In Vivo Degradation and Tissue Response to Poly(5-ethylene ketal ε-caprolactone-co-d,l-lactide)

2012 ◽  
Vol 13 (7) ◽  
pp. 2211-2217 ◽  
Author(s):  
Iyabo Oladunni Babasola ◽  
Juares Bianco ◽  
Brian G. Amsden
Keyword(s):  
Tissue Response ◽  
In Vivo Degradation

In vivo degradation of magnesium plate/screw osteosynthesis implant systems: Soft and hard tissue response in a calvarial model in miniature pigs

2016 ◽  
Vol 44 (3) ◽  
pp. 309-317 ◽  
Author(s):  
Benoit Schaller ◽  
Nikola Saulacic ◽  
Thomas Imwinkelried ◽  
Stefan Beck ◽  
Edwin Wei Yang Liu ◽  
...  
Keyword(s):  
Tissue Response ◽  
Hard Tissue ◽  
Screw Osteosynthesis ◽  
Miniature Pigs ◽  
In Vivo Degradation

Study of biodegradation and biocompatibility of PEGylated rosin derivatives

2017 ◽  
Vol 32 (6) ◽  
pp. 628-640 ◽  
Author(s):  
Dinesh M Morkhade ◽  
Vishwanath S Nande ◽  
Umesh V Barabde ◽  
Siddheshwar B Joshi
Keyword(s):  
Molecular Weight ◽  
Weight Loss ◽  
Polyethylene Glycol ◽  
Inflammatory Responses ◽  
Tissue Response ◽  
Polyethylene Glycol 400 ◽  
Constant Weight ◽  
In Vivo Degradation

PEGylated rosin derivatives are improved in series ester-adduct derivatives of rosin. The aim of this study was to assess biodegradation and biocompatibility of PEGylated rosin derivatives. Study employed two different PEGylated rosin derivatives, namely, D1 and D2, with constant weight of rosin and increasing amounts of polyethylene glycol 400. PEGylated rosin derivatives were synthesized and tailored into spherical beads and disks with smooth surface for use. In vitro degradation was studied at pH 4.0, 7.4, and 10 for 60 days. In vivo study was performed in Wistar rats using poly(d,l-lactide- co-glycolide) (50:50) as a control. Post 3, 7, 14, and 21 days of implantation, PEGylated rosin derivatives disks were retrieved and evaluated for weight loss, molecular weight decline, morphology, and tissue response. D1 and D2 beads showed 21.68% and 32.37% weight loss, respectively, at pH 7.4 post 60 days. Degradation was increased substantially with increase in pH of medium. Degradation of disks was markedly slower than that of beads. In vivo degradation of PEGylated rosin derivative disks was faster than in vitro. Post 60 days of implantation, weight loss of D1 and D2 disk was 7.57% and 11.84%, whereas molecular weight was declined by about 19% and 26%, respectively. Owing to higher amounts of polyethylene glycol 400, in vitro and in vivo degradation of D2 was faster than D1. Poly(d,l-lactide- co-glycolide) as well as PEGylated rosin derivative implants evoked mild inflammatory responses characterized by few macrophages and absence of exudation at tissue–disk interface. The cellular density in tissue surrounding PEGylated rosin derivative disks increased initially with time up to 7 days and decreased eventually at the end of 21 days. The trend was similar for poly(d,l-lactide- co-glycolide) implants. Increase in polyethylene glycol 400 improved biodegradation and biocompatibility of PEGylated rosin derivatives. Results revealed that PEGylated rosin derivatives degrade slowly in vivo over a period of time, possess fair biocompatibility, and thus are promising biomaterial for drug delivery applications.

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

scholarly journals In-Vivo Degradation Behavior and Osseointegration of 3D Powder-Printed Calcium Magnesium Phosphate Cement Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 946
Author(s):  
Katharina Kowalewicz ◽  
Elke Vorndran ◽  
Franziska Feichtner ◽  
Anja-Christina Waselau ◽  
Manuel Brueckner ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bone Substitutes ◽  
Magnesium Phosphate ◽  
Degradation Behavior ◽  
Micro Computed Tomography ◽  
Calcium Magnesium ◽  
Interest In Research ◽  
In Vivo Degradation ◽  
Volume Decrease

Calcium magnesium phosphate cements (CMPCs) are promising bone substitutes and experience great interest in research. Therefore, in-vivo degradation behavior, osseointegration and biocompatibility of three-dimensional (3D) powder-printed CMPC scaffolds were investigated in the present study. The materials Mg225 (Ca0.75Mg2.25(PO4)2) and Mg225d (Mg225 treated with diammonium hydrogen phosphate (DAHP)) were implanted as cylindrical scaffolds (h = 5 mm, Ø = 3.8 mm) in both lateral femoral condyles in rabbits and compared with tricalcium phosphate (TCP). Treatment with DAHP results in the precipitation of struvite, thus reducing pore size and overall porosity and increasing pressure stability. Over 6 weeks, the scaffolds were evaluated clinically, radiologically, with Micro-Computed Tomography (µCT) and histological examinations. All scaffolds showed excellent biocompatibility. X-ray and in-vivo µCT examinations showed a volume decrease and increasing osseointegration over time. Structure loss and volume decrease were most evident in Mg225. Histologically, all scaffolds degraded centripetally and were completely traversed by new bone, in which the remaining scaffold material was embedded. While after 6 weeks, Mg225d and TCP were still visible as a network, only individual particles of Mg225 were present. Based on these results, Mg225 and Mg225d appear to be promising bone substitutes for various loading situations that should be investigated further.

In vitro and in vivo degradation of silk fibers degummed with various sodium carbonate concentrations

2021 ◽  
Vol 27 ◽  
pp. 102369
Author(s):  
Shijun Lu ◽  
Xiaochen Tang ◽  
Qingqing Lu ◽  
Jiwei Huang ◽  
Xinran You ◽  
...  
Keyword(s):  
Sodium Carbonate ◽  
Silk Fibers ◽  
In Vivo Degradation

In vivo behavior of trimethylene carbonate and ε-caprolactone-based (co)polymer networks: Degradation and tissue response

2010 ◽  
Vol 95A (3) ◽  
pp. 940-949 ◽  
Author(s):  
Erhan Bat ◽  
Josée A. Plantinga ◽  
Martin C. Harmsen ◽  
Marja J. A. van Luyn ◽  
Jan Feijen ◽  
...  
Keyword(s):  
Polymer Networks ◽  
Tissue Response ◽  
Trimethylene Carbonate

scholarly journals Improvement of biohistological response of facial implant materials by tantalum surface treatment

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Mohammed Mousa Bakri ◽  
Sung Ho Lee ◽  
Jong Ho Lee
Keyword(s):  
Foreign Body ◽  
Soft Tissue ◽  
Surface Treatment ◽  
Clinical Applications ◽  
Tissue Response ◽  
Bone Surface ◽  
Tissue Thickness ◽  
Implant Materials ◽  
Soft Tissue Thickness

Abstract Background A compact passive oxide layer can grow on tantalum (Ta). It has been reported that this oxide layer can facilitate bone ingrowth in vivo though the development of bone-like apatite, which promotes hard and soft tissue adhesion. Thus, Ta surface treatment on facial implant materials may improve the tissue response, which could result in less fibrotic encapsulation and make the implant more stable on the bone surface. The purposes of this study were to verify whether surface treatment of facial implant materials using Ta can improve the biohistobiological response and to determine the possibility of potential clinical applications. Methods Two different and commonly used implant materials, silicone and expanded polytetrafluoroethylene (ePTFE), were treated via Ta ion implantation using a Ta sputtering gun. Ta-treated samples were compared with untreated samples using in vitro and in vivo evaluations. Osteoblast (MG-63) and fibroblast (NIH3T3) cell viability with the Ta-treated implant material was assessed, and the tissue response was observed by placing the implants over the rat calvarium (n = 48) for two different lengths of time. Foreign body and inflammatory reactions were observed, and soft tissue thickness between the calvarium and the implant as well as the bone response was measured. Results The treatment of facial implant materials using Ta showed a tendency toward increased fibroblast and osteoblast viability, although this result was not statistically significant. During the in vivo study, both Ta-treated and untreated implants showed similar foreign body reactions. However, the Ta-treated implant materials (silicone and ePTFE) showed a tendency toward better histological features: lower soft tissue thickness between the implant and the underlying calvarium as well as an increase in new bone activity. Conclusion Ta surface treatment using ion implantation on silicone and ePTFE facial implant materials showed the possibility of reducing soft tissue intervention between the calvarium and the implant to make the implant more stable on the bone surface. Although no statistically significant improvement was observed, Ta treatment revealed a tendency toward an improved biohistological response of silicone and ePTFE facial implants. Conclusively, tantalum treatment is beneficial and has the potential for clinical applications.

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