a greater activation of the orexinergic system. Although there is much in vivo and in vitro evidence of vitamin E antioxidant and protective abilities, there are still conflicting results for its use as a treatment for neurodegenerative diseases that speculate that vitamin E, under certain conditions or genetic predispositions, can be pro-oxidant and harmful.

In Vitro Testing of an Implantable Wireless Telemetry System for Long-Term Electromyography Recordings in Large Animals

2015 ◽  
Vol 39 (10) ◽  
pp. 897-902 ◽  
Author(s):  
Lukas Kneisz ◽  
Ewald Unger ◽  
Hermann Lanmüller ◽  
Winfried Mayr
Keyword(s):  
Telemetry System ◽  
In Vitro Testing ◽  
Wireless Telemetry ◽  
Large Animals

The use of flow cytometric methods in acute and long-term in vitro testing

2005 ◽  
Vol 19 (7) ◽  
pp. 845-852 ◽  
Author(s):  
Helga Tuschl ◽  
Christina E. Schwab
Keyword(s):  
In Vitro Testing ◽  
Flow Cytometric

Vienna 2.2 knee joint simulator for long term in vitro testing

2006 ◽  
Vol 39 ◽  
pp. S50 ◽  
Author(s):  
G. von Skrbensky ◽  
R. Huber
Keyword(s):  
Knee Joint ◽  
In Vitro Testing

Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken

Reproduction ◽  
2000 ◽  
pp. 257-264 ◽  
Author(s):  
PF Surai ◽  
RC Noble ◽  
NH Sparks ◽  
BK Speake
Keyword(s):  
Vitamin E ◽  
Age Related ◽  
Sperm Output ◽  
Docosatetraenoic Acid ◽  
Testis Mass ◽  
Docosahexaenoic Acids ◽  
Maize Oil ◽  
Vitamin E Supplementation

The possibility was investigated that dietary supplementation of the male chicken with long-chain polyunsaturated fatty acids of the n-6 and n-3 series may prevent the decrease in sperm output that normally occurs by 60 weeks of age. From 26 weeks of age, birds were raised on wheat-based diets supplemented with either maize oil (rich in linoleic acid, 18:2n-6), arasco oil (rich in arachidonic acid, 20:4n-6) or tuna orbital oil (rich in docosahexaenoic acid, 22:6n-3). The effects of the last two oils were investigated at two levels of vitamin E supplementation (40 and 200 mg kg(-1) feed). By 60 weeks of age, there was a small increase in the proportion of the main polyunsaturate of chicken sperm phospholipid, docosatetraenoic acid 22:4n-6, in chickens fed arasco oil diet compared with chickens given the maize oil diet, an effect that was potentiated at the higher dietary intake of vitamin E. Supplementation with tuna orbital oil significantly reduced the proportions of 20:4n-6 and 22:4n-6 in the sperm phospholipid and increased the proportion of 22:6n-3. The diet supplemented with tuna orbital oil and the lower level of vitamin E markedly depleted vitamin E from the tissues of the birds and decreased the concentration of vitamin E in the semen; these effects were largely prevented by the higher level of vitamin E in the diet. The susceptibility of semen to lipid peroxidation in vitro was increased in chickens fed arasco and tuna orbital oils with 40 mg vitamin E kg(-1) feed, but was reduced when 200 mg vitamin E kg(-1) feed was provided in the diet. The number of spermatozoa per ejaculate decreased by 50% between 26 weeks and 60 weeks of age in the birds fed the maize oil diet. This age-related decrease in the number of spermatozoa was almost completely prevented by feeding the birds with the oils enriched in either 20:4n-6 or 22:6n-3. Testis mass at 60 weeks of age was approximately 1.5 times greater in birds given of the arasco and tuna orbital oil diets compared with those given the maize oil diet.

Simplified Pulse Reactor for Real-Time Long-Term In Vitro Testing of Biological Heart Valves

2010 ◽  
Vol 38 (5) ◽  
pp. 1919-1927 ◽  
Author(s):  
Martina Schleicher ◽  
Günther Sammler ◽  
Michael Schmauder ◽  
Olaf Fritze ◽  
Agnes J. Huber ◽  
...  
Keyword(s):  
Real Time ◽  
Heart Valves ◽  
In Vitro Testing ◽  
Pulse Reactor

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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